Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.

abstract：:A hemoglobin-supplemented medium composed of Columbia agar base supplemented with 1% hemoglobin and 1% Polyvitex was used to investigate the in vitro activity of 29 antimicrobial agents against Capnocytophaga species. Clindamycin was the most active agent, with all strains being inhibited by 0.06 microgram/ml or less....

journal_title：Antimicrobial agents and chemotherapy

authors： Rummens JL,Gordts B,Van Landuyt HW

更新日期：1986-11-01 00:00:00

abstract：:Community-acquired multidrug resistant Enterobacteriaceae (MDR-Ent) infections continue to increase in the United States. In prior studies, we identified neighboring regions in Chicago, Illinois, where children have 5 to 6 times greater odds of MDR-Ent infections. To prevent community spread of MDR-Ent, we need to ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Logan LK,Zhang L,Green SJ,Dorevitch S,Arango-Argoty GA,Reme K,Garner E,Aldstadt J,Johnson-Walker YJ,Hayden MK,Weinstein RA,Pruden A

更新日期：2020-03-24 00:00:00

abstract：:Staphylococcus epidermidis is a major cause of nosocomial infections because of its ability to form biofilms on the surface of medical devices. Only a few antibacterial agents are relatively active against biofilms, and rifampin, a transcription inhibitor, ranks among the most effective molecules against biofilm-relat...

journal_title：Antimicrobial agents and chemotherapy

authors： Villain-Guillot P,Gualtieri M,Bastide L,Leonetti JP

更新日期：2007-09-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1,10-phenanthrolene, but not endoproteinase inhibitors, blocked enzymatic...

journal_title：Antimicrobial agents and chemotherapy

authors： Okhuysen PC,Chappell CL,Kettner C,Sterling CR

更新日期：1996-12-01 00:00:00

abstract：:A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

journal_title：Antimicrobial agents and chemotherapy

authors： Alonso A,Sanchez P,Martínez JL

更新日期：2000-07-01 00:00:00

abstract：:GS-9148 is an investigational phosphonate nucleotide analogue inhibitor of reverse transcriptase (RT) (NtRTI) of human immunodeficiency virus type 1 (HIV-1). This compound is an adenosine derivative with a 2',3'-dihydrofuran ring structure that contains a 2'-fluoro group. The resistance profile of GS-9148 is unique in...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarth BJ,White KL,Chen JM,Lansdon EB,Swaminathan S,Miller MD,Götte M

更新日期：2011-06-01 00:00:00

abstract：:We have previously shown that genetic disruption of Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3) affects calcium ionophore-induced egress. We examined whether Plasmodium falciparum CDPK1 (PfCDPK1), the closest homolog of TgCDPK3 in the malaria parasite P. falciparum, could complement a TgCDPK3 mutant...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaji RY,Checkley L,Reese ML,Ferdig MT,Arrizabalaga G

更新日期：2014-05-01 00:00:00

abstract：:A novel staphylococcal cassette chromosome mec (SCCmec) composite island (SCCmecAI16-SCCczrAI16-CI) was identified in Staphylococcus pseudintermedius. Four integration site sequences for SCC subdivided the 60,734-bp island into 41,232-bp SCCmecAI16, 19,400-bp SCCczrAI16, and 102-bp SCC-likeAI16 elements. SCCmecAI16 re...

journal_title：Antimicrobial agents and chemotherapy

authors： Chanchaithong P,Prapasarakul N,Perreten V,Schwendener S

更新日期：2015-12-07 00:00:00

abstract：:Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions, such as thrombocytopenia, when standard-dose linezolid is used than patients with LD who did not use linezolid. Curre...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang SH,Zhu ZY,Chen Z,Li Y,Zou Y,Yan M,Xu Y,Wang F,Liu MZ,Zhang M,Zhang BK

更新日期：2020-05-21 00:00:00

abstract：:The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen YT,Liao TL,Liu YM,Lauderdale TL,Yan JJ,Tsai SF

更新日期：2009-03-01 00:00:00

abstract：:Delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of Gram-positive and Gram-negative bacteria. In this study, 200 Streptococcus pneumoniae (plus 30 levofloxacin-resistant isolates), 200 Haemophilus influenzae, and 100 Moraxella catarrhalis isolates selected primarily from the Un...

journal_title：Antimicrobial agents and chemotherapy

authors： Flamm RK,Rhomberg PR,Huband MD,Farrell DJ

更新日期：2016-09-23 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:The incidence of triazole-resistant Aspergillus infections is increasing worldwide, often mediated through mutations in the CYP51A amino acid sequence. New classes of azole-based drugs are required to combat the increasing resistance to existing triazole therapeutics. In this study, a CYP51 reconstitution assay is des...

journal_title：Antimicrobial agents and chemotherapy

authors： Warrilow AG,Parker JE,Price CL,Nes WD,Kelly SL,Kelly DE

更新日期：2015-12-01 00:00:00

abstract：:Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

更新日期：2020-10-20 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a range of medically significant pathogens. Previous work using Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Djoko KY,Goytia MM,Donnelly PS,Schembri MA,Shafer WM,McEwan AG

更新日期：2015-10-01 00:00:00

abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

更新日期：2013-01-01 00:00:00

abstract：:Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Wold JS,Turnipseed SA,Broddle WD,Owen NV

更新日期：1977-10-01 00:00:00

abstract：:The anti-pseudomonas activities of azlocillin and mezlocillin were compared with that of ticarcillin. We measured the minimal inhibitory and minimal bactericidal concentrations of the three drugs against 20 different strains of Pseudomonas aeruginosa and found significantly lower values for azlocillin than for the oth...

journal_title：Antimicrobial agents and chemotherapy

authors： Coppens L,Klastersky J

更新日期：1979-03-01 00:00:00

abstract：:The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytope...

journal_title：Antimicrobial agents and chemotherapy

authors： Calame W,van der Waals R,Mattie H,van Furth R

更新日期：1989-06-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:The human fungal pathogen Candida albicans develops drug resistance after long-term exposure to azole drugs in the treatment of chronic candidiasis. Gain-of-function (GOF) mutations in the transcription factor Tac1 and the consequent expression of its targets, drug efflux pumps Cdr1 and Cdr2, are a common mechanism by...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu Z,Myers LC

更新日期：2017-10-24 00:00:00

abstract：:A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously on...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzariol A,Roelofsen E,Koncan R,Voss A,Cornaglia G

更新日期：2007-03-01 00:00:00

abstract：:Resistance of Plasmodium falciparum to drugs such as chloroquine and sulfadoxine-pyrimethamine is a major problem in malaria control. Artemisinin (ART) derivatives, particularly in combination with other drugs, are thus increasingly used to treat malaria, reducing the probability that parasites resistant to the compon...

journal_title：Antimicrobial agents and chemotherapy

authors： Afonso A,Hunt P,Cheesman S,Alves AC,Cunha CV,do Rosário V,Cravo P

更新日期：2006-02-01 00:00:00

abstract：:This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin treatment. Blood samples were analyzed using a validated liquid chromatography-tandem mass spectrometry tec...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker SL,Frantzeskaki F,Wallis SC,Diakaki C,Giamarellou H,Koulenti D,Karaiskos I,Lipman J,Dimopoulos G,Roberts JA

更新日期：2015-10-01 00:00:00

abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

更新日期：1998-03-01 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00

abstract：:The in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (Corynebacterium group JK). The activities of vancomycin and teicoplanin were similar (MIC for 90% of strains tested [MIC90], 1 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Spitzer PG,Eliopoulos GM,Karchmer AW,Moellering RC Jr

更新日期：1988-04-01 00:00:00