Placental transfer of darunavir in an ex vivo human cotyledon perfusion model.

Abstract:

:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40.3%±5.8%. This shows that darunavir crosses the placenta at a relatively low rate, resulting in fetal exposure.

authors

Mandelbrot L,Duro D,Belissa E,Peytavin G

doi

10.1128/AAC.03184-14

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

5617-20

issue

9

eissn

0066-4804

issn

1098-6596

pii

AAC.03184-14

journal_volume

58

pub_type

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