当前位置： SCI文献检索 > ANTIMICROBIAL AGENTS AND CHEMOTHERAPY期刊下所有文献 > Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia.

Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia.

Abstract：

:In addition to cholesterol-lowering capabilities, statins possess anti-inflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized patients with positive S. aureus blood cultures receiving appropriate antibiotics within 48 h of culture collection (Veterans Affairs hospitals, 2002 to 2013). Three statin exposure groups were compared to nonusers: pretreated statin users initiating therapy in the 30 days prior to culture and either (i) continuing statin therapy after culture or (ii) not continuing after culture, and (iii) de novo users initiating at culture. Nonusers included patients without statins in the year prior to culture through discharge. Propensity score-matched Cox proportional hazards regression models were developed. We were able to balance significantly different baseline characteristics using propensity score matching for pretreated without continuation (n = 331), pretreated with continuation (n = 141), and de novo (n = 177) statin users compared to nonusers. We observed a significantly lower 30-day mortality rate (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.25 to 0.84; number needed to treat [NNT], 10) among pretreated and continued statin users, while protective effects were not observed in de novo (HR, 1.04; 95% CI, 0.60 to 1.82; NNT, undefined) or pretreated but not continued (HR, 0.92; 95% CI, 0.64 to 1.32; NNT, 47) users. In our national cohort study among patients with S. aureus bacteremia, continuation of statin therapy among incident statin users was associated with significant beneficial effects on mortality, including a 54% lower 30-day mortality rate.

journal_name

Antimicrob Agents Chemother

journal_title

Antimicrobial agents and chemotherapy

authors

Caffrey AR,Timbrook TT,Noh E,Sakoulas G,Opal SM,Nizet V,LaPlante KL

doi

10.1128/AAC.02228-16

subject

Has Abstract

pub_date

2017-02-23 00:00:00

issue

3

eissn

0066-4804

issn

1098-6596

pii

AAC.02228-16

journal_volume

61

pub_type

杂志文章

相关文献

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY文献大全
  • Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

    abstract：:In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00996-10

    authors： Swick MC,Morgan-Linnell SK,Carlson KM,Zechiedrich L

    更新日期：2011-02-01 00:00:00

  • Changing antimicrobial resistance profiles among Neisseria gonorrhoeae isolates in Italy, 2003 to 2012.

    abstract：:The emergence of Neisseria gonorrhoeae isolates displaying resistance to antimicrobial agents is a major public health concern and a serious issue related to the occurrence of further untreatable gonorrhea infections. A retrospective analysis on 1,430 N. gonorrhoeae isolates, collected from 2003 through 2012, for anti...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00103-14

    authors： Carannante A,Renna G,Dal Conte I,Ghisetti V,Matteelli A,Prignano G,Impara G,Cusini M,D'Antuono A,Vocale C,Antonetti R,Gaino M,Busetti M,Latino MA,Mencacci A,Bonanno C,Cava MC,Giraldi C,Stefanelli P

    更新日期：2014-10-01 00:00:00

  • Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.

    abstract：:Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial did not show that Carraguard is effective in ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.05461-11

    authors： Fernández-Romero JA,Abraham CJ,Rodriguez A,Kizima L,Jean-Pierre N,Menon R,Begay O,Seidor S,Ford BE,Gil PI,Peters J,Katz D,Robbiani M,Zydowsky TM

    更新日期：2012-01-01 00:00:00

  • In vitro susceptibility testing procedures for fosfomycin tromethamine.

    abstract：:Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.35.6.1235

    authors： Barry AL,Fuchs PC

    更新日期：1991-06-01 00:00:00

  • Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae.

    abstract：:We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. Monte Carlo simulations were used to define the permissible HDCI meropenem regimens that could be saf...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00794-17

    authors： Cojutti P,Sartor A,Righi E,Scarparo C,Bassetti M,Pea F

    更新日期：2017-09-22 00:00:00

  • Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.

    abstract：:L-nucleoside analogs are a new class of antiviral and anticancer agents, several of which are currently used in the clinic. The phosphorylation of these agents to the triphosphate form is thought to be important for exertion of their pharmacological activities. 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylur...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.49.5.2044-2049.2005

    authors： Hu R,Li L,Degrève B,Dutschman GE,Lam W,Cheng YC

    更新日期：2005-05-01 00:00:00

  • Many class I integrons comprise distinct stable structures occurring in different species of Enterobacteriaceae isolated from widespread geographic regions in Europe.

    abstract：:Three sizes of inserted regions of DNA (800, 1,000, and 1,500 bp) were shown to be common among class I integrons in unrelated clinical isolates of Enterobacteriaceae from different European hospitals. Sequencing showed that 800-bp inserted regions comprised identical sequences including aacA4, that 1,000-bp inserted ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.43.3.686

    authors： Martinez-Freijo P,Fluit AC,Schmitz FJ,Verhoef J,Jones ME

    更新日期：1999-03-01 00:00:00

  • Assessment of the Potential for Inducing Resistance in Multidrug-Resistant Organisms from Exposure to Minocycline, Rifampin, and Chlorhexidine Used To Treat Intravascular Devices.

    abstract：:To assess the potential for the induction of antimicrobial resistance following repeated subinhibitory exposures to the combination minocycline (MIN), rifampin (RIF), and chlorhexidine (CHX), a total of 29 clinical microbial pathogenic isolates were repeatedly exposed to subinhibitory concentrations of MIN, RIF, and C...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00040-19

    authors： Rosenblatt J,Vargas-Cruz N,Reitzel RA,Raad II

    更新日期：2019-04-25 00:00:00

  • Comparison of the clinical characteristics and outcomes associated with vancomycin-resistant Enterococcus faecalis and vancomycin-resistant E. faecium bacteremia.

    abstract：:In published studies, cohorts of patients with bacteremia due to vancomycin-resistant Enterococcus (VRE) have predominantly been infected with Enterococcus faecium. Little is known about the epidemiology and outcomes associated with bacteremia due to VR Enterococcus faecalis. A retrospective study of isolates obtained...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.06299-11

    authors： Hayakawa K,Marchaim D,Martin ET,Tiwari N,Yousuf A,Sunkara B,Pulluru H,Kotra H,Hasan A,Bheemreddy S,Sheth P,Lee DW,Kamatam S,Bathina P,Nanjireddy P,Chalana IK,Patel S,Kumar S,Vahia A,Ku K,Yee V,Swan J,Pogue JM

    更新日期：2012-05-01 00:00:00

  • Dosing regimen matters: the importance of early intervention and rapid attainment of the pharmacokinetic/pharmacodynamic target.

    abstract：:To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to intermittent subopt...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章,评审

    doi：10.1128/AAC.05360-11

    authors： Martinez MN,Papich MG,Drusano GL

    更新日期：2012-06-01 00:00:00

  • Correlation of β-Lactamase Production and Colistin Resistance among Enterobacteriaceae Isolates from a Global Surveillance Program.

    abstract：:The increasing use of carbapenems for treating multidrug-resistant (MDR) Gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Serine and metallo-β-lactamases (MBLs) that hydrolyze carbapenems have become prevalent and endemic in some countries...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01870-15

    authors： Bradford PA,Kazmierczak KM,Biedenbach DJ,Wise MG,Hackel M,Sahm DF

    更新日期：2015-12-14 00:00:00

  • Longitudinal use of a line probe assay for human immunodeficiency virus type 1 protease predicts phenotypic resistance and clinical progression in patients failing highly active antiretroviral therapy.

    abstract：:An observational study assessed the longitudinal use of a new line probe assay for the detection of protease mutations. Probe assays for detection of reverse transcriptase (Inno-LiPA HIV-1 RT; Innogenetics) and protease (prototype kit Inno-LiPA HIV Protease; Innogenetics) mutations gave results for 177 of 199 sequenti...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.46.6.1928-1933.2002

    authors： Servais J,Lambert C,Plesséria JM,Fontaine E,Robert I,Arendt V,Staub T,Hemmer R,Schneider F,Schmit JC

    更新日期：2002-06-01 00:00:00

  • No findings of dental defects in children treated with minocycline.

    abstract：:Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.48.7.2739-2741.2004

    authors： Cascio A,Di Liberto C,D'Angelo M,Iaria C,Scarlata F,Titone L,Campisi G

    更新日期：2004-07-01 00:00:00

  • Effect of a Salmonella group H1 R factor on virulence and response of infections to antimicrobial therapy.

    abstract：:A group H1 R factor encoding resistance to chloramphenicol, streptomycin, sulfonamide, and tetracycline was transferred into Salmonella typhimurium LT-2. The virulence of LT-2 for mice, as assessed by intraperitoneal 50% lethal dose and the number of organisms in the spleen, was not affected by the R factor. On the ot...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.15.3.478

    authors： Butler T,Shuster CW,Franco A

    更新日期：1979-03-01 00:00:00

  • Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand.

    abstract：:Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between t...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00345-15

    authors： Gaillard T,Sriprawat K,Briolant S,Wangsing C,Wurtz N,Baragatti M,Lavina M,Pascual A,Nosten F,Pradines B

    更新日期：2015-08-01 00:00:00

  • In Vitro activities of combinations of rifampin with other antimicrobials against multidrug-resistant Acinetobacter baumannii.

    abstract：:The antimicrobial treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections has become a great challenge for medical staff all over the world. Increasing numbers of MDR A. baumannii infections have been identified and reported, but effective clinical treatments for them are decreasing. The objective of...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.04089-14

    authors： Bai Y,Liu B,Wang T,Cai Y,Liang B,Wang R,Liu Y,Wang J

    更新日期：2015-03-01 00:00:00

  • 4,4'-isopropylidine-bis(2-isopropyl)phenol, a new inhibitor for cell wall formation of Bacillus subtilis.

    abstract：:4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-g...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.9.4.580

    authors： Shimi IR,Shoukry S,Zaki Z

    更新日期：1976-04-01 00:00:00

  • Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda.

    abstract：:Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-dir...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.48.8.3196-3199.2004

    authors： Krief S,Martin MT,Grellier P,Kasenene J,Sévenet T

    更新日期：2004-08-01 00:00:00

  • Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects.

    abstract：:The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human volunteers. Serum levels of tetracycline were uniformly reduced by approximately 50% by all test meals, whereas serum level...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.11.3.462

    authors： Welling PG,Koch PA,Lau CC,Craig WA

    更新日期：1977-03-01 00:00:00

  • Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei.

    abstract：:Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lo...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00574-07

    authors： Chaturvedi V,Ramani R,Ghannoum MA,Killian SB,Holliday N,Knapp C,Ostrosky-Zeichner L,Messer SA,Pfaller MA,Iqbal NJ,Arthington-Skaggs BA,Vazquez JA,Sein T,Rex JH,Walsh TJ

    更新日期：2008-04-01 00:00:00

  • Kinetics of gentamicin in plasma of nonpregnant, pregnant, and fetal guinea pigs and its distribution in fetal tissues.

    abstract：:Nonpregnant and pregnant guinea pigs in the last third of gestation were injected intramuscularly with 4 mg of gentamicin per kg, and drug concentrations in plasma were determined by radioimmunoassay at several intervals after injection. The maximum gentamicin concentration was lower in pregnant than in nonpregnant an...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.28.4.565

    authors： Lelievre-Pegorier M,Sakly R,Meulemans A,Merlet-Benichou C

    更新日期：1985-10-01 00:00:00

  • Synergy of penicillin and decreasing concentration of aminoglycosides against enterococci from patients with infective endocarditis.

    abstract：:To determine whether low concentrations of aminoglycosides in combination with penicillin could effectively kill enterococci in vitro, we tested penicillin (20 micrograms/ml) in combination with decreasing concentrations of either streptomycin (20, 10, 5, and 1 micrograms/ml) or gentamicin (5, 3, 1, and 0.5 micrograms...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.18.6.944

    authors： Matsumoto JY,Wilson WR,Wright AJ,Geraci JE,Washington JA 2nd

    更新日期：1980-12-01 00:00:00

  • Determination of pyrazinamide MICs for Mycobacterium tuberculosis at different pHs by the radiometric method.

    abstract：:The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between th...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.32.7.1002

    authors： Salfinger M,Heifets LB

    更新日期：1988-07-01 00:00:00

  • In vitro sensitivity of Salmonella to ten antimicrobial agents including sulfamethoxazole and trimethoprim, alone and in combination.

    abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.4.5.555

    authors： Marks MI,Kazemi M,MacKay E

    更新日期：1973-11-01 00:00:00

  • In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria.

    abstract：:The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.44.8.2225-2229.2000

    authors： Boucher HW,Wennersten CB,Eliopoulos GM

    更新日期：2000-08-01 00:00:00

  • Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis.

    abstract：:The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. carinii pneumonitis in 90% or more of rats, while all untreated control a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.34.2.225

    authors： Hughes WT,Gray VL,Gutteridge WE,Latter VS,Pudney M

    更新日期：1990-02-01 00:00:00

  • Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.

    abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00973-06

    authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

    更新日期：2007-04-01 00:00:00

  • Development of rifapentine susceptibility tests for Mycobacterium tuberculosis.

    abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.43.1.25

    authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

    更新日期：1999-01-01 00:00:00

  • Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis.

    abstract：:Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 5...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.11.3.396

    authors： Somma S,Merati W,Parenti F

    更新日期：1977-03-01 00:00:00

  • Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.

    abstract：:The resistome of P. aeruginosa for three β-lactam antibiotics, namely, ceftazidime, imipenem, and meropenem, was deciphered by screening a comprehensive PA14 mutant library for mutants with increased or reduced susceptibility to these antimicrobials. Confirmation of the phenotypes of all selected mutants was performed...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00257-10

    authors： Alvarez-Ortega C,Wiegand I,Olivares J,Hancock RE,Martínez JL

    更新日期：2010-10-01 00:00:00