Susceptibility of Haemophilus influenzae type b to ampicillin-sulbactam.

abstract：:We have developed and validated a high-performance liquid chromatography method coupled with a mass detector to quantify itraconazole, voriconazole, and posaconazole using quinoxaline as the internal standard. The method involves protein precipitation with acetonitrile. Mean accuracy (percent deviation from the true v...

journal_title：Antimicrobial agents and chemotherapy

authors： Baietto L,D'Avolio A,Ventimiglia G,De Rosa FG,Siccardi M,Simiele M,Sciandra M,Di Perri G

更新日期：2010-08-01 00:00:00

abstract：:Mutants of Escherichia coli K-12 that are unable to make use of the enterochelin transport system were used to confirm that streptonigrin requires iron for its bactericidal action. Correlation of viability studies and 55Fe3+ uptake experiments showed that killing by streptonigrin increased with an increase in 55Fe3+ u...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeowell HN,White JR

更新日期：1982-12-01 00:00:00

abstract：:The "HACEK" organisms are a group of fastidious Gram-negative bacteria that cause a variety of infections, including infective endocarditis. Antimicrobial susceptibility testing is not universally available, and therapy for these infections is often empirical. We report the antimicrobial susceptibilities of 70 clinica...

journal_title：Antimicrobial agents and chemotherapy

authors： Coburn B,Toye B,Rawte P,Jamieson FB,Farrell DJ,Patel SN

更新日期：2013-04-01 00:00:00

abstract：:Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams JA,Krizsanovich-Williams K

更新日期：1977-09-01 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. The pharmacokinetic behavior of trimetrexate administered either by intravenous bolus or orally was studied...

journal_title：Antimicrobial agents and chemotherapy

authors： Rogers P,Allegra CJ,Murphy RF,Drake JC,Masur H,Poplack DG,Chabner BA,Parrillo JE,Lane HC,Balis FM

更新日期：1988-03-01 00:00:00

abstract：:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandelbrot L,Duro D,Belissa E,Peytavin G

更新日期：2014-09-01 00:00:00

abstract：:Using an immunocompetent murine model of invasive aspergillosis (IA), we previously reported that the efficacy of liposomal amphotericin B (L-AmB) (Ambisome) is not hampered by the presence of azole resistance mutations in Aspergillus fumigatus (S. Seyedmousavi, W. J. G. Melchers, J. W. Mouton, and P. E. Verweij, Anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Seyedmousavi S,Mouton JW,Melchers WJG,Verweij PE

更新日期：2017-05-24 00:00:00

abstract：:We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-...

journal_title：Antimicrobial agents and chemotherapy

authors： Uckun FM,Chelstrom LM,Tuel-Ahlgren L,Dibirdik I,Irvin JD,Langlie MC,Myers DE

更新日期：1998-02-01 00:00:00

abstract：:Here, we report on the anti-influenza virus activity of the mannose-binding agents, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), and the (N-acetylglucosamine)n-specific Urtica dioica agglutinin (UDA). These carbohydrate-binding agents (CBA) strongly inhibited various influenza A(H1N1), A...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanderlinden E,Van Winkel N,Naesens L,Van Damme EJM,Persoons L,Schols D

更新日期：2020-12-07 00:00:00

abstract：:Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

更新日期：2019-08-23 00:00:00

abstract：:Eight healthy male volunteers received 1 g of either ceftazidime or cefamandole as an intravenous infection. Serial blood samples were taken over the next 8 h. Urine samples were collected over 24 h. Levels of these antibiotics were measured in the fluid of blisters resulting from application of cantharides. The conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Armstrong GC,Wise R,Brown RM,Hancox J

更新日期：1981-09-01 00:00:00

abstract：:Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably les...

journal_title：Antimicrobial agents and chemotherapy

authors： Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

更新日期：1992-01-01 00:00:00

abstract：:In the course of surveying for the carbapenem-hydrolyzing metallo-beta-lactamase gene bla(IMP) in pathogenic bacteria by the PCR method, we detected a gene encoding a variant metallo-beta-lactamase, designated IMP-3, which differed from IMP-1 by having low hydrolyzing activity for penicillins and carbapenems. PCR prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Iyobe S,Kusadokoro H,Ozaki J,Matsumura N,Minami S,Haruta S,Sawai T,O'Hara K

更新日期：2000-08-01 00:00:00

abstract：:Resistance to antifungal drugs, specifically azoles such as fluconazole, in the opportunistic yeast Candida albicans has become an increasing problem in human immunodeficiency virus (HIV)-infected individuals. The molecular mechanisms responsible for this resistance have only recently become apparent and can include a...

journal_title：Antimicrobial agents and chemotherapy

authors： White TC

更新日期：1997-07-01 00:00:00

abstract：:We assessed cutaneous ethanol (ETOH) and isopropanol (ISOP) absorption after intensive (30 times per h) use of alcohol-based hand-rub solutions by healthcare workers (HCWs). ETOH was detectable in the breath of 6/20 HCWs (0.001 to 0.0025%) at 1 to 2 min postexposure and in the serum of 2/20 HCWs at 5 to 7 min postexpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown TL,Gamon S,Tester P,Martin R,Hosking K,Bowkett GC,Gerostamoulos D,Grayson ML

更新日期：2007-03-01 00:00:00

abstract：:Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Reed MD,Stern RC,O'Brien CA,Crenshaw DA,Blumer JL

更新日期：1987-05-01 00:00:00

abstract：:Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs. Conventional modeling of treatment relies on m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodel EM,Kay K,Hastings IM

更新日期：2016-04-22 00:00:00

abstract：:Linezolid was tested against 32 species of uncommonly isolated gram-positive organisms (3,251 strains) by reference MIC methods and found to be highly active (MIC50 range, 0.25 to 2 microg/ml; MIC90 range, 0.25 to 2 microg/ml). Only one isolate (viridans group streptococcus; 0.03% of tested strains) was resistant to l...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Stilwell MG,Hogan PA,Sheehan DJ

更新日期：2007-04-01 00:00:00

abstract：:A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An exce...

journal_title：Antimicrobial agents and chemotherapy

authors： Lichtenwalner DM,Suh B,Lorber B,Sugar AM

更新日期：1979-08-01 00:00:00

abstract：:Pneumocystis carinii synthesizes sterols with a double bond at C-7 of the sterol nucleus and an alkyl group with one or two carbons at C-24 of the side chain. Also, some human-derived Pneumocystis carinii f. sp. hominis strains contain lanosterol derivatives with an alkyl group at C-24. These unique sterols have not b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaneshiro ES,Collins MS,Cushion MT

更新日期：2000-06-01 00:00:00

abstract：:The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pathway is indispensable for Chlamydia growth. Previously, a high-conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Mojica SA,Salin O,Bastidas RJ,Sunduru N,Hedenström M,Andersson CD,Núñez-Otero C,Engström P,Valdivia RH,Elofsson M,Gylfe Å

更新日期：2017-09-22 00:00:00

abstract：:Few oral antibiotics exist for the empirical treatment of extended-spectrum β-lactamase (ESBL) urinary tract infections (UTI). In this study, we sought to determine the activity of fosfomycin against ESBL-producing uropathogens from patients at 3 Veterans Affairs (VA) facilities between 2010 and 2013. Among the ESBL u...

journal_title：Antimicrobial agents and chemotherapy

authors： Linsenmeyer K,Strymish J,Weir S,Berg G,Brecher S,Gupta K

更新日期：2015-11-23 00:00:00

abstract：:TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of this study was to determine the pharmacokinetics (PK) and pharmacodynamics (PD) of TBR-652 in HIV-1-infected, antiretroviral treatment-experienced, CCR5 antagonist-naïve patients. A double-blind, placebo-controlled, randomized,...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier JF,Trinh M,Pheng LH,Palleja SM,Martin DE

更新日期：2011-06-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) of second-line antituberculosis drugs would allow for optimal individualized dosage adjustments and improve drug safety and therapeutic outcomes. To evaluate the pharmacokinetic (PK) characteristics of clinically relevant, multidrug treatment regimens and to improve the feasibility of...

journal_title：Antimicrobial agents and chemotherapy

authors： Park SI,Oh J,Jang K,Yoon J,Moon SJ,Park JS,Lee JH,Song J,Jang IJ,Yu KS,Chung JY

更新日期：2015-08-01 00:00:00

abstract：:BMY-28864, a water-soluble pradimicin derivative, had potent in vitro activity against a wide variety of fungi, including those associated with deep-seated mycosis; it inhibited the growth of standard strains and clinical isolates at concentrations of 12.5 micrograms/ml or less. At the MIC or higher concentrations, BM...

journal_title：Antimicrobial agents and chemotherapy

authors： Kakushima M,Masuyoshi S,Hirano M,Shinoda M,Ohta A,Kamei H,Oki T

更新日期：1991-11-01 00:00:00

abstract：:The introduction of reactive thiol groups in recombinant human tumor necrosis factor (TNF) alpha (rhTNF-alpha) by the reagent succinimidyl-S-acetylthioacetate resulted in the formation of a chemically stabilized rhTNF-alpha trimer (rhTNFalpha-AT; as determined by sodium dodecyl sulfate-polyacrylamide gel electrophores...

journal_title：Antimicrobial agents and chemotherapy

authors： Postma NS,Hermsen RC,Crommelin DJ,Eling WM,Zuidema J

更新日期：1999-05-01 00:00:00

abstract：:The objective of this study was to determine risk factors for the development of resistance to β-lactams/β-lactamase inhibitors (βL/βLIs) and ertapenem among Bacteroides species bacteremia. We conducted a retrospective case-control study of 101 adult patients with Bacteroides species bacteremia at a 1,051-bed tertiary...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith JM,Avdic E,Tamma PD,Zhang L,Carroll KC,Cosgrove SE

更新日期：2015-08-01 00:00:00

abstract：:The lipopeptidic antibiotic daptomycin is reported to reduce experimental tobramycin nephrotoxicity (D. Beauchamp, M. Pellerin, P. Gourde, M. Pettigrew and M. G. Bergeron, Antimicrob. Agents Chemother. 34:139-147, 1990; C. A. Wood, H. C. Finkbeiner, S. J. Kohlhepp, P. W. Kohnen, and D. C. Gilbert, Antimicrob. Agents C...

journal_title：Antimicrobial agents and chemotherapy

authors： Couture M,Simard M,Gourde P,Lessard C,Gurnani K,Lin L,Carrier D,Bergeron MG,Beauchamp D

更新日期：1994-04-01 00:00:00