Immunomodulation of pneumococcal pulmonary infection with N(G)-monomethyl-L-arginine.

abstract：:To assess the potential for the induction of antimicrobial resistance following repeated subinhibitory exposures to the combination minocycline (MIN), rifampin (RIF), and chlorhexidine (CHX), a total of 29 clinical microbial pathogenic isolates were repeatedly exposed to subinhibitory concentrations of MIN, RIF, and C...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosenblatt J,Vargas-Cruz N,Reitzel RA,Raad II

更新日期：2019-04-25 00:00:00

abstract：:Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion met...

journal_title：Antimicrobial agents and chemotherapy

authors： Andres S,Hillemann D,Rüsch-Gerdes S,Richter E

更新日期：2014-01-01 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00

abstract：:A novel staphylococcal cassette chromosome mec (SCCmec) composite island (SCCmecAI16-SCCczrAI16-CI) was identified in Staphylococcus pseudintermedius. Four integration site sequences for SCC subdivided the 60,734-bp island into 41,232-bp SCCmecAI16, 19,400-bp SCCczrAI16, and 102-bp SCC-likeAI16 elements. SCCmecAI16 re...

journal_title：Antimicrobial agents and chemotherapy

authors： Chanchaithong P,Prapasarakul N,Perreten V,Schwendener S

更新日期：2015-12-07 00:00:00

abstract：:The MICs of ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid for clinical isolates of Mycobacterium kansasii were determined by the radiometric (BACTEC) method. All drugs except azithromycin elicited MICs for 90% of the strains tested that were lower than previously reported achievable maximum c...

journal_title：Antimicrobial agents and chemotherapy

authors： Witzig RS,Franzblau SG

更新日期：1993-09-01 00:00:00

abstract：:Development of resistance to the antipseudomonal penicillins and cephalosporins mediated by hyperproduction of the chromosomal cephalosporinase AmpC is a major threat to the successful treatment of Pseudomonas aeruginosa infections. Although ampD inactivation has been previously found to lead to a partially derepresse...

journal_title：Antimicrobial agents and chemotherapy

authors： Juan C,Moyá B,Pérez JL,Oliver A

更新日期：2006-05-01 00:00:00

abstract：:The activity of the pradimicin derivative BMS 181184 was evaluated in a model of invasive pulmonary aspergillosis in persistently neutropenic rabbits and compared with that of amphotericin B deoxycholate. BMS 181184 at total daily doses of 50 and 150 mg/kg of body weight was at least as effective as amphotericin B at ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gonzalez CE,Groll AH,Giri N,Shetty D,Al-Mohsen I,Sein T,Feuerstein E,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-09-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:The effects of eight contact lens solutions on a Mastigina sp., which was associated with the infected eye of a patient, were studied. The solutions which killed the organism promptly were those which are used for gas-permeable and hard contact lenses. Some solutions for soft contact lenses were more effective than ot...

journal_title：Antimicrobial agents and chemotherapy

authors： Niszl IA,Markus MB,van Deventer JM

更新日期：1995-10-01 00:00:00

abstract：:The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was investigated. Phagocytes treated with SM-1213 demonstrated an enhanced ability to inhibit intracellular hyphal formation and elon...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrison CJ,Gordon P,Hashimoto T

更新日期：1984-07-01 00:00:00

abstract：:Detection of bacterial growth by measuring the release of (14)CO(2) from the metabolism of uniformly labeled (14)C-glucose has proven to be accurate, sensitive, and rapid. The inhibition of glucose metabolism by antibiotics as an index of bacterial susceptibility was evaluated based on radiometric methodology. Bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLand FH

更新日期：1972-11-01 00:00:00

abstract：:The emergence of resistant strains among common and rare Candida species necessitates continuous monitoring of the in vitro susceptibilities of those isolates. We therefore assessed the in vitro activities of micafungin against 1,099 molecularly identified isolates belonging to 5 common and 20 rare Candida species by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meletiadis J,Geertsen E,Curfs-Breuker I,Meis JF,Mouton JW

更新日期：2016-09-23 00:00:00

abstract：:The in vitro activity of BMS-207147 against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method. Geometric mean MICs (in microg/ml) were as follows: 1.71 for BMS-207147, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore CB,Walls CM,Denning DW

更新日期：2000-02-01 00:00:00

abstract：:The effect of a selected tripeptide, Z-d-Phe-Phe-Arg(NO(2)) (SV-4814) on the kinetics of lysis of green monkey erythrocytes by measles virus hemolysin suggested conditions of competitive inhibition. SV-4814 prevented not only hemoglobin release, but also the preceding leakage of K(+) through the cell membrane. The cap...

journal_title：Antimicrobial agents and chemotherapy

authors： Norrby E,Sievertsson H

更新日期：1974-04-01 00:00:00

abstract：:Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and c...

journal_title：Antimicrobial agents and chemotherapy

authors： Tabary X,Moreau N,Dureuil C,Le Goffic F

更新日期：1987-12-01 00:00:00

abstract：:As increasing numbers of colistin-resistant bacteria emerge, new therapies are urgently needed to treat infections caused by these pathogens. The discovery of new combination therapies is one important way to solve such problems. Here, we report that the antitumor drug PFK-158 and its analogs PFK-015 and 3PO can exert...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Wang X,Li X,Dong L,Hu X,Nie T,Lu Y,Lu X,Pang J,Li G,Yang X,Li C,You X

更新日期：2019-06-24 00:00:00

abstract：:The prevailing resistance mechanism against glycopeptides in Gram-positive pathogens involves reprogramming the biosynthesis of peptidoglycan precursors, resulting in d-alanyl-d-lactate depsipeptide termini. Amycolatopsis balhimycina produces the vancomycin-like glycopeptide balhimycin and therefore has to protect its...

journal_title：Antimicrobial agents and chemotherapy

authors： Schäberle TF,Vollmer W,Frasch HJ,Hüttel S,Kulik A,Röttgen M,von Thaler AK,Wohlleben W,Stegmann E

更新日期：2011-09-01 00:00:00

abstract：:The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Naughtin M,Dyason JC,Mardy S,Sorn S,von Itzstein M,Buchy P

更新日期：2011-05-01 00:00:00

abstract：:A clinical trial was designed to evaluate the efficacy and safety of cefotaxime, a new semisynthetic, broad-spectrum cephalosporin, in the therapy of community-and hospital-acquired pneumonias. Thirty-nine males (mean age, 65 years) were treated for 41 episodes of pneumonia. Only five patient did not have a serious un...

journal_title：Antimicrobial agents and chemotherapy

authors： Schleupner CJ,Engle JC

更新日期：1982-02-01 00:00:00

abstract：:Chloramphenicol-resistant strains of Bacteroides fragilis (minimum inhibitory concentration, 12.5 mug/ml) were isolated from a stool specimen which contained multiply resistant Escherichia coli. The enzyme responsible for resistance, chloramphenicol acetyltransferase, was produced constitutively by these strains; the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Britz ML,Wilkinson RG

更新日期：1978-07-01 00:00:00

abstract：:A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greates...

journal_title：Antimicrobial agents and chemotherapy

authors： de la Maza L,Ruoff KL,Ferraro MJ

更新日期：1989-08-01 00:00:00

abstract：:The effects of acid, oxgall, and H(2)O(2) on susceptibilities to antibiotics and nisin were examined for 13 strains of bifidobacteria. Susceptibilities to ampicillin, cloxacillin, penicillin, vancomycin, kanamycin, neomycin, paramomycin, streptomycin, chloramphenicol, erythromycin, tetracycline, and nisin A were assay...

journal_title：Antimicrobial agents and chemotherapy

authors： Kheadr E,Dabour N,Le Lay C,Lacroix C,Fliss I

更新日期：2007-01-01 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably les...

journal_title：Antimicrobial agents and chemotherapy

authors： Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

更新日期：1992-01-01 00:00:00

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:We examined 741 urinary tract isolates of the Morganella-Proteus-Providencia group, including the recently defined species Proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. The data emphasize the importance of identification to the species level on the basis of ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Cellini L,Allocati N,Di Girolamo A,Ravagnan G

更新日期：1987-10-01 00:00:00

abstract：:Pathogenic bacterial biofilms, such as those found in the lungs of patients with cystic fibrosis (CF), exhibit increased antimicrobial resistance, due in part to the inherent architecture of the biofilm community. The protection provided by the biofilm limits antimicrobial dispersion and penetration and reduces the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Habash MB,Park AJ,Vis EC,Harris RJ,Khursigara CM

更新日期：2014-10-01 00:00:00

abstract：:Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cef...

journal_title：Antimicrobial agents and chemotherapy

authors： Malik S,Kaminski M,Landman D,Quale J

更新日期：2020-10-20 00:00:00

abstract：:Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Caughey WS,Priola SA,Kocisko DA,Raymond LD,Ward A,Caughey B

更新日期：2007-11-01 00:00:00