Pharmacodynamics of metronidazole determined by a time-kill assay for Trichomonas vaginalis.

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

更新日期：1994-11-01 00:00:00

abstract：:Clinical treatment failures have been reported to occur in early Lyme borreliosis (LB) for many suitable antimicrobial agents. Investigations of possible resistance mechanisms of the Borrelia burgdorferi complex must analyze clinical isolates obtained from LB patients, despite their receiving antibiotic treatment. Her...

journal_title：Antimicrobial agents and chemotherapy

authors： Hunfeld KP,Ruzic-Sabljic E,Norris DE,Kraiczy P,Strle F

更新日期：2005-04-01 00:00:00

abstract：:A reverse-phase high-pressure liquid chromatography method for the quantitation of sulbactam in plasma, urine, and tissue is described. The assay used the formation of an imidazole derivative followed by extraction with acetonitrile and dichloromethane and used UV absorbance for detection. The mobile phase consisted o...

journal_title：Antimicrobial agents and chemotherapy

authors： Bawdon RE,Madsen PO

更新日期：1986-08-01 00:00:00

abstract：:The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos t...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindegardh N,Davies GR,Tran TH,Farrar J,Singhasivanon P,Day NP,White NJ

更新日期：2006-09-01 00:00:00

abstract：:Moderately penicillin-resistant Neisseria meningitidis was responsible for an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada in 1993. We tested fully susceptible and moderately resistant strains of N. meningitidis against ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, penicillin, and ri...

journal_title：Antimicrobial agents and chemotherapy

authors： Blondeau JM,Yaschuk Y

更新日期：1995-11-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:Retrospective analysis of 189 nonredundant strains of Pseudomonas aeruginosa sequentially recovered from the sputum samples of 46 cystic fibrosis (CF) patients over a 10-year period (1998 to 2007) revealed that 53 out of 189 (28%) samples were hypersusceptible to the beta-lactam antibiotic ticarcillin (MIC < or = 4 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Vettoretti L,Plésiat P,Muller C,El Garch F,Phan G,Attrée I,Ducruix A,Llanes C

更新日期：2009-05-01 00:00:00

abstract：:OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

更新日期：1998-11-01 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. In this study, we combined evolutionary sequence analyses, computational structural modeling, and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity difference...

journal_title：Antimicrobial agents and chemotherapy

authors： Dey D,Kavanaugh LG,Conn GL

更新日期：2020-07-22 00:00:00

abstract：:Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine if VPA affects the plasma concentration of efavirenz (EFV) or lopinavir. HIV type 1 (HIV-1)-infected patients receiving EFV or lopinavi...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson D,Cruttenden K,Morse G,Riggs G,Gelbard H,Schifitto G

更新日期：2004-11-01 00:00:00

abstract：:The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 30 to 500 nM; these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Meshnick SR

更新日期：1991-02-01 00:00:00

abstract：:In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rhee SY,Liu T,Ravela J,Gonzales MJ,Shafer RW

更新日期：2004-08-01 00:00:00

abstract：:The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic qui...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirai K,Aoyama H,Irikura T,Iyobe S,Mitsuhashi S

更新日期：1986-03-01 00:00:00

abstract：:The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Cherrington JM,Marthas ML,Berardi CJ,Mulato AS,Spinner A,Tarara RP,Canfield DR,Telm S,Bischofberger N,Pedersen NC

更新日期：1996-11-01 00:00:00

abstract：:BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pozzi C,De Luca F,Benvenuti M,Poirel L,Nordmann P,Rossolini GM,Mangani S,Docquier JD

更新日期：2016-11-21 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:Between February and June of 1997, a large number of community-acquired respiratory tract isolates of Haemophilus influenzae (n = 1,077) and Moraxella catarrhalis (n = 503) from 27 U.S. and 7 Canadian medical centers were characterized as part of the SENTRY Antimicrobial Surveillance Program. Overall prevalences of be...

journal_title：Antimicrobial agents and chemotherapy

authors： Doern GV,Jones RN,Pfaller MA,Kugler K

更新日期：1999-02-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:Increases in community-acquired infections caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. We developed and validated a tool for identifying patients harboring these organisms at hospital ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Bassetti M,De Rosa FG,Spanu T,Di Meco E,Losito AR,Parisini A,Pagani N,Cauda R

更新日期：2011-07-01 00:00:00

abstract：:We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Barth N,Ribeiro VB,Zavascki AP

更新日期：2015-01-01 00:00:00

abstract：:Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee A,Prideaux B,Lee MH,Zimmerman M,Dolgov E,Perlin DS,Zhao Y

更新日期：2019-05-24 00:00:00

abstract：:The telithromycin susceptibility of 210 erythromycin-resistant pneumococci was tested with the agar diffusion method. Twenty-six erm(B)-positive isolates showed heterogeneous resistance to telithromycin, which was manifested by the presence of colonies inside the inhibition zone. When these cells were cultured and tes...

journal_title：Antimicrobial agents and chemotherapy

authors： Rantala M,Haanperä-Heikkinen M,Lindgren M,Seppälä H,Huovinen P,Jalava J

更新日期：2006-05-01 00:00:00

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:The ribosome-targeting antimicrobial, spectinomycin (SPC), strongly induced the mexXY genes of the MexXY-OprM multidrug efflux system in Pseudomonas aeruginosa and increased susceptibility to the polycationic antimicrobials polymyxin B and polymyxin E, concomitant with a decrease in expression of the polymyxin resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Poole K,Lau CH,Gilmour C,Hao Y,Lam JS

更新日期：2015-12-01 00:00:00

abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

更新日期：1991-03-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains have spread worldwide and become a major threat in health care facilities. Transmission of blaKPC, the plasmid-borne KPC gene, can be mediated by clonal spread and horizontal transfer. Here, we report the complete nucleotide sequences of two nov...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen L,Chavda KD,Melano RG,Hong T,Rojtman AD,Jacobs MR,Bonomo RA,Kreiswirth BN

更新日期：2014-01-01 00:00:00

abstract：:Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study. These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Ojo KK,Ulep C,Van Kirk N,Luis H,Bernardo M,Leitao J,Roberts MC

更新日期：2004-09-01 00:00:00

abstract：:The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug efflux transporters. Raltegravir uptake, accumulation, and permeability were evaluated in vitro in (i) P-glycoprotein (P-gp), breast cancer resistance protein (BCRP...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoque MT,Kis O,De Rosa MF,Bendayan R

更新日期：2015-05-01 00:00:00