Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.

abstract：:We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether...

journal_title：Antimicrobial agents and chemotherapy

authors： Morris AA,Mueller SW,Rower JE,Washburn T,Kiser TH

更新日期：2015-10-01 00:00:00

abstract：:The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

journal_title：Antimicrobial agents and chemotherapy

authors： Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

更新日期：2015-07-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal subjects, pharmacokinetic data were calculated, using a two-compartment open body model. The mean distribution serum half...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroy A,Humbert G,Godin M,Fillastre JP

更新日期：1980-03-01 00:00:00

abstract：:R1033 is a plasmid of compatibility group P (= P1) transferred from a wild strain of Pseudomonas aeruginosa. It confers resistance to gentamicin by gentamicin acetyl-transferase 1 and to kanamycin and neomycin by neomycin phosphotransferase 1. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith DI,Lus RG,Rubio Calvo MC,Datta N,Jacob AE,Hedges RW

更新日期：1975-09-01 00:00:00

abstract：:The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatel...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou Z,Griffing SM,de Oliveira AM,McCollum AM,Quezada WM,Arrospide N,Escalante AA,Udhayakumar V

更新日期：2008-02-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:Liquid cultures of a Pseudomonas aeruginosa strain in Mueller-Hinton broth diluted at rates higher than the bacterial growth rate showed the expected decrease in CFU only for 1 to 2 h. Later the CFU started to increase. This phenomenon can be explained by a hypothesis that assumes that the bacteria multiply in two dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Haag R,Lexa P,Werkhäuser I

更新日期：1986-05-01 00:00:00

abstract：:FCE 22891 is the oral prodrug of FCE 22101, a new broad-spectrum penem. The pharmacokinetics of FCE 22891 after single-dose administration, its absolute bioavailability, and the effect of food intake on its absorption were investigated in three different randomized crossover studies in healthy volunteers. Drug levels ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saathoff A,Lode H,Hampel B,Deppermann KM,Borner K,Koeppe P

更新日期：1990-06-01 00:00:00

abstract：:The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain antibiotics require modified assay conditions in order to observe optimal activit...

journal_title：Antimicrobial agents and chemotherapy

authors： Kavanagh A,Ramu S,Gong Y,Cooper MA,Blaskovich MAT

更新日期：2018-12-21 00:00:00

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Abdelhamed AM,Good CE,Rhoads DD,Hujer KM,Hujer AM,Domitrovic TN,Rudin SD,Richter SS,van Duin D,Kreiswirth BN,Greco C,Fouts DE,Bonomo RA

更新日期：2018-12-21 00:00:00

abstract：:We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-...

journal_title：Antimicrobial agents and chemotherapy

authors： Uckun FM,Chelstrom LM,Tuel-Ahlgren L,Dibirdik I,Irvin JD,Langlie MC,Myers DE

更新日期：1998-02-01 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:A woman in her late 60s with disseminated histoplasmosis was treated with posaconazole because first-line therapies were not tolerated. She subsequently presented with decompensated heart failure, hypertension, and hypokalemia. Laboratory tests revealed low renin and aldosterone levels. A potential mechanism is inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuriakose K,Nesbitt WJ,Greene M,Harris B

更新日期：2018-04-26 00:00:00

abstract：:The in vitro activity of tebipenem (TBM), a new oral carbapenem antibiotic, against Streptococcus pneumoniae clinical isolates (n = 202) was compared with those of 15 reference agents. The isolates were classified into five genotypic classes after PCR identification of abnormal pbp1a, pbp2x, and pbp2b genes: (i) penic...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi R,Konomi M,Hasegawa K,Morozumi M,Sunakawa K,Ubukata K

更新日期：2005-03-01 00:00:00

abstract：:Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

更新日期：2019-08-23 00:00:00

abstract：:Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. O...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhai B,Wu C,Wang L,Sachs MS,Lin X

更新日期：2012-07-01 00:00:00

abstract：:We report here on a quantitative real-time reverse transcription-PCR (qRT-PCR) assay for assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum. The qRT-PCR assay detects 18S rRNA transcripts from both parasites, that is, the cycle threshold for 18S rRNA from parasites (C(T)([P18S])) and hos...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai X,Woods KM,Upton SJ,Zhu G

更新日期：2005-11-01 00:00:00

abstract：:Many gram-negative bacteria are known to be remarkably resistant to hydrophobic noxious agents by virtue of their outer membranes (OM). We investigated, by using four different assay methods, the ability of sodium hexametaphosphate (HMP) to disrupt this OM barrier. (i) In the growth inhibition assay, HMP was found to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Jaakkola J

更新日期：1989-10-01 00:00:00

abstract：:The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spangler SK,Lin G,Jacobs MR,Appelbaum PC

更新日期：1998-05-01 00:00:00

abstract：:A disk agar diffusion method was developed for testing the susceptibility of rapidly growing yeasts in vitro. A totally defined, completely synthetic agar culture medium (synthetic amino acid medium, fungal) and clinical isolates of Candida spp. and Torulopsis glabrata were used. Turbidimetric adjustment of cell suspe...

journal_title：Antimicrobial agents and chemotherapy

authors： Saubolle MA,Hoeprich PD

更新日期：1978-10-01 00:00:00

abstract：:Pseudomonas aeruginosa pneumonia remains a difficult therapeutic problem. Optimal doses and modes of administration of single agents often do not result in acceptable outcomes. Further, emergence of resistance occurs frequently in this setting with single-agent chemotherapy. The purpose of these experiments was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Liu W,Fikes S,Brown D,Drusano GL

更新日期：2013-06-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) are endemic in health care settings. These organisms colonize the gastrointestinal tract and can lead to infection which is associated with increased mortality. There is no treatment for VRE colonization. We conducted a randomized, double-blind, placebo-controlled clinical trial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Doron S,Hibberd PL,Goldin B,Thorpe C,McDermott L,Snydman DR

更新日期：2015-08-01 00:00:00

abstract：:Immunoprecipitation of antigens translated in vitro from Echinococcus granulosus RNA revealed that albendazole treatment of human hydatidosis induced antibodies to previously undetectable antigens and that the response to most antigens was specific, although cross-reactivity was observed between Schistosoma mansoni an...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanton RE,Okelo GB,Kijobe J,King CH

更新日期：1991-08-01 00:00:00

abstract：:Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. A target area under the concentration-time curve from 0 to 24 h (AUC0-24) of 40 to 50 μg · h/ml is recommended. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Q,Leroux S,Shi HY,Xu HY,Kou C,Khan MW,Jacqz-Aigrain E,Zhao W

更新日期：2018-04-26 00:00:00

abstract：:The Cpx stress response is widespread among Enterobacteriaceae We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA....

journal_title：Antimicrobial agents and chemotherapy

authors： Masi M,Pinet E,Pagès JM

更新日期：2020-05-21 00:00:00

abstract：:Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations that may be of clinical significance, especially during human immunodeficiency virus type 1 (HIV-1) and malaria coinfection. Using clinical isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lek-Uthai U,Suwanarusk R,Ruengweerayut R,Skinner-Adams TS,Nosten F,Gardiner DL,Boonma P,Piera KA,Andrews KT,Machunter B,McCarthy JS,Anstey NM,Price RN,Russell B

更新日期：2008-07-01 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Klein K,Grønnemose RB,Alm M,Brinch KS,Kolmos HJ,Andersen TE

更新日期：2017-06-27 00:00:00

abstract：:Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

更新日期：2008-09-01 00:00:00