Pharmacokinetics of FCE 22891, a new oral penem.

abstract：:The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-nonsusceptible Enterobacteriaceae (n = 1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n = 368), MD...

journal_title：Antimicrobial agents and chemotherapy

authors： Hackel MA,Tsuji M,Yamano Y,Echols R,Karlowsky JA,Sahm DF

更新日期：2018-01-25 00:00:00

abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

更新日期：2013-01-01 00:00:00

abstract：:The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrella M,Oliveira M,Moisi D,Detorio M,Brenner BG,Wainberg MA

更新日期：2004-11-01 00:00:00

abstract：:Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracyclin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lynch C,Courvalin P,Nikaido H

更新日期：1997-04-01 00:00:00

abstract：:A pyridodiazepine amine inhibitor of Helicobacter pylori glutamate racemase (MurI) was characterized. The compound was selectively active against H. pylori, and growth suppression was shown to be mediated through the inhibition of MurI by several methods. In killing kinetics experiments, the compound showed concentrat...

journal_title：Antimicrobial agents and chemotherapy

authors： de Jonge BL,Kutschke A,Newman JV,Rooney MT,Yang W,Cederberg C

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to characterize a novel extended-spectrum beta-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine residue at posi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Celenza G,De Santis F,Pellegrini C,Forcella C,Rossolini GM,Stefani S,Amicosante G

更新日期：2008-03-01 00:00:00

abstract：:Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

更新日期：2014-10-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:"Shock and kill" therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system. We have recently found several benzotri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sorensen ES,Macedo AB,Resop RS,Howard JN,Nell R,Sarabia I,Newman D,Ren Y,Jones RB,Planelles V,Spivak AM,Bosque A

更新日期：2020-07-22 00:00:00

abstract：:The global control of tuberculosis (TB) is at risk by the spread of multidrug-resistant TB (MDR TB). Treatment of MDR TB is lengthy and involves injected drugs, such as capreomycin, that have severe side effects. It was previously reported that a single daily dose of inhaled capreomycin had a positive effect on the ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Garcia-Contreras L,Muttil P,Fallon JK,Kabadi M,Gerety R,Hickey AJ

更新日期：2012-05-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:Accurate assessment of the risk factors for colonization with vancomycin-resistant enterococci (VRE) among high-risk patients is often confounded by nosocomial VRE transmission. We undertook a 15-month prospective cohort study of adults admitted to high-risk units (hematology, renal, transplant, and intensive care) in...

journal_title：Antimicrobial agents and chemotherapy

authors： Padiglione AA,Wolfe R,Grabsch EA,Olden D,Pearson S,Franklin C,Spelman D,Mayall B,Johnson PD,Grayson ML

更新日期：2003-08-01 00:00:00

abstract：:Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hernandez V,Crépin T,Palencia A,Cusack S,Akama T,Baker SJ,Bu W,Feng L,Freund YR,Liu L,Meewan M,Mohan M,Mao W,Rock FL,Sexton H,Sheoran A,Zhang Y,Zhang YK,Zhou Y,Nieman JA,Anugula MR,Keramane el M,Savariraj K,

更新日期：2013-03-01 00:00:00

abstract：:The chromosome-encoded class C β-lactamase CHE-1 produced by Enterobacter cloacae exhibits a lower sensitivity to avibactam than the P99 enzyme from which it is derived by a 6-residue deletion in the H-10 helix. In the present study, we investigated the sensitivity of CHE-1 to two other β-lactamase inhibitors: LK-157 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernea A,Galleni M,Frère JM

更新日期：2016-01-04 00:00:00

abstract：:The in vitro interactions between amikacin, netilmicin, tobramycin, gentamicin, and various antipseudomonal beta-lactams were studied by the agar dilution checkerboard technique against 30 Pseudomonas aeruginosa strains resistant to all tested antibiotics. Amikacin produced more frequent synergy both at the total and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Zissis NP,Tagari G,Bouzos J

更新日期：1984-04-01 00:00:00

abstract：:A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia...

journal_title：Antimicrobial agents and chemotherapy

authors： Rudolf D,Michaylov N,van der Linden M,Hoy L,Klugman KP,Welte T,Pletz MW,CAPNETZ Study Group.

更新日期：2011-10-01 00:00:00

abstract：:The three direct-acting antiviral agent (3D) regimen is a novel combination of direct-acting antiviral agents (DAAs) that has proven effective for the treatment of hepatitis C virus (HCV) infection. Given the potential for coadministration in patients with human immunodeficiency virus infection, possible drug interact...

journal_title：Antimicrobial agents and chemotherapy

authors： Khatri A,Dutta S,Dunbar M,Podsadecki T,Trinh R,Awni W,Menon R

更新日期：2016-04-22 00:00:00

abstract：:Ketoconazole, an oral antimycotic imidazole drug, blocked the transport of electrons in the respiratory chain of Candida albicans under aerobic conditions with different substrates, such as NADH and succinate. This effect was a nonspecific inhibition of NADH oxidases and succinate oxidases. The addition of ketoconazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Shigematsu ML,Uno J,Arai T

更新日期：1982-06-01 00:00:00

abstract：:Determination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocha PN,Macedo MN,Kobayashi CD,Moreno L,Guimarães LH,Machado PR,Badaró R,Carvalho EM,Glesby MJ

更新日期：2015-11-01 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:The aim of the study was to evaluate the penetration of ciprofloxacin into bronchial secretions from mechanically ventilated patients with nosocomial bronchopneumonia. For this purpose, in each patient studied, simultaneous serial blood and bronchial secretion samples were obtained over a 12-h period on days 2 and 4. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saux P,Martin C,Mallet MN,Papazian L,Bruguerolle B,De Micco P,Gouin F

更新日期：1994-04-01 00:00:00

abstract：:Acyclovir [9-(2-hydroxyethoxymethyl)guanine] (ACV), a potent antiviral compound, was phosphorylated to the same extent by extracts from untreated and iododeoxyuridine-treated Epstein-Barr virus-containing latent D98/HR-1 somatic hybrid cells. ATP was the preferred phosphate donor over other nucleoside triphosphates. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Datta AK,Pagano JS

更新日期：1983-07-01 00:00:00

abstract：:Cyclic peptides with an even number of alternating d,l-alpha-amino acid residues are known to self-assemble into organic nanotubes. Such peptides previously have been shown to be stable upon protease treatment, membrane active, and bactericidal and to exert antimicrobial activity against Staphylococcus aureus and othe...

journal_title：Antimicrobial agents and chemotherapy

authors： Dartois V,Sanchez-Quesada J,Cabezas E,Chi E,Dubbelde C,Dunn C,Granja J,Gritzen C,Weinberger D,Ghadiri MR,Parr TR Jr

更新日期：2005-08-01 00:00:00

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:A series of 11 fluoroquinolone antibacterial agents, including 8 newly synthesized molecules and 3 reference compounds (pefloxacin, ciprofloxacin, and sparfloxacin), were tested for their MICs against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The intracellular accumulation of fluoroquinolone...

journal_title：Antimicrobial agents and chemotherapy

authors： Bazile S,Moreau N,Bouzard D,Essiz M

更新日期：1992-12-01 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson JM,Prati F,Bethel CR,Bonomo RA

更新日期：2007-04-01 00:00:00

abstract：:A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Negri MC,Morosini MI,Baquero MR,del Campo R,Blázquez J,Baquero F

更新日期：2002-02-01 00:00:00

abstract：:Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy volunteers, using biomarkers for safety and efficacy. Subjects were ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallis RS,Jakubiec W,Kumar V,Bedarida G,Silvia A,Paige D,Zhu T,Mitton-Fry M,Ladutko L,Campbell S,Miller PF

更新日期：2011-02-01 00:00:00

abstract：:Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, each comprising eight healthy volunteers who received the following dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Krueger WA,Bulitta J,Kinzig-Schippers M,Landersdorfer C,Holzgrabe U,Naber KG,Drusano GL,Sörgel F

更新日期：2005-05-01 00:00:00

abstract：:The antimicrobial treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections has become a great challenge for medical staff all over the world. Increasing numbers of MDR A. baumannii infections have been identified and reported, but effective clinical treatments for them are decreasing. The objective of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai Y,Liu B,Wang T,Cai Y,Liang B,Wang R,Liu Y,Wang J

更新日期：2015-03-01 00:00:00