Penetration of ciprofloxacin into bronchial secretions from mechanically ventilated patients with nosocomial bronchopneumonia.

abstract：:Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, poor bioavailability, or drug resistance mechanism developed by the parasite. Thus...

journal_title：Antimicrobial agents and chemotherapy

authors： Spalenka J,Escotte-Binet S,Bakiri A,Hubert J,Renault JH,Velard F,Duchateau S,Aubert D,Huguenin A,Villena I

更新日期：2018-01-25 00:00:00

abstract：:Yersinia pestis is the etiologic agent of the plague. Reports of Y. pestis strains that are resistant to each of the currently approved first-line and prophylactic treatments point to the urgent need to develop novel antibiotics with activity against the pathogen. We previously reported that Y. pestis strain KIM6+, un...

journal_title：Antimicrobial agents and chemotherapy

authors： Steed DB,Liu J,Wasbrough E,Miller L,Halasohoris S,Miller J,Somerville B,Hershfield JR,Romesberg FE

更新日期：2015-07-01 00:00:00

abstract：:Polyamine levels are greatly increased in alveolar macrophages (AMs) during Pneumocystis pneumonia (PCP), leading to increased production of H(2)O(2), which causes AMs to undergo apoptosis. One of the mechanisms by which polyamine levels in AMs are elevated is enhanced uptake of exogenous polyamines. In this study, th...

journal_title：Antimicrobial agents and chemotherapy

authors： Liao CP,Phanstiel O 4th,Lasbury ME,Zhang C,Shao S,Durant PJ,Cheng BH,Lee CH

更新日期：2009-12-01 00:00:00

abstract：:Mitochondrial dysfunction in pathogenic fungi or model yeast causes altered susceptibilities to antifungal drugs. Here we have characterized the role of mitochondrial complex I (CI) of Candida albicans in antifungal susceptibility. Inhibitors of CI to CV, except for CII, increased the susceptibility of both patient an...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun N,Fonzi W,Chen H,She X,Zhang L,Zhang L,Calderone R

更新日期：2013-01-01 00:00:00

abstract：:We studied the effects of two N,N'-bis(benzyl)-substituted polyamine analogs on the capacities of Trypanosoma cruzi to invade and multiply within a mammalian host cell. At concentrations as low as 1 microM, these compounds reduced significantly the infectivity of the parasite for rat heart myoblasts in a time-dependen...

journal_title：Antimicrobial agents and chemotherapy

authors： Majumder S,Kierszenbaum F

更新日期：1993-10-01 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data for colistin are limited to guide dosing. The aim of this study was to develop a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee J,Han S,Jeon S,Hong T,Song W,Woo H,Yim DS

更新日期：2013-05-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes MR,McCulloch JA,Vianello MA,Moura Q,Pérez-Chaparro PJ,Esposito F,Sartori L,Dropa M,Matté MH,Lira DP,Mamizuka EM,Lincopan N

更新日期：2016-09-23 00:00:00

abstract：:A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dortet L,Bernabeu S,Gonzalez C,Naas T

更新日期：2017-07-25 00:00:00

abstract：:Amphotericin B colloidal dispersion (ABCD) is a new formulation of conventional amphotericin B designed to minimize drug distribution in the kidney and reduce nephrotoxicity. We studied the safety and efficacy of ABCD in 133 renally compromised patients with invasive fungal infections. Patients had either nephrotoxici...

journal_title：Antimicrobial agents and chemotherapy

authors： Anaissie EJ,Mattiuzzi GN,Miller CB,Noskin GA,Gurwith MJ,Mamelok RD,Pietrelli LA

更新日期：1998-03-01 00:00:00

abstract：:The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaehde U,Sörgel F,Stephan U,Schunack W

更新日期：1994-05-01 00:00:00

abstract：:Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Zebedee SL,Koduri RK,Mukherjee J,Mukherjee S,Lee S,Sauer DF,Scharff MD,Casadevall A

更新日期：1994-07-01 00:00:00

abstract：:Mycograb (NeuTec Pharma plc) is a human genetically recombinant antibody against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with recovery in patients with invasive candidiasis who are receiving amphotericin B (AMB). Using in vitro assays developed for efficacy assessment of chemother...

journal_title：Antimicrobial agents and chemotherapy

authors： Matthews RC,Rigg G,Hodgetts S,Carter T,Chapman C,Gregory C,Illidge C,Burnie J

更新日期：2003-07-01 00:00:00

abstract：:Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. The overall rate of beta-lactamase production was 95.3%. When the National...

journal_title：Antimicrobial agents and chemotherapy

authors： Doern GV,Brueggemann AB,Pierce G,Hogan T,Holley HP Jr,Rauch A

更新日期：1996-12-01 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:β-Lactams are often used to treat Helicobacter cinaedi infections; however, the mechanism underlying β-lactam resistance is unknown. In this study, we investigated β-lactam resistance in an H. cinaedi strain, MRY12-0051 (MICs of amoxicillin [AMX] and ceftriaxone [CRO], 32 and 128 μg/ml; obtained from human feces). Bas...

journal_title：Antimicrobial agents and chemotherapy

authors： Rimbara E,Mori S,Kim H,Suzuki M,Shibayama K

更新日期：2018-01-25 00:00:00

abstract：:Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydroartemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Salman S,Benjamin J,Page-Sharp M,Yadi G,Batty KT,Siba PM,Mueller I,Davis TM

更新日期：2015-07-01 00:00:00

abstract：:The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. The pharmacokinetic behavior of trimetrexate administered either by intravenous bolus or orally was studied...

journal_title：Antimicrobial agents and chemotherapy

authors： Rogers P,Allegra CJ,Murphy RF,Drake JC,Masur H,Poplack DG,Chabner BA,Parrillo JE,Lane HC,Balis FM

更新日期：1988-03-01 00:00:00

abstract：:Cefazolin was added to dialysis fluid in nine patients with renal failure undergoing peritoneal dialysis with 2 liters/h per exchange. With 50 mg/liter (three patients), the first measurable mean serum concentration was 3.7 mug/ml (range, 2.4 to 4.9 mug/ml) after three exchanges and was 30.3 mug/ml (range, 13.3 to 44....

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye D,Wenger N,Agarwal B

更新日期：1978-09-01 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Logan M,Cooper M,Ashby JP,Andrews JM

更新日期：1990-08-01 00:00:00

abstract：:Grazoprevir (GZR) plus elbasvir is an approved treatment for chronic infection with hepatitis C virus (HCV) genotype 1 or 4. HCV infection complications include liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The objective of this study was to evaluate the pharmacokinetics and safety of multipl...

journal_title：Antimicrobial agents and chemotherapy

authors： Caro L,Wenning L,Guo Z,Fraser IP,Fandozzi C,Talaty J,Panebianco D,Ho M,Uemura N,Reitmann C,Angus P,Gane E,Marbury T,Smith WB,Iwamoto M,Butterton JR,Yeh WW

更新日期：2017-11-22 00:00:00

abstract：:The nature of the SHV-1 beta-lactamase gene was analyzed in 97 epidemiologically unrelated Klebsiella pneumoniae strains isolated from clinical samples. beta-Lactamase bands that focused at a pI of 7.6 (SHV-1-type) in 74 strains, at a pI of 7.1 (LEN-1-type) in 13 strains, and at a pI of 5.4 (TEM-1-type) in 10 strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaves J,Ladona MG,Segura C,Coira A,Reig R,Ampurdanés C

更新日期：2001-10-01 00:00:00

abstract：:Acyclovir [9-(2-hydroxyethoxymethyl)guanine] (ACV), a potent antiviral compound, was phosphorylated to the same extent by extracts from untreated and iododeoxyuridine-treated Epstein-Barr virus-containing latent D98/HR-1 somatic hybrid cells. ATP was the preferred phosphate donor over other nucleoside triphosphates. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Datta AK,Pagano JS

更新日期：1983-07-01 00:00:00

abstract：:beta-Lactamase was purified from a strain of Legionella gormanii. The molecular weight of the purified enzyme was 25,000, and its isoelectric point was 10.5. The enzyme hydrolyzed oxyiminocephalosporins, cephamycins, penicillins, and imipenem. The enzyme activity was inhibited by EDTA, Hg2+, and Cu2+, but not by clavu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fujii T,Sato K,Miyata K,Inoue M,Mitsuhashi S

更新日期：1986-05-01 00:00:00

abstract：:CTX-M-1-producing Escherichia coli were isolated from 56 pigs, three farm personnel, two manure samples, and two air samples from two Danish pig farms where an association between prophylactic ceftiofur use and the occurrence of cephalosporin resistance was previously demonstrated. Human, animal, and environmental str...

journal_title：Antimicrobial agents and chemotherapy

authors： Moodley A,Guardabassi L

更新日期：2009-04-01 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 8...

journal_title：Antimicrobial agents and chemotherapy

authors： Fu KP,Neu HC

更新日期：1978-06-01 00:00:00

abstract：:We report 2 cases of recurrent Campylobacter coli enteritis caused by macrolide- and fluoroquinolone-resistant strains in 2 patients with hypogammaglobulinemia, successfully treated with a prolonged course of fosfomycin-tromethamine with no side effects. Fosfomycin-tromethamine may be a feasible alternative therapy fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aguilar-Company J,Los-Arcos I,Pigrau C,Rodríguez-Pardo D,Larrosa MN,Rodríguez-Garrido V,Sihuay-Diburga D,Almirante B

更新日期：2016-06-20 00:00:00