Prevalence of antimicrobial resistance among 723 outpatient clinical isolates of Moraxella catarrhalis in the United States in 1994 and 1995: results of a 30-center national surveillance study.

abstract：:The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and increased survival of...

journal_title：Antimicrobial agents and chemotherapy

authors： Tong JX,Ang SEL,Tan EHN,Tan KSW

更新日期：2019-03-27 00:00:00

abstract：:Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many prote...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura RL,Burlingame MA,Yang S,Crosby DC,Talbot DJ,Chui K,Frankel AD,Renslo AR

更新日期：2017-06-27 00:00:00

abstract：:Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahony DE,Lim-Morrison S,Bryden L,Faulkner G,Hoffman PS,Agocs L,Briand GG,Burford N,Maguire H

更新日期：1999-03-01 00:00:00

abstract：:A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1973-06-01 00:00:00

abstract：:Penetration of cefpiramide and cefazolin into a specific extravascular fluid was measured with rabbits bearing capsules in the peritoneal cavity. A general feature of slow accumulation and elimination of drugs from extravascular sites having low surface area/volume ratios has also been observed in this study. The caps...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsui H,Okuda T

更新日期：1988-01-01 00:00:00

abstract：:High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grégoire M,Dailly E,Le Turnier P,Garot D,Guimard T,Bernard L,Tattevin P,Vandamme YM,Hoff J,Lemaitre F,Verdier MC,Deslandes G,Bellouard R,Sébille V,Chiffoleau A,Boutoille D,Navas D,Asseray N

更新日期：2019-08-23 00:00:00

abstract：:Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol...

journal_title：Antimicrobial agents and chemotherapy

authors： Mayers M,Rush D,Madu A,Motyl M,Miller MH

更新日期：1991-09-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00

abstract：:The mechanism of colistin resistance (Col(r)) in Acinetobacter baumannii was studied by selecting in vitro Col(r) derivatives of the multidrug-resistant A. baumannii isolate AB0057 and the drug-susceptible strain ATCC 17978, using escalating concentrations of colistin in liquid culture. DNA sequencing identified mutat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams MD,Nickel GC,Bajaksouzian S,Lavender H,Murthy AR,Jacobs MR,Bonomo RA

更新日期：2009-09-01 00:00:00

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:The spread of extended-spectrum-beta-lactamase (ESBL)-producing organisms, particularly those harboring the CTX-M-type enzymes, both in the hospital and in the community, is difficult to discontinue due to the successful mobilization and evolution of the genetic elements harboring ESBL genes and coresistance rates in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Morosini MI,García-Castillo M,Coque TM,Valverde A,Novais A,Loza E,Baquero F,Cantón R

更新日期：2006-08-01 00:00:00

abstract：:BMS-207147, Sch 56592, and voriconazole are three new investigational triazoles with broad-spectrum antifungal activity. The in vitro activities of these three agents were compared with those of itraconazole and fluconazole against 1,300 bloodstream isolates of Candida species obtained from over 50 different medical c...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Messer SA,Hollis RJ,Jones RN,Doern GV,Brandt ME,Hajjeh RA

更新日期：1998-12-01 00:00:00

abstract：:Multiple injections of ofloxacin (subcutaneous or oral) in combination with a Lactobacillus casei preparation, LC9018 (subcutaneous), in mice infected intravenously with Mycobacterium fortuitum led to a marked delay in the incidence of spinning disease, a lowered incidence of gross renal lesions, and an increase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Sato K,Saito H

更新日期：1990-04-01 00:00:00

abstract：:MCC-478 is a newly synthesized 2-amino-6-arylthio-9-phosphonomethoxyethylpurine bis(2,2,2-trifluoroethyl) ester derivative. MCC-478 showed a substantially higher (ca. 80-fold) anti-hepatitis B virus (HBV) activity than that of lamivudine, despite no significant anti-human immunodeficiency virus activity. Since the bis...

journal_title：Antimicrobial agents and chemotherapy

authors： Kamiya N,Kubota A,Iwase Y,Sekiya K,Ubasawa M,Yuasa S

更新日期：2002-09-01 00:00:00

abstract：:Burkholderia pseudomallei, the causative agent of melioidosis, is inherently resistant to a variety of antibiotics including aminoglycosides, macrolides, polymyxins, and beta-lactam antibiotics. Despite resistance to many beta-lactams, ceftazidime and beta-lactamase inhibitor-beta-lactam combinations are commonly used...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Moore RA,Baker P,Woods DE

更新日期：2003-07-01 00:00:00

abstract：:Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunell M,Webber MA,Kotilainen P,Lilly AJ,Caddick JM,Jalava J,Huovinen P,Siitonen A,Hakanen AJ,Piddock LJ

更新日期：2009-09-01 00:00:00

abstract：:beta-Lactamases produced by urine isolates from patients in long-term care facilities (LTCFs), outpatient, clinics, and one hospital in a U.S. community were characterized. A total of 1.3% of all Escherichia coli and Klebsiella pneumoniae isolates collected from patients in 30 LTCFs and various outpatient clinics prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson ND,Moland ES,Hong SG,Propst K,Novak DJ,Cavalieri SJ

更新日期：2008-10-01 00:00:00

abstract：:Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against...

journal_title：Antimicrobial agents and chemotherapy

authors： Cottagnoud P,Cottagnoud M,Acosta F,Stucki A

更新日期：2013-10-01 00:00:00

abstract：:The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Kutlin A,Hammerschlag MR

更新日期：1997-09-01 00:00:00

abstract：:Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma bruceirhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an e...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiedemar N,Hauser DA,Mäser P

更新日期：2020-02-21 00:00:00

abstract：:The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

更新日期：2010-05-01 00:00:00

abstract：:The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embC...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Q,Xiao TY,Liu HC,Zhao XQ,Liu ZG,Li YN,Zeng H,Zhao LL,Wan KL

更新日期：2017-12-21 00:00:00

abstract：:Twenty-seven patients with advanced malignancies were given 200 mg of ketoconazole orally every 6 or 12 h. Blood samples were collected during these intervals and after the last dose to determine plasma concentrations and half-lives. The mean plasma concentrations measured after the initial dose were 1.7 +/- 1.1 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Maksymiuk AW,Levine HB,Bodey GP

更新日期：1982-07-01 00:00:00

abstract：:Selective decontamination of the digestive tract (SDD) has been evaluated as a method to prevent colonization and infection in ventilated patients in 40 trials. On the basis of an assumption that cross-infection would be reduced as a consequence of SDD and that this would distort the results of SDD studies that used c...

journal_title：Antimicrobial agents and chemotherapy

authors： Hurley JC

更新日期：1995-04-01 00:00:00

abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

journal_title：Antimicrobial agents and chemotherapy

authors： Everett MJ,Chopra I,Bennett PM

更新日期：1990-12-01 00:00:00

abstract：:Seventy nine strains of Yersinia enterocolitica resistant to one or more antimicrobials were analyzed for integrons. Only class 1 sul1 integrons containing aadA1a (28 strains), aadA1a-dfr1-sat1 (2 strains), and dfr1-aadA1a (1 strain) gene cassettes were found. The first two types were found in clinical isolates belong...

journal_title：Antimicrobial agents and chemotherapy

authors： Soto SM,Lobato MJ,Mendoza MC

更新日期：2003-01-01 00:00:00

abstract：:IncK plasmids encoding CTX-M-14 extended-spectrum β-lactamase (ESBL) and highly related to plasmid pCT were detected in 13 of 67 (19%) human clinical isolates of Escherichia coli with a group 9 CTX-M-type ESBL from the United Kingdom and in 2 quality assurance isolates. None of these E. coli strains was related to the...

journal_title：Antimicrobial agents and chemotherapy

authors： Dhanji H,Khan P,Cottell JL,Piddock LJ,Zhang J,Livermore DM,Woodford N

更新日期：2012-06-01 00:00:00

abstract：:Colistin is used to treat infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). It is administered intravenously in the form of colistin methanesulfonate (CMS), which is hydrolyzed in vivo to the active drug. However, pharmacokinetic data are limited. The aim of the present study was to characteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Plachouras D,Karvanen M,Friberg LE,Papadomichelakis E,Antoniadou A,Tsangaris I,Karaiskos I,Poulakou G,Kontopidou F,Armaganidis A,Cars O,Giamarellou H

更新日期：2009-08-01 00:00:00

abstract：:Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang GW,Brunel JM,Bolla JM,Van Bambeke F

更新日期：2020-12-14 00:00:00

abstract：:A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of m...

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Guiot HF,Mattie H,van Furth R

更新日期：1991-05-01 00:00:00