Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system.

abstract：:Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydroartemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Salman S,Benjamin J,Page-Sharp M,Yadi G,Batty KT,Siba PM,Mueller I,Davis TM

更新日期：2015-07-01 00:00:00

abstract：:Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Loos JA,Dávila VA,Brehm K,Cumino AC

更新日期：2020-08-20 00:00:00

abstract：:Maribavir (1263W94, VP-41263) is an oral anticytomegalovirus agent under clinical development. The pharmacokinetics and safety of maribavir and the effects of maribavir on the activities of cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2 (NAT-2), and xanthine oxidase (XO) were eval...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma JD,Nafziger AN,Villano SA,Gaedigk A,Bertino JS Jr

更新日期：2006-04-01 00:00:00

abstract：:Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial did not show that Carraguard is effective in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Romero JA,Abraham CJ,Rodriguez A,Kizima L,Jean-Pierre N,Menon R,Begay O,Seidor S,Ford BE,Gil PI,Peters J,Katz D,Robbiani M,Zydowsky TM

更新日期：2012-01-01 00:00:00

abstract：:The in vitro and in vivo activities of azithromycin against chlamydia were investigated. The MIC of azithromycin for five standard strains of different species of chlamydia and six wild-type strains of Chlamydia pneumoniae was 0.125 microgram/ml, which was superior to that of erythromycin but inferior to those of clar...

journal_title：Antimicrobial agents and chemotherapy

authors： Niki Y,Kimura M,Miyashita N,Soejima R

更新日期：1994-10-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of human immunodeficiency virus-infected patients at our hospital. The results from four patients who were on long-term (> or = 6 months) combination therapy with zidovudine an...

journal_title：Antimicrobial agents and chemotherapy

authors： Burger DM,Meenhorst PL,Koks CH,Beijnen JH

更新日期：1993-07-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00

abstract：:The aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obtained 30 min (n = 5)...

journal_title：Antimicrobial agents and chemotherapy

authors： Semoun O,Marchand S,Grégoire N,Lamarche I,Adier C,Laroche L,Goldschmidt P,Couet W

更新日期：2012-07-01 00:00:00

abstract：:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia...

journal_title：Antimicrobial agents and chemotherapy

authors： Ocampo AM,Chen L,Cienfuegos AV,Roncancio G,Chavda KD,Kreiswirth BN,Jiménez JN

更新日期：2015-10-26 00:00:00

abstract：:The in vitro activities of two investigational quinolones, sparfloxacin (previously designated AT 4140) and PD 127391, were determined for 30 strains each of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum and compared with those of ciprofloxacin, tetracycline, clindamycin, and erythromycin. Eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Duffy LB,Schmid T,Crabb D,Pate MS,Cassell GH

更新日期：1991-06-01 00:00:00

abstract：:Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

更新日期：2008-09-01 00:00:00

abstract：:A total of 100 and 97% of Haemophilus influenzae type b strains from major infections were susceptible, respectively, to levels of rifampin and sulfisoxazole attainable in saliva. It is theoretically feasible to eliminate Haemophilus influenzae from the nasopharynx with these drugs. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Cheung R

更新日期：1978-06-01 00:00:00

abstract：:Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmici...

journal_title：Antimicrobial agents and chemotherapy

authors： K N Lam P,Tian Q,Ip M,Gomersall CD

更新日期：2010-02-01 00:00:00

abstract：:The activities of niridazole and metronidazole were compared by an agar dilution method against 40 strains of Campylobacter fetus subsp. jejuni of human origin. Niridazole had a markedly higher activity than metronidazole. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Freydière AM,Gille Y,Tigaud S,Vincent P

更新日期：1984-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) Tat and gp120 intriguingly share the feature of being basic peptides that, once released by HIV(+) cells, bind to polyanionic heparan sulfate proteoglycans (HSPGs) on target uninfected cells, contributing to the onset of AIDS-associated pathologies. To identify multitarget anti-HIV p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bugatti A,Urbinati C,Ravelli C,De Clercq E,Liekens S,Rusnati M

更新日期：2007-07-01 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

更新日期：2012-06-01 00:00:00

abstract：:BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Sanada M,Matsuda K,Hashizume T,Asahi Y,Ushijima R,Ohtake N,Tanaka N

更新日期：1989-09-01 00:00:00

abstract：:Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance the...

journal_title：Antimicrobial agents and chemotherapy

authors： Robin F,Hennequin C,Gniadkowski M,Beyrouthy R,Empel J,Gibold L,Bonnet R

更新日期：2012-02-01 00:00:00

abstract：:Mutants of Escherichia coli K-12 that are unable to make use of the enterochelin transport system were used to confirm that streptonigrin requires iron for its bactericidal action. Correlation of viability studies and 55Fe3+ uptake experiments showed that killing by streptonigrin increased with an increase in 55Fe3+ u...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeowell HN,White JR

更新日期：1982-12-01 00:00:00

abstract：:Phosphonoformate (PF) at a concentration of 5 to 10 mug/ml inhibited the growth of type 1 strains of herpes simplex virus (HSV) in tissue culture, whereas 20 to 30 mug/ml was required for inhibition of type 2 strains and about 50 mug/ml was required for murine cytomegalovirus. In mice inoculated intraperitoneally or i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Glasgow LA,Overall JC Jr,Reno JM,Boezi JA

更新日期：1978-12-01 00:00:00

abstract：:The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure to metronidazole on the efficacy of a metronidazole-containing eradication regimen. Mice colonized with the metronidazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Jenks PJ,Labigne A,Ferrero RL

更新日期：1999-04-01 00:00:00

abstract：:Chryseobacterium gleum (previously included in the Flavobacterium IIb species) is a gram-negative aerobe that is a source of nosocomial infections. An Ambler class B beta-lactamase gene was cloned and expressed in Escherichia coli from reference strain C. gleum CIP 103039 that had reduced susceptibility to expanded-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Bellais S,Naas T,Nordmann P

更新日期：2002-09-01 00:00:00

abstract：:The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including bla(VIM-1), aacA7, aadA1, aadA2, dfrA1, dfrA12, aphA1, strA, strB, and sul1. Tn1000 or Tn5501 insertion within fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Miriagou V,Papagiannitsis CC,Kotsakis SD,Loli A,Tzelepi E,Legakis NJ,Tzouvelekis LS

更新日期：2010-10-01 00:00:00

abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

journal_title：Antimicrobial agents and chemotherapy

authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

更新日期：2017-10-24 00:00:00

abstract：:The in vitro susceptibility of Brucella melitensis was examined vis-a-vis the clinical outcome in 75 patients with brucellosis. The initial MICs for Brucella isolates from patients who relapsed and from those who did not were similar. Furthermore, the MICs for isolates from patients whose infections relapsed were no d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza J,Bosch J,Gudiol F,Liñares J,Viladrich PF,Martín R

更新日期：1986-12-01 00:00:00

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00

abstract：:In this study, our objective was to determine whether a synergistic antimicrobial combination in vitro would be beneficial in the downregulation of pneumococcal virulence genes and whether the associated inflammation of the lung tissue induced by multidrug-resistant Streptococcus pneumoniae infection in vivo needs to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Majhi A,Adhikary R,Bhattacharyya A,Mahanti S,Bishayi B

更新日期：2014-09-01 00:00:00