Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum.

abstract：:We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Asperg...

journal_title：Antimicrobial agents and chemotherapy

authors： Arikan S,Lozano-Chiu M,Paetznick V,Rex JH

更新日期：2001-01-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Towner KJ,Smith MA,Cowlishaw WA

更新日期：1983-04-01 00:00:00

abstract：:Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion met...

journal_title：Antimicrobial agents and chemotherapy

authors： Andres S,Hillemann D,Rüsch-Gerdes S,Richter E

更新日期：2014-01-01 00:00:00

abstract：:Three hundred ninety-four patients, aged 6 months to 12 years, entered a multicenter, randomized, controlled, investigator-blind study comparing cefdinir, 7 mg/kg of body weight twice a day, with cephalexin, 10 mg/kg four times a day, each given for 10 days. The most common infections treated were impetigo and seconda...

journal_title：Antimicrobial agents and chemotherapy

authors： Tack KJ,Keyserling CH,McCarty J,Hedrick JA

更新日期：1997-04-01 00:00:00

abstract：:Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their copr...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Ghilardi AC,Adams J,de Oliveira Garcia D,Paterson DL

更新日期：2007-09-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen that poses a significant risk to global health today. We have developed a promising new FtsZ-targeting agent (TXA707) with potent activity against MRSA isolates resistant to current standard-of-care antibiotics. We present here result...

journal_title：Antimicrobial agents and chemotherapy

authors： Ferrer-González E,Kaul M,Parhi AK,LaVoie EJ,Pilch DS

更新日期：2017-08-24 00:00:00

abstract：:Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have potentially serious toxicities, and when given as intramuscular injections, dosing can be painful. Adv...

journal_title：Antimicrobial agents and chemotherapy

authors： Dharmadhikari AS,Kabadi M,Gerety B,Hickey AJ,Fourie PB,Nardell E

更新日期：2013-06-01 00:00:00

abstract：:All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukar...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciarrocchi G,MacPhee DG,Deady LW,Tilley L

更新日期：1999-11-01 00:00:00

abstract：:Whole-genome sequencing of trimethoprim-resistant Escherichia coli clinical isolates identified a member of the trimethoprim-resistant type II dihydrofolate reductase gene family (dfrB). The dfrB4 gene was located within a class I integron flanked by multiple resistance genes. This arrangement was previously reported ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toulouse JL,Edens TJ,Alejaldre L,Manges AR,Pelletier JN

更新日期：2017-04-24 00:00:00

abstract：:A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation a...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Mugnaioli C,Luzzaro F,Fiore M,Stefani S,Rossolini GM,Amicosante G

更新日期：2005-04-01 00:00:00

abstract：:Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Sá Cavalcanti FL,Mendes-Marques CL,Vasconcelos CR,de Lima Campos T,Rezende AM,Xavier DE,Leal NC,de-Melo-Neto OP,de Morais MM,Leal-Balbino TC

更新日期：2016-12-27 00:00:00

abstract：:Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Borowski P,Lang M,Haag A,Schmitz H,Choe J,Chen HM,Hosmane RS

更新日期：2002-05-01 00:00:00

abstract：:Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Kariuki S,Okoro C,Kiiru J,Njoroge S,Omuse G,Langridge G,Kingsley RA,Dougan G,Revathi G

更新日期：2015-01-01 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galvez A,Valdivia E,Martinez M,Maqueda M

更新日期：1989-05-01 00:00:00

abstract：:Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime....

journal_title：Antimicrobial agents and chemotherapy

authors： Nannini EC,Stryjewski ME,Singh KV,Rude TH,Corey GR,Fowler VG Jr,Murray BE

更新日期：2010-05-01 00:00:00

abstract：:We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibac...

journal_title：Antimicrobial agents and chemotherapy

authors： Munoz-Price LS,Reeme AE,Buchan BW,Mettus RT,Mustapha MM,Van Tyne D,Shields RK,Doi Y

更新日期：2019-09-23 00:00:00

abstract：:The incidence of triazole-resistant Aspergillus infections is increasing worldwide, often mediated through mutations in the CYP51A amino acid sequence. New classes of azole-based drugs are required to combat the increasing resistance to existing triazole therapeutics. In this study, a CYP51 reconstitution assay is des...

journal_title：Antimicrobial agents and chemotherapy

authors： Warrilow AG,Parker JE,Price CL,Nes WD,Kelly SL,Kelly DE

更新日期：2015-12-01 00:00:00

abstract：:Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Campbell IG,Mee BJ

更新日期：1987-09-01 00:00:00

abstract：:The susceptibility of 49 strains of Clostridium ramosum to 10 antibiotics was determined by agar dilution and disk diffusion tests. Results showed that, among the anaerobes, C. ramosum is second only to Bacteroides fragilis in its resistance to antimicrobial agents. All strains were susceptible to penicillin, carbenic...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Armfield AY,Dowell VR Jr,Kwok YY,Sutter VL,Finegold SM

更新日期：1974-06-01 00:00:00

abstract：:The yeast Candida albicans is an opportunistic human fungal pathogen and the cause of superficial and systemic infections in immunocompromised patients. The classes of antifungal agents most commonly used to treat Candida infections are the azoles, polyenes, and echinocandins. In the present study, we identified chang...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoehamer CF,Cummings ED,Hilliard GM,Rogers PD

更新日期：2010-05-01 00:00:00

abstract：:(E)-(S)-4-((S)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-pent-4-ynoylamino)-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester (Compound 1) is a novel, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (Kobs/[I]) of 223,000 M-1s-1}. In cell-base...

journal_title：Antimicrobial agents and chemotherapy

authors： Patick AK,Brothers MA,Maldonado F,Binford S,Maldonado O,Fuhrman S,Petersen A,Smith GJ 3rd,Zalman LS,Burns-Naas LA,Tran JQ

更新日期：2005-06-01 00:00:00

abstract：:We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and their penicillin-derived components. Bactericidal activity was assayed and morpholo...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Cherubin CE

更新日期：1991-09-01 00:00:00

abstract：:beta-Lactamases produced by urine isolates from patients in long-term care facilities (LTCFs), outpatient, clinics, and one hospital in a U.S. community were characterized. A total of 1.3% of all Escherichia coli and Klebsiella pneumoniae isolates collected from patients in 30 LTCFs and various outpatient clinics prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson ND,Moland ES,Hong SG,Propst K,Novak DJ,Cavalieri SJ

更新日期：2008-10-01 00:00:00

abstract：:C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Wang JY,Xu C,Dong Y,Zhou J,Domagala J,Drlica K

更新日期：1998-04-01 00:00:00

abstract：:A total of 201 critically ill patients were studied during 267 courses of gentamicin or tobramycin treatment (139 gentamicin courses and 128 tobramycin courses). Of these 267 courses, pharmacokinetic and clinical data were obtained for 240 (120 gentamicin and 120 tobramycin). The data collected for pharmacokinetic ana...

journal_title：Antimicrobial agents and chemotherapy

authors： Schentag JJ,Plaut ME,Cerra FB

更新日期：1981-05-01 00:00:00

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:We recently identified a novel plasmid-mediated RND-type efflux pump gene cluster, tmexCD1-toprJ1 in Klebsiella pneumoniae, that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their function and tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang CZ,Gao X,Yang QW,Lv LC,Wan M,Yang J,Cai ZP,Liu JH

更新日期：2021-01-25 00:00:00