Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents.

abstract：:Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele...

journal_title：Antimicrobial agents and chemotherapy

authors： Yajko DM,Kirihara J,Sanders C,Nassos P,Hadley WK

更新日期：1988-09-01 00:00:00

abstract：:Adult diabetic patients admitted to our Diabetes Center from September 1996 to January 1998 for severe, limb-threatening foot infection were consecutively enrolled in a prospective, randomized, controlled clinical study aimed at assessing the safety and efficacy of recombinant human granulocyte colony-stimulating fact...

journal_title：Antimicrobial agents and chemotherapy

authors： de Lalla F,Pellizzer G,Strazzabosco M,Martini Z,Du Jardin G,Lora L,Fabris P,Benedetti P,Erle G

更新日期：2001-04-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto K,Yanagihara K,Sugahara K,Imamura Y,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Hirakata Y,Kamihira S,Kohno S

更新日期：2009-08-01 00:00:00

abstract：:Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez A,Poza M,Aranda J,Latasa C,Medrano FJ,Tomás M,Romero A,Lasa I,Bou G

更新日期：2012-12-01 00:00:00

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its union to the mitochondrial bc1 complex, preventing the ubiquinone-8,9 (UQ) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesis in Plasmodium falciparum and adopted proof-of-c...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdaguer IB,Crispim M,Zafra CA,Sussmann RAC,Buriticá NL,Melo HR,Azevedo MF,Almeida FG,Kimura EA,Katzin AM

更新日期：2021-01-25 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00

abstract：:Diethylpyrocarbonate (DEPC) treatment of interferon (IF) inducers was studied both in vitro and in vivo. DEPC did not affect the antiviral activity of poly(I.C), statolon, or reovirus in cultured chicken embryo fibroblast cells, but the activities of poly(I.C), statolon, and MU9 replicative form in cultured mouse embr...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamura Y,Cochran KW

更新日期：1976-04-01 00:00:00

abstract：:The binding of antibiotics to plasma (serum) proteins through hydrogen bonding can significantly influence the biological characteristics of these drugs. A rapid spectrophotometric assay has been developed that measures the level of free (unbound) penem antibiotic in serum ultrafiltrates. Whole human serum was adjuste...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Subashi TA,Lindner DL

更新日期：1988-02-01 00:00:00

abstract：:The prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Bártolo I,Rocha C,Bartolomeu J,Gama A,Fonseca M,Mendes A,Cristina F,Thamm S,Epalanga M,Silva PC,Taveira N

更新日期：2009-07-01 00:00:00

abstract：:We have previously shown that genetic disruption of Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3) affects calcium ionophore-induced egress. We examined whether Plasmodium falciparum CDPK1 (PfCDPK1), the closest homolog of TgCDPK3 in the malaria parasite P. falciparum, could complement a TgCDPK3 mutant...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaji RY,Checkley L,Reese ML,Ferdig MT,Arrizabalaga G

更新日期：2014-05-01 00:00:00

abstract：:Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

更新日期：2014-10-01 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00

abstract：:Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C...

journal_title：Antimicrobial agents and chemotherapy

authors： Liston SD,Whitesell L,Kapoor M,Shaw KJ,Cowen LE

更新日期：2020-04-21 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:The candidacidal activity of nitric oxide (NO) as delivered by a class of compounds termed diazeniumdiolates has been investigated. Diazeniumdiolates are stable agents capable of releasing NO in a biologically usable form at a predicted rate, and three such compounds were examined for activity. One compound, (Z)-1-[N-...

journal_title：Antimicrobial agents and chemotherapy

authors： McElhaney-Feser GE,Raulli RE,Cihlar RL

更新日期：1998-09-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:The activity of two cefoperazone-sulbactam combinations against anaerobic bacteria was tested and compared both with that of cefoperazone alone and with that of other commonly used antimicrobial agents. Imipenem was the most active of the tested agents, followed by chloramphenicol, metronidazole, and cefoperazone-sulb...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Finegold SM

更新日期：1988-03-01 00:00:00

abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

journal_title：Antimicrobial agents and chemotherapy

authors： Teuber M,Bader J

更新日期：1976-01-01 00:00:00

abstract：:The effect of antacid on the bioavailability of cefprozil was investigated in a two-way crossover study. Eight healthy male subjects received a single 500-mg oral dose of cefprozil with and without coadministration of 30 ml of an antacid suspension containing magnesium hydroxide and aluminum hydroxide (Maalox). Cefpro...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Wilber RB,Pittman KA,Barbhaiya RH

更新日期：1992-05-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00

abstract：:Mupirocin is a topical antibiotic used for the treatment of skin infections and the eradication of methicillin-resistant Staphylococcus aureus carriage. It inhibits bacterial protein synthesis by interfering with isoleucyl-tRNA synthetase activity. High-level mupirocin resistance (MIC of ≥ 512 μg/ml) is mediated by th...

journal_title：Antimicrobial agents and chemotherapy

authors： Seah C,Alexander DC,Louie L,Simor A,Low DE,Longtin J,Melano RG

更新日期：2012-04-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu S,Iyobe S,Mitsuhashi S

更新日期：1977-07-01 00:00:00

abstract：:Biofilm formation mediated by polysaccharide intercellular adhesin (PIA) is the major virulence factor of Staphylococcus epidermidis and is often associated with methicillin resistance. Transposon Tn917 insertions leading to a biofilm-negative phenotype in the biofilm-producing S. epidermidis strain 1457 (mecA-negativ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mack D,Sabottke A,Dobinsky S,Rohde H,Horstkotte MA,Knobloch JK

更新日期：2002-01-01 00:00:00

abstract：:The pharmacokinetics of an extended-release (XR) formulation of ciprofloxacin has been compared to that of the immediate-release (IR) product in healthy volunteers. The only significant difference in pharmacokinetic parameters between the two formulations was seen in the rate constant of absorption, which was approxim...

journal_title：Antimicrobial agents and chemotherapy

authors： Meagher AK,Forrest A,Dalhoff A,Stass H,Schentag JJ

更新日期：2004-06-01 00:00:00

abstract：:Determinants encoding resistance to antibiotics, except penicillin, of 5 of 21 Streptococcus anginosus clinical isolates that we examined transferred by conjugation into Enterococcus faecalis and into 1 to 5 streptococcal recipients at frequencies of 10(-6) to 10(-8) transconjugants per donor. No R plasmids were detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Clermont D,Horaud T

更新日期：1990-09-01 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00