Antiviral activities of MCC-478, a novel and specific inhibitor of hepatitis B virus.

abstract：:Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations among 139 MDR-TB iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao LL,Sun Q,Liu HC,Wu XC,Xiao TY,Zhao XQ,Li GL,Jiang Y,Zeng CY,Wan KL

更新日期：2015-04-01 00:00:00

abstract：:Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblas...

journal_title：Antimicrobial agents and chemotherapy

authors： Broeckel R,Sarkar S,May NA,Totonchy J,Kreklywich CN,Smith P,Graves L,DeFilippis VR,Heise MT,Morrison TE,Moorman N,Streblow DN

更新日期：2019-03-27 00:00:00

abstract：:The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively (with an MBC/MIC ratio of 1 to 2), and against 18 of the 21 species tested,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Labrousse V,Goh KS,De Sousa JP

更新日期：1991-12-01 00:00:00

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

journal_title：Antimicrobial agents and chemotherapy

authors： Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

更新日期：2015-07-01 00:00:00

abstract：:The effectiveness of Staphylococcus aureus strain 8325-4 as a recipient for the transduction of methicillin resistance requires the presence of a penicillinase plasmid but was found to be independent of the lysogenic state of the recipient. Effectiveness is conferred by the plasmid in either the autonomous or integrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Stewart GC,Rosenblum ED

更新日期：1980-09-01 00:00:00

abstract：:Gatifloxacin is an 8-methoxy fluoroquinolone effective against a broad spectrum of pathogens common in pediatric infections. The safety and pharmacokinetics of a single dose of gatifloxacin were studied in pediatric patients from 6 months to 16 years of age. Seventy-six pediatric patients (average age, 6.7 +/- 5.0 yea...

journal_title：Antimicrobial agents and chemotherapy

authors： Capparelli EV,Reed MD,Bradley JS,Kearns GL,Jacobs RF,Damle BD,Blumer JL,Grasela DM

更新日期：2005-03-01 00:00:00

abstract：:The release of inflammatory bacterial products, such as lipopolysaccharide (LPS)/endotoxin, may be increased upon the administration of antibiotics. An improved quantitative understanding of endotoxin release and its relation to antibiotic exposure and bacterial growth/killing may be gained by an integrated analysis o...

journal_title：Antimicrobial agents and chemotherapy

authors： Thorsted A,Tano E,Kaivonen K,Sjölin J,Friberg LE,Nielsen EI

更新日期：2020-03-24 00:00:00

abstract：:Sporadic isolates of carbapenem-resistant KPC-2-producing Klebsiella pneumoniae were isolated in Tel Aviv Medical Center during 2005 and 2006, parallel to the emergence of the KPC-3-producing K. pneumoniae sequence type 258 (ST 258). We aimed to study the molecular epidemiology of these isolates and to characterize th...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Carmeli Y,Chmelnitsky I,Goren MG,Ofek I,Navon-Venezia S

更新日期：2010-07-01 00:00:00

abstract：:Lamivudine [beta-L-(-)-2',3'-dideoxy-3'-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged therapy, indicating ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L

更新日期：2003-06-01 00:00:00

abstract：:Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause RNA chain termination. Here, we expand our studies on β-d-2'-C-methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ehteshami M,Tao S,Ozturk T,Zhou L,Cho JH,Zhang H,Amiralaei S,Shelton JR,Lu X,Khalil A,Domaoal RA,Stanton RA,Suesserman JE,Lin B,Lee SS,Amblard F,Whitaker T,Coats SJ,Schinazi RF

更新日期：2016-07-22 00:00:00

abstract：:A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effec...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindstedt M,Allenmark S,Thompson RA,Edebo L

更新日期：1990-10-01 00:00:00

abstract：:Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoyle BD,Alcantara J,Costerton JW

更新日期：1992-09-01 00:00:00

abstract：:The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

更新日期：1984-10-01 00:00:00

abstract：:In Cambodia, multidrug-resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria, and new therapeutic options are needed. Pyronaridine-artesunate has not previously been evaluated in eastern Cambodia. We conducted a single-arm, open-label, prospective study between July and December 2017 at the...

journal_title：Antimicrobial agents and chemotherapy

authors： Leang R,Mairet-Khedim M,Chea H,Huy R,Khim N,Mey Bouth D,Dorina Bustos M,Ringwald P,Witkowski B

更新日期：2019-02-26 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:The biliary excretion profile of cefixime was studied in 10 patients provided with T-tube drainage of the common bile duct after cholecystectomy. Following a single 200-mg oral dose, the peak concentration of cefixime in bile reached 56.9 +/- 70 mg/liter, approximately 20 times as high as the peak concentration in ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Westphal JF,Jehl F,Schloegel M,Monteil H,Brogard JM

更新日期：1993-07-01 00:00:00

abstract：:Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Caughey WS,Priola SA,Kocisko DA,Raymond LD,Ward A,Caughey B

更新日期：2007-11-01 00:00:00

abstract：:The iron-chelating drug deferoxamine (DFO) has been shown to be active in animal models of Pneumocystis carinii pneumonia (PCP), with effective daily intraperitoneal bolus dosages being 400 and 1,000 mg of DFO mesylate kg of body weight-1 in mouse and rat models, respectively. Continuous infusion produced a moderately...

journal_title：Antimicrobial agents and chemotherapy

authors： Merali S,Chin K,Del Angel L,Grady RW,Armstrong M,Clarkson AB Jr

更新日期：1995-09-01 00:00:00

abstract：:We assessed the activity and safety of liposomal nystatin, a broad-spectrum antifungal agent, for invasive aspergillosis in patients refractory to or intolerant of amphotericin B. Thirty-three patients were enrolled, received at least one dose of the study drug, and were evaluable for safety. Twenty-six patients had c...

journal_title：Antimicrobial agents and chemotherapy

authors： Offner F,Krcmery V,Boogaerts M,Doyen C,Engelhard D,Ribaud P,Cordonnier C,de Pauw B,Durrant S,Marie JP,Moreau P,Guiot H,Samonis G,Sylvester R,Herbrecht R,EORTC Invasive Fungal Infections Group.

更新日期：2004-12-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes serious illness (lower respiratory illness) in preterm infants. RSV antibody-enriched immunoglobulin (RSVIG) that was lyophilized (LYO) protected against RSV lower respiratory illness. The Food and Drug Administration now requires an additional viral inactivation step (VI). We ...

journal_title：Antimicrobial agents and chemotherapy

authors： Groothuis JR,Simoes EA,Lehr MV,Kramer AA,Hemming VG,Rodriguez WJ,Arrobio J,Welliver RC,Siber GR

更新日期：1995-03-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:The use of gentamicin to control contamination in a tissue culture system for the isolation of Chlamydia was investigated. Gentamicin, at concentrations up to 100 mug/ml, did not appear to inhibit the growth of stock chlamydial strains, as judged by assays for iodine-staining inclusions. When 343 cervical and urethral...

journal_title：Antimicrobial agents and chemotherapy

authors： Wentworth BB

更新日期：1973-06-01 00:00:00

abstract：:The recent reports of resistance in Plasmodium falciparum to artemisinin derivatives and their partner drugs demand intensive studies toward understanding the molecular mechanisms of resistance. In this study, we examined the in vitro susceptibility of 63 P. falciparum field isolates collected from the China-Myanmar b...

journal_title：Antimicrobial agents and chemotherapy

authors： Hao M,Jia D,Li Q,He Y,Yuan L,Xu S,Chen K,Wu J,Shen L,Sun L,Zhao H,Yang Z,Cui L

更新日期：2013-04-01 00:00:00

abstract：:Previous studies have shown that various short- and medium-chain free fatty acids (FFAs) and their corresponding monoacylglycerol esters (MGs) have antibacterial activity in vitro against primarily gram-positive bacteria. More recent studies have also shown that the growth of Helicobacter spp. is inhibited by linoleic...

journal_title：Antimicrobial agents and chemotherapy

authors： Petschow BW,Batema RP,Ford LL

更新日期：1996-02-01 00:00:00

abstract：:VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding site of PB2. VX-787 binds the cap-bi...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrn RA,Jones SM,Bennett HB,Bral C,Clark MP,Jacobs MD,Kwong AD,Ledeboer MW,Leeman JR,McNeil CF,Murcko MA,Nezami A,Perola E,Rijnbrand R,Saxena K,Tsai AW,Zhou Y,Charifson PS

更新日期：2015-03-01 00:00:00

abstract：:Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a neutropenic murine lung in...

journal_title：Antimicrobial agents and chemotherapy

authors： Crandon JL,Kuti JL,Nicolau DP

更新日期：2010-12-01 00:00:00

abstract：:Liquid cultures of a Pseudomonas aeruginosa strain in Mueller-Hinton broth diluted at rates higher than the bacterial growth rate showed the expected decrease in CFU only for 1 to 2 h. Later the CFU started to increase. This phenomenon can be explained by a hypothesis that assumes that the bacteria multiply in two dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Haag R,Lexa P,Werkhäuser I

更新日期：1986-05-01 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00