In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes.

abstract：:Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

更新日期：2012-06-01 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:Demethylchlortetracycline and, to a lesser extent, chlortetracycline were found to mediate the in vitro photoinactivation of Venezuelan equine encephalitis virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Esparza J,Pina CI,Novo E

更新日期：1976-07-01 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:The antifolate activity and the transport characteristics of isoaminopterin (IA) in HeLa cells were studied and compared with those of methotrexate (MTX). Both IA and MTX inhibited the incorporation of [2-(14)C]deoxyuridine into HeLa cell DNA by 50% at a concentration of 0.09 muM by 8 h postaddition of the compounds. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosemond-Hornbeak H,Nair MG

更新日期：1979-05-01 00:00:00

abstract：:We describe a primary high-throughput screen that uses the reporter strain Bacillus subtilis BAU-102 to identify antibiotics that induce autolysis. The screen measures autolysis in terms of the incipient release of recombinant Escherichia coli beta-galactosidase (beta-Gal) from the periplasmic space of B. subtilis owi...

journal_title：Antimicrobial agents and chemotherapy

authors： Falk SP,Noah JW,Weisblum B

更新日期：2010-09-01 00:00:00

abstract：:Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences o...

journal_title：Antimicrobial agents and chemotherapy

authors： McClure JC,Crothers ML,Schaefer JJ,Stanley PD,Needham GR,Ewing SA,Stich RW

更新日期：2010-12-01 00:00:00

abstract：:All cells need to protect themselves against the osmotic challenges of their environment by maintaining low permeability to ions across their cell membranes. This is a basic principle of cellular function, which is reflected in the interactions among ion transport and drug efflux genes that have arisen during cellular...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen BE

更新日期：2014-01-01 00:00:00

abstract：:Linezolid was tested against 32 species of uncommonly isolated gram-positive organisms (3,251 strains) by reference MIC methods and found to be highly active (MIC50 range, 0.25 to 2 microg/ml; MIC90 range, 0.25 to 2 microg/ml). Only one isolate (viridans group streptococcus; 0.03% of tested strains) was resistant to l...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Stilwell MG,Hogan PA,Sheehan DJ

更新日期：2007-04-01 00:00:00

abstract：:A simple technique with antibiotic-impregnated disks has been developed to demonstrate the antibiotic synergism of penicillins and aminoglycosides against enterococci. The two antibiotic disks are placed on inoculated plates so that the distance between their centers is less than the sum of the two radii of their prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee WS,Komarmy L

更新日期：1975-01-01 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estim...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupuis A,Limosin A,Paquereau J,Mimoz O,Couet W,Bouquet S

更新日期：2001-12-01 00:00:00

abstract：:Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Kariuki S,Okoro C,Kiiru J,Njoroge S,Omuse G,Langridge G,Kingsley RA,Dougan G,Revathi G

更新日期：2015-01-01 00:00:00

abstract：:In this study, the genetic organization of three novel genomic antibiotic resistance islands (AbaRs) in Acinetobacter baumannii isolates belonging to group of European clone II (EC II) comM integrated sequences of 18-, 21-, and 23-kb resistance islands were determined. These resistance islands carry the backbone of Ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Seputiene V,Povilonis J,Suziedeliene E

更新日期：2012-04-01 00:00:00

abstract：:Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NS...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciejka J,Milewska A,Wytrwal M,Wojarski J,Golda A,Ochman M,Nowakowska M,Szczubialka K,Pyrc K

更新日期：2016-03-25 00:00:00

abstract：:A radioimmunoassay system has been developed for the measurement of two major metabolites of 9,3"-diacetylmidecamycin, Mb-6 and Mb-12. A radioimmunoassay for Mb-6 was performed by using anti-Mb-6 serum and a [125I]tyramined Mb-6 derivative as a radiolabeled antigen. The labeled antigen was prepared by the chloramine T...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Ueda T,Yokoshima T,Umemura K,Shomura T

更新日期：1982-12-01 00:00:00

abstract：:The endoperoxides are a new class of antimalarial agents, of which artemisinin (qinghaosu) is the prototype. We have previously shown that artemisinin is capable of alkylating proteins in model reactions. In the present study, we showed that when Plasmodium falciparum-infected erythrocytes are treated with a radiolabe...

journal_title：Antimicrobial agents and chemotherapy

authors： Asawamahasakda W,Ittarat I,Pu YM,Ziffer H,Meshnick SR

更新日期：1994-08-01 00:00:00

abstract：:We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant, 523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and teicoplanin (MIC = 5 micrograms/ml) and elaborates a ca. 39-kDa cytoplasmic protein that was not detected in the parent strain 523 (MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski WM,Boyle-Vavra S,Moreira B,Ebert CC,Daum RS

更新日期：1996-01-01 00:00:00

abstract：:Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against...

journal_title：Antimicrobial agents and chemotherapy

authors： Cottagnoud P,Cottagnoud M,Acosta F,Stucki A

更新日期：2013-10-01 00:00:00

abstract：:Daptomycin is an investigational lipopeptide antibiotic active against gram-positive organisms. The mechanism of action is unique, resulting in interference with cell membrane transport. The bactericidal activity of daptomycin was evaluated against glycopeptide-intermediate susceptible Staphylococcus aureus (GISA), va...

journal_title：Antimicrobial agents and chemotherapy

authors： Akins RL,Rybak MJ

更新日期：2001-02-01 00:00:00

abstract：:PCR was used to amplify a 238-bp region from Helicobacter pylori which corresponded to the quinolone resistance-determining region in Escherichia coli. The gyrA gene of H. pylori was cloned and sequenced. An open reading frame of 2,478 nucleotides coded for a polypeptide of 826 amino acids with a calculated molecular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore RA,Beckthold B,Wong S,Kureishi A,Bryan LE

更新日期：1995-01-01 00:00:00

abstract：:Kingella kingae is the major pathogen causing osteoarticular infections (OAI) in young children in numerous countries. Plasmid-borne TEM-1 penicillinase production has been sporadically detected in a few countries but not in continental Europe, despite a high prevalence of K. kingae infections. We describe here for th...

journal_title：Antimicrobial agents and chemotherapy

authors： Basmaci R,Bidet P,Berçot B,Jost C,Kwon T,Gaumetou E,Bonacorsi S

更新日期：2014-10-01 00:00:00

abstract：:To evaluate the exposure-response relationships for efficacy and safety of voriconazole and anidulafungin in adult patients with invasive aspergillosis (IA), a population pharmacokinetic-pharmacodynamic (PK-PD) analysis was performed with data from a phase 3, prospective, double-blind, comparative study evaluating vor...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu P,Mould DR

更新日期：2014-08-01 00:00:00

abstract：:Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with t...

journal_title：Antimicrobial agents and chemotherapy

authors： Markantonis SL,Markou N,Fousteri M,Sakellaridis N,Karatzas S,Alamanos I,Dimopoulou E,Baltopoulos G

更新日期：2009-11-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:The pharmacokinetics and metabolism of 3'-azido-3'-deoxythymidine (AZT) were investigated in rhesus monkeys after subcutaneous administration of 33.3 mg of AZT per kg of body weight alone or in the presence of 100 mg of probenecid per kg. In addition to unchanged drug, two catabolites, 5'-O-glucuronide (GAZT) and 3'-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Cretton EM,Schinazi RF,McClure HM,Anderson DC,Sommadossi JP

更新日期：1991-05-01 00:00:00

abstract：:The incidence of triazole-resistant Aspergillus infections is increasing worldwide, often mediated through mutations in the CYP51A amino acid sequence. New classes of azole-based drugs are required to combat the increasing resistance to existing triazole therapeutics. In this study, a CYP51 reconstitution assay is des...

journal_title：Antimicrobial agents and chemotherapy

authors： Warrilow AG,Parker JE,Price CL,Nes WD,Kelly SL,Kelly DE

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to clarify the clarithromycin resistance mechanisms of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae strains. In all clarithromycin-resistant strains, the transcript level of acrB was significantly elevated, and these strains had a frameshift mutation in acrR Introducti...

journal_title：Antimicrobial agents and chemotherapy

authors： Seyama S,Wajima T,Nakaminami H,Noguchi N

更新日期：2016-04-22 00:00:00

abstract：:The complete sequence of the carbapenem-resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain is presented. pLD209 is formed by 3 well-defined regions: an adaptability module encompassing a Tn402-like class 1 integron of clinical origin containing blaVIM-2 and aacA4 gene cassettes,...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchiaro PM,Brambilla L,Morán-Barrio J,Revale S,Pasteran F,Vila AJ,Viale AM,Limansky AS

更新日期：2014-01-01 00:00:00