Novel variants of AbaR resistance islands with a common backbone in Acinetobacter baumannii isolates of European clone II.

abstract：:Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion met...

journal_title：Antimicrobial agents and chemotherapy

authors： Andres S,Hillemann D,Rüsch-Gerdes S,Richter E

更新日期：2014-01-01 00:00:00

abstract：:Fluoroquinolones are antibiotics with central excitatory side effects. These adverse effects presumably result from inhibition of gamma-aminobutyric acid (GABA) binding to GABA(A) receptors. This GABA antagonistic effect is greatly potentiated by the active metabolite of fenbufen, biphenylacetic acid (BPAA). Neverthel...

journal_title：Antimicrobial agents and chemotherapy

authors： Smolders I,Gousseau C,Marchand S,Couet W,Ebinger G,Michotte Y

更新日期：2002-02-01 00:00:00

abstract：:Carbapenemase-producing Enterobacteriaceae isolates (n = 110) from health care centers in central Indiana (from 2010 to 2013) were tested for susceptibility to combinations of avibactam (4 μg/ml) with ceftazidime, ceftaroline, or aztreonam. MIC50/MIC90 values were 1/2 μg/ml (ceftazidime-avibactam), 0.5/2 μg/ml (ceftar...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Kashikar A,Brown CA,Denys G,Bush K

更新日期：2017-07-25 00:00:00

abstract：:We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. The degree of potentiation as estimated by standard isobolar...

journal_title：Antimicrobial agents and chemotherapy

authors： Winter RW,Cornell KA,Johnson LL,Ignatushchenko M,Hinrichs DJ,Riscoe MK

更新日期：1996-06-01 00:00:00

abstract：:The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldberg I,Walker JR,Bloch K

更新日期：1973-05-01 00:00:00

abstract：:Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

journal_title：Antimicrobial agents and chemotherapy

authors： Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

更新日期：2008-11-01 00:00:00

abstract：:The susceptibility of 53 clinical isolates of Bacteroides fragilis to cephamycins was examined. Judging from the MICs for 50% of the strains tested, moxalactam was the most active, however, judging from the MICs for 90% of the strains tested, cefbuperazone was more effective than moxalactam. A correlation was observed...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Minami S,Kakizawa H,Yasuda T,Takai A,Saikawa I,Inoue M,Mitsuhashi S

更新日期：1985-12-01 00:00:00

abstract：:VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding site of PB2. VX-787 binds the cap-bi...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrn RA,Jones SM,Bennett HB,Bral C,Clark MP,Jacobs MD,Kwong AD,Ledeboer MW,Leeman JR,McNeil CF,Murcko MA,Nezami A,Perola E,Rijnbrand R,Saxena K,Tsai AW,Zhou Y,Charifson PS

更新日期：2015-03-01 00:00:00

abstract：:The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP; dehydropeptidase I)...

journal_title：Antimicrobial agents and chemotherapy

authors： Keynan S,Hooper NM,Felici A,Amicosante G,Turner AJ

更新日期：1995-07-01 00:00:00

abstract：:The multiple antibiotic resistance (mar) locus in Escherichia coli consists of two divergently expressed operons (marC and marRAB), both of which contribute to the Mar phenotype. Overexpression of the marRAB operon protected E. coli against rapid cell killing by fluoroquinolones. Inactivation of the operon in mar muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldman JD,White DG,Levy SB

更新日期：1996-05-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:We encountered three clinical isolates of methicillin-resistant Staphylococcus aureus which were susceptible to netilmicin and arbekacin in the absence of beta-lactam antibiotics but which were resistant to them in the presence of beta-lactam antibiotics. One of these strains, KU5801, was used to further investigate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Ida T,Okamoto R,Nonoyama M,Irinoda K,Kurazono M,Inoue M

更新日期：2002-05-01 00:00:00

abstract：:Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular st...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarkar S,Uppuluri P,Pierce CG,Lopez-Ribot JL

更新日期：2014-01-01 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:An uncoupler of oxidative phosphorylation, 2,4-dinitrophenol, and an aconitase inhibitor, fluoroacetic acid, both of which are known to lower the cellular ATP pool, protected Escherichia coli cells from the bactericidal actions of gyrase poisons including quinolone antibiotics, nalidixic acid and ciprofloxacin, and th...

journal_title：Antimicrobial agents and chemotherapy

authors： Li TK,Liu LF

更新日期：1998-05-01 00:00:00

abstract：:Pseudomonas aeruginosa clinical isolate CY-1, which was resistant to ceftazidime, harbored a conjugative ca. 250-kb plasmid that contained a class 1 integron with two gene cassettes encoding OXA-32, an OXA-2- type beta-lactamase, and the aminoglycoside acetyltransferase AAC(6')Ib(9). OXA-32 differed from OXA-2 by an L...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Gerome P,De Champs C,Stephanazzi J,Naas T,Nordmann P

更新日期：2002-02-01 00:00:00

abstract：:Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Molina-Quiroz RC,Lazinski DW,Camilli A,Levy SB

更新日期：2016-10-21 00:00:00

abstract：:The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galvez A,Valdivia E,Martinez M,Maqueda M

更新日期：1989-05-01 00:00:00

abstract：:In 2016, we identified a new class A carbapenemase, VCC-1, in a nontoxigenic Vibrio cholerae strain that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1-producing V. cholerae isolates were recovered along the German coastline. These isolates a...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangat CS,Vadlamani G,Holicek V,Chu M,Larmour VLC,Vocadlo DJ,Mulvey MR,Mark BL

更新日期：2019-03-27 00:00:00

abstract：:RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC90s of RBx 11760 and linezolid against Staphylococcus aureus were 2 and 4 mg/liter, against Staphylococcus epidermidis were 0.5 and 2 mg/liter, and against Enterococcus were 1 and 4 mg/liter, respecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Barman TK,Kumar M,Mathur T,Chaira T,Ramkumar G,Kalia V,Rao M,Pandya M,Yadav AS,Das B,Upadhyay DJ,Hamidullah,Konwar R,Raj VS,Singh H

更新日期：2016-11-21 00:00:00

abstract：:Candida albicans and Staphylococcus aureus form vigorous polymicrobial biofilms in serum, which may serve as the source of coinfection in patients. More importantly, S. aureus is highly resistant to vancomycin during polymicrobial biofilm formation, with no decreases in bacterial viability observed with up to 1,600 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2010-09-01 00:00:00

abstract：:Ribonucleic acid (RNA) synthesis in the sorbitol-dependent, fragile yeast mutant VY1160 (Venkov et al., 1974) is rapidly inhibited by rifampin. The growth of the mutant cells and protein synthesis are more slowly affected by the antibiotic, apparently as secondary phenomena. Lower doses of rifampin (50 to 100 mug/ml) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkov PV,Milchev GI,Hadjiolov AA

更新日期：1975-12-01 00:00:00

abstract：:We investigated whether cells derived from the fetal central nervous system can support productive infection by a human immunodeficiency virus type 1 (HIV-1) isolate termed UHC-1, produced by a cellular clone derived from HIV-1 strain HIV-IIIB chronically infected U-937 promonocytic cells, and what the effect of nucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Geleziunas R,Arts EJ,Boulerice F,Goldman H,Wainberg MA

更新日期：1993-06-01 00:00:00

abstract：:Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapen...

journal_title：Antimicrobial agents and chemotherapy

authors： Egelund EF,Weiner M,Singh RP,Prihoda TJ,Gelfond JA,Derendorf H,Mac Kenzie WR,Peloquin CA

更新日期：2014-08-01 00:00:00

abstract：:Enzymes in the ergosterol-biosynthetic pathway are the targets of a number of antifungal agents including azoles, allylamines, and morpholines. In order to understand the response of Saccharomyces cerevisiae to perturbations in the ergosterol pathway, genome-wide transcript profiles following exposure to a number of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Bammert GF,Fostel JM

更新日期：2000-05-01 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:A clinical isolate of Enterobacter cloacae, strain NOR-1, exhibited resistance to imipenem and remained susceptible to extended-spectrum cephalosporins. Clavulanic acid partially restored the susceptibility of the strain to imipenem. Two beta-lactamases with isoelectric points (pI) of 6.9 and > 9.2 were detected in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Nordmann P,Mariotte S,Naas T,Labia R,Nicolas MH

更新日期：1993-05-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Coenye T,Honraet K,Rigole P,Nadal Jimenez P,Nelis HJ

更新日期：2007-04-01 00:00:00

abstract：:The pharmacokinetics and protein binding of ceforanide were studied in 15 patients undergoing cholecystectomies. Each patient received ceforanide (20 mg/kg) intravenously on arrival in the operating room, after which serial blood samples were collected during the elimination phase for determination of total and free c...

journal_title：Antimicrobial agents and chemotherapy

authors： DiPiro JT,Bayoumi SM,Vallner JJ,Nesbit RR,Gokhale R,Rissing JP

更新日期：1985-04-01 00:00:00