Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.

abstract：:Actithiazic acid and alpha-methyldethiobiotin inhibited the conversion of dethiobiotin to biotin resting-cell suspensions of Escherichia coli. The concentrations which effected 50% inhibition were 0.45 and 1.1 microM for actithiazic acid and alpha-methyldethiobiotin, respectively. Cells grown in low concentrations of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eisenberg MA,Hsiung SC

更新日期：1982-01-01 00:00:00

abstract：:Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Somma S,Merati W,Parenti F

更新日期：1977-03-01 00:00:00

abstract：:Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracyclin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lynch C,Courvalin P,Nikaido H

更新日期：1997-04-01 00:00:00

abstract：:Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic. Our experience with once-daily gentamicin, 6 mg/kg of body weight led to a 10% (3 of 33 patients) occurrence of documented ototoxicity after prolonged aminoglycoside exposure. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Singer C,Smith C,Krieff D

更新日期：1996-09-01 00:00:00

abstract：:Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

journal_title：Antimicrobial agents and chemotherapy

authors： Lau AH,Chang CW,Sabatini S

更新日期：1986-02-01 00:00:00

abstract：:We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

更新日期：2020-12-14 00:00:00

abstract：:Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DCK,Guo I,Burrows LL

更新日期：2020-02-21 00:00:00

abstract：:The biological activity of a new intravenous (i.v.) preparation of human vaccinia immune globulin (VIGIV) was evaluated in two mouse models of vaccinia virus (VV) infection. In a mouse tail lesion model, female CD-1 mice were inoculated i.v. with 7 x 10(4) PFU of VV to produce >10 lesions per tail 8 days later. In a m...

journal_title：Antimicrobial agents and chemotherapy

authors： Shearer JD,Siemann L,Gerkovich M,House RV

更新日期：2005-07-01 00:00:00

abstract：:Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infe...

journal_title：Antimicrobial agents and chemotherapy

authors： Lionakis MS,Albert ND,Swamydas M,Lee CR,Loetscher P,Kontoyiannis DP

更新日期：2017-02-23 00:00:00

abstract：:Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hill GB

更新日期：1976-02-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Ropp PA,Hu M,Olesky M,Nicholas RA

更新日期：2002-03-01 00:00:00

abstract：:The bla(TLA-1) gene encoding an extended-spectrum beta-lactamase was identified in 11 enterobacterial isolates from Mexico City, Mexico. This gene was located on different plasmids and plasmid types with different sizes and incompatibility groups. It was associated with a novel insertion sequence, ISCR20, encoding a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Berçot B,Poirel L,Silva-Sanchez J,Nordmann P

更新日期：2010-09-01 00:00:00

abstract：:We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate th...

journal_title：Antimicrobial agents and chemotherapy

authors： Baumann RJ,McCann PP,Bitonti AJ

更新日期：1991-07-01 00:00:00

abstract：:Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Rank LA,Walsh NM,Liu R,Lim FY,Bok JW,Huang M,Keller NP,Gellman SH,Hull CM

更新日期：2017-09-22 00:00:00

abstract：:The increasing use of carbapenems for treating multidrug-resistant (MDR) Gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Serine and metallo-β-lactamases (MBLs) that hydrolyze carbapenems have become prevalent and endemic in some countries...

journal_title：Antimicrobial agents and chemotherapy

authors： Bradford PA,Kazmierczak KM,Biedenbach DJ,Wise MG,Hackel M,Sahm DF

更新日期：2015-12-14 00:00:00

abstract：:Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang W,Li Y,Qian G,Wang Y,Chen H,Li YZ,Liu F,Shen Y,Du L

更新日期：2011-12-01 00:00:00

abstract：:Pefloxacin has been shown to have good intraocular penetration when given systemically. In order to extend its clinical use, we have assessed the tolerability, kinetics, and efficacy of subconjunctival pefloxacin in phakic pigmented rabbits. The tolerability of a single subconjunctival injection of pefloxacin (0.8, 1....

journal_title：Antimicrobial agents and chemotherapy

authors： Marrakchi-Benjaafar S,Cochereau I,D'Hermies F,Pocidalo JJ

更新日期：1995-04-01 00:00:00

abstract：:Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under sel...

journal_title：Antimicrobial agents and chemotherapy

authors： Orlén H,Hughes D

更新日期：2006-10-01 00:00:00

abstract：:A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime...

journal_title：Antimicrobial agents and chemotherapy

authors： Schneider I,Queenan AM,Markovska R,Markova B,Keuleyan E,Bauernfeind A

更新日期：2009-10-01 00:00:00

abstract：:We report here on a quantitative real-time reverse transcription-PCR (qRT-PCR) assay for assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum. The qRT-PCR assay detects 18S rRNA transcripts from both parasites, that is, the cycle threshold for 18S rRNA from parasites (C(T)([P18S])) and hos...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai X,Woods KM,Upton SJ,Zhu G

更新日期：2005-11-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in developing countries. Measles outbreaks also occur in some developed countries that have failed to maintain high vaccine cov...

journal_title：Antimicrobial agents and chemotherapy

authors： Plemper RK,Doyle J,Sun A,Prussia A,Cheng LT,Rota PA,Liotta DC,Snyder JP,Compans RW

更新日期：2005-09-01 00:00:00

abstract：:Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were classified into type A and type B, based on the degrees of changes in their susceptibilities. Type A mutants were four to eight times more resistant to ofloxacin, erythromycin, and new zwitterion...

journal_title：Antimicrobial agents and chemotherapy

authors： Masuda N,Gotoh N,Ohya S,Nishino T

更新日期：1996-04-01 00:00:00

abstract：:Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eron LJ,Toy C,Salsitz B,Scheer RR,Wood DL,Nadler PI

更新日期：1987-07-01 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00