Tolerability, kinetics, and efficacy of subconjunctival pefloxacin in pigmented rabbits.

abstract：:Recalcitrant dermatophytoses are on the rise in India. High MICs of terbinafine (TRB) and squalene epoxidase (SQLE) gene mutations conferring resistance in Trichophyton spp. have been recently documented. However, studies correlating laboratory data with clinical response to TRB in tinea corporis/cruris are lacking. F...

journal_title：Antimicrobial agents and chemotherapy

authors： Khurana A,Masih A,Chowdhary A,Sardana K,Borker S,Gupta A,Gautam RK,Sharma PK,Jain D

更新日期：2018-11-26 00:00:00

abstract：:Replication of measles virus in BSC cells was studied in the presence of enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether), a commonly used volatile anesthetic agent, and its isomer, isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). At clinical concentrations of the anesthetics (up to 4%), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knight PR,Nahrwold ML,Bedows E

更新日期：1981-09-01 00:00:00

abstract：:The efficacy and safety of a novel once-daily extended-release ciprofloxacin (ciprofloxacin ER) 500-mg dose were compared with those of an immediate-release ciprofloxacin (ciprofloxacin IR) 250-mg twice-daily dose, each administered orally for 3 days in the treatment of acute uncomplicated urinary tract infection (uUT...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourcroy JL,Berner B,Chiang YK,Cramer M,Rowe L,Shore N

更新日期：2005-10-01 00:00:00

abstract：:Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metab...

journal_title：Antimicrobial agents and chemotherapy

authors： Hufford CD,Baker JK,McChesney JD,Clark AM

更新日期：1986-08-01 00:00:00

abstract：:Twenty-three healthy male and female subjects received single 100-mg oral doses of rimantadine hydrochloride on two occasions in an open-label, sequential design with a 6-day washout between doses. The first dose of rimantadine was administered alone, and the second dose was administered concomitantly with cimetidine ...

journal_title：Antimicrobial agents and chemotherapy

authors： Holazo AA,Choma N,Brown SY,Lee LF,Wills RJ

更新日期：1989-06-01 00:00:00

abstract：:The nucleoprotein (NP) binds the viral RNA genome and associates with the polymerase in a ribonucleoprotein complex (RNP) required for transcription and replication of influenza A virus. NP has no cellular counterpart, and the NP sequence is highly conserved, which led to considering NP a hot target in the search for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lejal N,Tarus B,Bouguyon E,Chenavas S,Bertho N,Delmas B,Ruigrok RW,Di Primo C,Slama-Schwok A

更新日期：2013-05-01 00:00:00

abstract：:Amoxicillin was studied in normal subjects after intravenous, oral, and intramuscular administration of 250-, 500-, and 1,000-mg doses. Serum drug levels were analyzed using a two-compartment open model, as well as area under the curve (AUC) and urinary recovery. The variations of these pharmacokinetic parameters were...

journal_title：Antimicrobial agents and chemotherapy

authors： Spyker DA,Rugloski RJ,Vann RL,O'Brien WM

更新日期：1977-01-01 00:00:00

abstract：:Solithromycin (CEM-101) is a new antibiotic that is highly potent against Ureaplasma and Mycoplasma spp. and active against many other antibiotic-resistant organisms. We have explored the maternal-amniotic-fetal pharmacokinetics of CEM-101 in a pregnant sheep model to assess its potential for treating intrauterine and...

journal_title：Antimicrobial agents and chemotherapy

authors： Keelan JA,Kemp MW,Payne MS,Johnson D,Stock SJ,Saito M,Fernandes P,Newnham JP

更新日期：2014-01-01 00:00:00

abstract：:Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal structure of the larg...

journal_title：Antimicrobial agents and chemotherapy

authors： Berisio R,Corti N,Pfister P,Yonath A,Böttger EC

更新日期：2006-11-01 00:00:00

abstract：:The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA pol...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross SL,Moses RE

更新日期：1976-02-01 00:00:00

abstract：:A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes MR,McCulloch JA,Vianello MA,Moura Q,Pérez-Chaparro PJ,Esposito F,Sartori L,Dropa M,Matté MH,Lira DP,Mamizuka EM,Lincopan N

更新日期：2016-09-23 00:00:00

abstract：:We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Szabó D,Silveira F,Hujer AM,Bonomo RA,Hujer KM,Marsh JW,Bethel CR,Doi Y,Deeley K,Paterson DL

更新日期：2006-08-01 00:00:00

abstract：:In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutio...

journal_title：Antimicrobial agents and chemotherapy

authors： Bougnoux ME,Dannaoui E,Accoceberry I,Angoulvant A,Bailly E,Botterel F,Chevrier S,Chouaki T,Cornet M,Dalle F,Datry A,Dupuis A,Fekkar A,Gangneux JP,Guitard J,Hennequin C,Le Govic Y,Le Pape P,Maubon D,Ranque S,Sautou

更新日期：2016-07-22 00:00:00

abstract：:The efficacy of an itraconazole-cyclodextrin solution against Aspergillus fumigatus was assessed in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis and compared with that of amphotericin B. Oral itraconazole solution at dosages of 20 and 40 mg/kg/day improved survival as compared wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Patterson TF,Fothergill AW,Rinaldi MG

更新日期：1993-11-01 00:00:00

abstract：:The pharmacokinetics of cefepime were studied in 12 adult patients in intensive care units during continuous venovenous hemofiltration (CVVH) or continuous venovenous hemodiafiltration (CVVHDF) with a Multiflow60 AN69HF 0.60-m(2) polyacrylonitrile hollow-fiber membrane (Hospal Industrie, Meyzieu, France). Patients (me...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-11-01 00:00:00

abstract：:Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA mutations (A90V, A90V-S...

journal_title：Antimicrobial agents and chemotherapy

authors： Giannoni F,Iona E,Sementilli F,Brunori L,Pardini M,Migliori GB,Orefici G,Fattorini L

更新日期：2005-07-01 00:00:00

abstract：:The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

更新日期：1989-08-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:SM-7338, a new carbapenem antibiotic, was demonstrated to have potent antibacterial activity against a broad spectrum of aerobes, including Staphylococcus aureus, beta-hemolytic streptococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp., members of the family Enterobacteriaceae, Pseudomonas spp., a...

journal_title：Antimicrobial agents and chemotherapy

authors： Edwards JR,Turner PJ,Wannop C,Withnell ES,Grindey AJ,Nairn K

更新日期：1989-02-01 00:00:00

abstract：:There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration of daptomycin in patients with suspected or documented neurosurgical infections. We conducted a prospective study, assessing the pharmacokinetics and CSF penetration of a single intravenous daptomycin dose administered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kullar R,Chin JN,Edwards DJ,Parker D,Coplin WM,Rybak MJ

更新日期：2011-07-01 00:00:00

abstract：:Community-onset (CO) candidemia, defined as a positive blood culture taken at or within 2 days of hospital admission, represents a distinct clinical entity associated with substantial morbidity and mortality. Reference MIC results from the SENTRY Antimicrobial Surveillance Program (2008-2009) were analyzed to compare ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Moet GJ,Messer SA,Jones RN,Castanheira M

更新日期：2011-02-01 00:00:00

abstract：:We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Coenye T,Honraet K,Rigole P,Nadal Jimenez P,Nelis HJ

更新日期：2007-04-01 00:00:00

abstract：:The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitr...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Shea IP,Shahed M,Aguilera-Venegas B,Wilkinson SR

更新日期：2015-11-23 00:00:00

abstract：:beta-Lactamase was purified from a strain of Legionella gormanii. The molecular weight of the purified enzyme was 25,000, and its isoelectric point was 10.5. The enzyme hydrolyzed oxyiminocephalosporins, cephamycins, penicillins, and imipenem. The enzyme activity was inhibited by EDTA, Hg2+, and Cu2+, but not by clavu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fujii T,Sato K,Miyata K,Inoue M,Mitsuhashi S

更新日期：1986-05-01 00:00:00

abstract：:Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahony DE,Lim-Morrison S,Bryden L,Faulkner G,Hoffman PS,Agocs L,Briand GG,Burford N,Maguire H

更新日期：1999-03-01 00:00:00

abstract：:The Bacteroides fragilis bacteriocin which inhibits ribonucleic acid (RNA) polymerase activity had a narrow activity spectrum in vivo and only inhibited the growth of certain B. fragilis strains. In vitro the bacteriocin was not specific and inhibited RNA polymerases from widely diverse bacterial genera. RNA polymeras...

journal_title：Antimicrobial agents and chemotherapy

authors： Mossie KG,Robb FT,Jones DT,Woods DR

更新日期：1981-10-01 00:00:00

abstract：:We previously demonstrated the efficacy of ceftriaxone (CRO), at 50 mg/kg of body weight every 12 h, against a highly penicillin-resistant (MIC, 4 micrograms/ml) Streptococcus pneumoniae strain with low-level resistance to CRO (MIC, 0.5 microgram/ml) in a leukopenic-mouse pneumonia model (P. Moine, E. Vallée, E. Azoul...

journal_title：Antimicrobial agents and chemotherapy

authors： Sauve C,Azoulay-Dupuis E,Moine P,Darras-Joly C,Rieux V,Carbon C,Bédos JP

更新日期：1996-12-01 00:00:00

abstract：:An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5 splicing and/or IE4...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulka M,Smith CC,Levis J,Fishelevich R,Hunter JC,Cushman CD,Miller PS,Ts'o PO,Aurelian L

更新日期：1994-04-01 00:00:00

abstract：:Enzyme-mediated immunoassay (EMIT) serum aminoglycoside assay results were accurate and precise and correlated well with radioimmunoassay, fluoroimmunoassay, and acetyltransferase and microbiological assay determinations. ...

journal_title：Antimicrobial agents and chemotherapy

authors： White LO,Scammell LM,Reeves DS

更新日期：1981-06-01 00:00:00

abstract：:Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protei...

journal_title：Antimicrobial agents and chemotherapy

authors： Honoré N,Cole ST

更新日期：1994-02-01 00:00:00