Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1.

abstract：:Xylitol is effective in preventing acute otitis media by inhibiting the growth of Streptococcus pneumoniae. To clarify this inhibition we used fructose, which is known to block similar growth inhibition observed in Streptococcus mutans. In addition, we evaluated the efficacy of sorbitol in inhibiting the growth of pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Tapiainen T,Kontiokari T,Sammalkivi L,Ikäheimo I,Koskela M,Uhari M

更新日期：2001-01-01 00:00:00

abstract：:We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficac...

journal_title：Antimicrobial agents and chemotherapy

authors： Mario DN,Guarro J,Santurio JM,Alves SH,Capilla J

更新日期：2015-08-01 00:00:00

abstract：:We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Luca MC,D'Ercole S,Petrelli D,Prenna M,Ripa S,Vitali LA

更新日期：2010-10-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:Topical blockade of the gp41 fusogenic protein of HIV-1 is one possible strategy by which microbicides could prevent HIV transmission, working early against infection, by inhibiting viral entry into host cells. In this study, we examined the potential of gp41 fusion inhibitors (FIs) as candidate anti-HIV microbicides....

journal_title：Antimicrobial agents and chemotherapy

authors： Harman S,Herrera C,Armanasco N,Nuttall J,Shattock RJ

更新日期：2012-05-01 00:00:00

abstract：:(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays perfo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gu Z,Wainberg MA,Nguyen-Ba N,L'Heureux L,de Muys JM,Bowlin TL,Rando RF

更新日期：1999-10-01 00:00:00

abstract：:A global sample of group A streptococci (GAS) revealed > or =80 separate acquisitions of tetracycline resistance. Of 244 clones, 38 and 25% displayed resistance to tetracycline and erythromycin, respectively; a relatively high proportion (15%) were resistant to both classes of drugs. tet(M) displayed a highly signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Ayer V,Tewodros W,Manoharan A,Skariah S,Luo F,Bessen DE

更新日期：2007-05-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent. For many years, the risk of disease reemergence was thought to solely be through deliberate misuse of VARV strains kept in clandestine laboratories. Howev...

journal_title：Antimicrobial agents and chemotherapy

authors： Delaune D,Iseni F

更新日期：2020-03-24 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention. A total of 9 of 78 Ch-P-treated subjects and 26 of 52 subjects who received no prophylaxis contra...

journal_title：Antimicrobial agents and chemotherapy

authors： Gozal D,Hengy C,Fadat G

更新日期：1991-02-01 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:Thein vitroantibacterial activities of ceftazidime-avibactam and comparator agents were evaluated using reference broth microdilution methods against 1,743Pseudomonas aeruginosaisolates collected in 2014 from 69 U.S. medical centers, representing each of the nine census regions. Ceftazidime-avibactam demonstrated pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Huband MD,Castanheira M,Flamm RK,Farrell DJ,Jones RN,Sader HS

更新日期：2016-03-25 00:00:00

abstract：:The in vitro activities of three newly developed quinolone drugs (T-3262, NY-198, and fleroxacin [AM-833; RO 23-6240]) against 10 strains of clinically isolated Chlamydia trachomatis were assessed and compared with those of other quinolones and minocycline. T-3262 (MIC for 90% of isolates tested, 0.1 microgram/ml) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Maeda H,Fujii A,Nakata K,Arakawa S,Kamidono S

更新日期：1988-07-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:The in vitro susceptibilities of 112 clinical isolates of Haemophilus ducreyi to six antimicrobial agents were determined. These isolates were obtained in Kigali, Rwanda, during three studies on genital ulcer disease performed in 1986 (18 isolates), 1988 (23 isolates), and 1991 (71 isolates). All H. ducreyi isolates w...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Dyck E,Bogaerts J,Smet H,Tello WM,Mukantabana V,Piot P

更新日期：1994-07-01 00:00:00

abstract：:Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalosporinase from Enter...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Freudenberger JS,Sykes RB

更新日期：1982-09-01 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Szabó D,Silveira F,Hujer AM,Bonomo RA,Hujer KM,Marsh JW,Bethel CR,Doi Y,Deeley K,Paterson DL

更新日期：2006-08-01 00:00:00

abstract：:The postantibiotic subminimum inhibitory concentration effect (PA SME) may simulate in vivo drug exposure more accurately than the postantibiotic effect (PAE) since subinhibitory concentrations of drug persist between antibiotic dosings. In this study, we compared the PAEs and PA SMEs of levofloxacin and ciprofloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Licata L,Smith CE,Goldschmidt RM,Barrett JF,Frosco M

更新日期：1997-05-01 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:Surveillance of the circulating Mycobacterium tuberculosis complex (MTC) strains in a given locality is important for understanding tuberculosis (TB) epidemiology. We performed molecular epidemiological studies on sputum smear-positive isolates that were collected for anti-TB drug resistance surveillance to establish ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lukoye D,Katabazi FA,Musisi K,Kateete DP,Asiimwe BB,Okee M,Joloba ML,Cobelens FG

更新日期：2014-07-01 00:00:00

abstract：:Four species of members of the family Enterobacteriaceae harboring extended-spectrum beta-lactamase (ESBL) were recovered in a single patient hospitalized in an intensive care unit. Among these isolates, we describe for the first time an ESBL-producing Providencia rettgeri strain. Bacteria from the same species were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchandin H,Carriere C,Sirot D,Pierre HJ,Darbas H

更新日期：1999-08-01 00:00:00

abstract：:As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-beta-lactamase, designated VIM-7. bla(VIM-7) is located on a 24-kb plasmid which can be readily transferred into Enterobacteriaceae and other pseudomonads. This is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toleman MA,Rolston K,Jones RN,Walsh TR

更新日期：2004-01-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bei ZC,Li GF,Zhao JH,Zhang M,Ji XG,Wang JY

更新日期：2020-10-20 00:00:00

abstract：:The antibiotic susceptibilities of 43 strains of Escherichia coli O157:H7 identified in the summer of 1996 in Japan were investigated. Growth of 90% of O157 strains was inhibited at a concentration of < or = 0.5 micro/ml by several agents including fosfomycin with glucose-6-phosphate. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuboi I,Ida H,Yoshikawa E,Hiyoshi S,Yamaji E,Nakayama I,Nonomiya T,Shigenobu F,Shimizu M,O'Hara K,Sawai T,Mizuoka K

更新日期：1998-02-01 00:00:00

abstract：:The antibacterial activity of octenidine dihydrochloride (WIN 41464-2) against intact preformed in vitro plaques of four indigenous oral plaque-forming microorganisms, Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, and Actinomyces naeslundii, was studied. Both absolute (plaque bactericidal index) a...

journal_title：Antimicrobial agents and chemotherapy

authors： Slee AM,O'Connor JR

更新日期：1983-03-01 00:00:00

abstract：:The purpose of this study was to assess the effect of voriconazole on the blood tacrolimus concentration in a liver transplant recipient and to examine the interaction between voriconazole and tacrolimus by using human liver microsomes. Two subjects were enrolled in the clinical study: one received voriconazole, and t...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkataramanan R,Zang S,Gayowski T,Singh N

更新日期：2002-09-01 00:00:00

abstract：:The activity of the pradimicin derivative BMS 181184 was evaluated in a model of invasive pulmonary aspergillosis in persistently neutropenic rabbits and compared with that of amphotericin B deoxycholate. BMS 181184 at total daily doses of 50 and 150 mg/kg of body weight was at least as effective as amphotericin B at ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gonzalez CE,Groll AH,Giri N,Shetty D,Al-Mohsen I,Sein T,Feuerstein E,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-09-01 00:00:00