Abstract:
:We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Mario DN,Guarro J,Santurio JM,Alves SH,Capilla Jdoi
10.1128/AAC.00052-15subject
Has Abstractpub_date
2015-08-01 00:00:00pages
5018-21issue
8eissn
0066-4804issn
1098-6596pii
AAC.00052-15journal_volume
59pub_type
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