Biochemical properties of beta-lactamase produced by Legionella gormanii.

abstract：:Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. Because bacterial resistance to rifampin may develop rapidly, its widespread use could result in the emergence of a resistant flora. This study evaluates the effectiveness of rifampin in reducing the nasal carri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sande MA,Mandell GL

更新日期：1975-03-01 00:00:00

abstract：:A collection of 2,278 isolates belonging to 86 different fungal species was tested with micafungin and eight other drugs using the EUCAST procedures. Micafungin was active against species of Candida and Aspergillus (even azole-resistant species) as well as Penicillium spp., Scedosporium apiospermum, and Acremonium spp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Mellado E,Monzon A,Buitrago MJ,Rodriguez-Tudela JL

更新日期：2009-05-01 00:00:00

abstract：:A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously on...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzariol A,Roelofsen E,Koncan R,Voss A,Cornaglia G

更新日期：2007-03-01 00:00:00

abstract：:The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

journal_title：Antimicrobial agents and chemotherapy

authors： Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

更新日期：2007-05-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:The most deadly outbreak of Escherichia coli O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2(cycl) in a murine model of E. coli O104:H4 infection. Systemic treatment with Retro-2(cycl) significantly reduced body weight loss and improved clinical scores...

journal_title：Antimicrobial agents and chemotherapy

authors： Secher T,Shima A,Hinsinger K,Cintrat JC,Johannes L,Barbier J,Gillet D,Oswald E

更新日期：2015-08-01 00:00:00

abstract：:The antiviral effects of selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide, selenazole), ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), and 3-deazaguanosine (6-amino-1-beta-D-ribofuranosylimidazo-[4.5-C]pyridin-4(5H)-one) were investigated separately and in various combinations in an in v...

journal_title：Antimicrobial agents and chemotherapy

authors： Kirsi JJ,McKernan PA,Burns NJ 3rd,North JA,Murray BK,Robins RK

更新日期：1984-10-01 00:00:00

abstract：:The in vitro activity of LY 146032, a cyclic lipopeptide antibiotic belonging to the class of agents designated A21978C, was compared with those of vancomycin, cefpirome, cefotaxime, and clindamycin against selected gram-positive bacteria. The new drug inhibited all staphylococcal isolates, including methicillin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Eliopoulos GM,Willey S,Reiszner E,Spitzer PG,Caputo G,Moellering RC Jr

更新日期：1986-10-01 00:00:00

abstract：:Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic transformation. Due to previous work linking CSP to stress phenotypes, we set up an in vivo sepsis model to assay its effect on viru...

journal_title：Antimicrobial agents and chemotherapy

authors： Oggioni MR,Iannelli F,Ricci S,Chiavolini D,Parigi R,Trappetti C,Claverys JP,Pozzi G

更新日期：2004-12-01 00:00:00

abstract：:Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches in...

journal_title：Antimicrobial agents and chemotherapy

authors： Townsend EM,Sherry L,Kean R,Hansom D,Mackay WG,Williams C,Butcher J,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model describing developme...

journal_title：Antimicrobial agents and chemotherapy

authors： Bijleveld YA,de Haan TR,van der Lee JH,Groenendaal F,Dijk PH,van Heijst A,de Jonge RCJ,Dijkman KP,van Straaten HLM,Rijken M,Zonnenberg IA,Cools F,Zecic A,Nuytemans DHGM,van Kaam AH,Mathôt RAA,PharmaCool Study Group.

更新日期：2018-03-27 00:00:00

abstract：:In a previous study we have shown that cultured epithelial cell lines can be used to measure the transepithelial passage of antimicrobial agents across the intestine and to obtain information on the mechanisms of transport utilized and predict the bioavailability of the antimicrobial agents after oral administration. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranaldi G,Islam K,Sambuy Y

更新日期：1994-06-01 00:00:00

abstract：:We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

更新日期：2005-08-01 00:00:00

abstract：:Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlstrom CA,Ramey AM,Woksepp H,Bonnedahl J

更新日期：2019-07-25 00:00:00

abstract：:Because of the widespread occurrence of resistance to sulfonamides among Enterobacteriaceae, some researchers have suggested using trimethoprim (TMP) alone instead of the combination sulfamethoxazole-trimethoprim (SMX-TMP) in treating infections with TMP-susceptible organisms. To answer whether SMX-TMP suppresses the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Guerrant RL,Wood SJ,Krongaard L,Reid RA,Hodge RH

更新日期：1981-01-01 00:00:00

abstract：:The effect of protein binding on drug penetration into blister fluid was evaluated by using cefonicid, ceftizoxime, and cefotaxime. Drug concentrations in a chamber with a high surface area/volume ratio (i.e., paper disk) follow changes in serum more closely than do those in a chamber with a low surface area/volume ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Quintiliani R,Nightingale CH,Dudley MN

更新日期：1988-01-01 00:00:00

abstract：:The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

更新日期：1989-08-01 00:00:00

abstract：:In most experiments when aminoglycoside antibiotic (AG) tissue levels are measured, the AG is extracted into buffered media. The data from this study reveal that buffer extraction results in only partial recovery of AG from tissues and that total recovery can be obtained after NaOH or trichloroacetic acid treatment. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Fox KE

更新日期：1989-04-01 00:00:00

abstract：:Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Parikh S,Fehintola F,Huang L,Olson A,Adedeji WA,Darin KM,Morse GD,Murphy RL,Taiwo BO,Akinyinka OO,Adewole IF,Aweeka FT,Scarsi KK

更新日期：2015-12-01 00:00:00

abstract：:Moderately penicillin-resistant Neisseria meningitidis was responsible for an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada in 1993. We tested fully susceptible and moderately resistant strains of N. meningitidis against ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, penicillin, and ri...

journal_title：Antimicrobial agents and chemotherapy

authors： Blondeau JM,Yaschuk Y

更新日期：1995-11-01 00:00:00

abstract：:We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Speer A,Shrestha TB,Bossmann SH,Basaraba RJ,Harber GJ,Michalek SM,Niederweis M,Kutsch O,Wolschendorf F

更新日期：2013-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00

abstract：:Southeast Asia (the Thailand-Cambodia border) has been considered the primal epicenter for most antimalarial drug resistance; however, numerous molecular epidemiological studies have successively reported multiple independent origins of sulfadoxine-pyrimethamine (SP) resistance-associated Plasmodium falciparum dhfr (p...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Yan H,Wei G,Han S,Huang Y,Zhang Q,Pan W

更新日期：2014-01-01 00:00:00

abstract：:Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Hallett P,Maxwell A

更新日期：1991-02-01 00:00:00

abstract：:Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepa...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes E,Salio M,Cerundolo V,Medlin J,Murphy S,Dusheiko G,Klenerman P

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally experience rapid reinfection of their new liver graft. Current treatment protocols do not prevent graft reinfection and, in addition, an accelerated disease progression is observed. In the present study, we have evaluated a novel st...

journal_title：Antimicrobial agents and chemotherapy

authors： Meuleman P,Albecka A,Belouzard S,Vercauteren K,Verhoye L,Wychowski C,Leroux-Roels G,Palmer KE,Dubuisson J

更新日期：2011-11-01 00:00:00

abstract：:The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration (IC(50)) against intrace...

journal_title：Antimicrobial agents and chemotherapy

authors： Maes L,Vanden Berghe D,Germonprez N,Quirijnen L,Cos P,De Kimpe N,Van Puyvelde L

更新日期：2004-01-01 00:00:00