Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.

Abstract:

:We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.

authors

Speer A,Shrestha TB,Bossmann SH,Basaraba RJ,Harber GJ,Michalek SM,Niederweis M,Kutsch O,Wolschendorf F

doi

10.1128/AAC.01781-12

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

1089-91

issue

2

eissn

0066-4804

issn

1098-6596

pii

AAC.01781-12

journal_volume

57

pub_type

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