Efficacy of itraconazole solution in a rabbit model of invasive aspergillosis.

abstract：:A clinical trial was designed to evaluate the efficacy and safety of cefotaxime, a new semisynthetic, broad-spectrum cephalosporin, in the therapy of community-and hospital-acquired pneumonias. Thirty-nine males (mean age, 65 years) were treated for 41 episodes of pneumonia. Only five patient did not have a serious un...

journal_title：Antimicrobial agents and chemotherapy

authors： Schleupner CJ,Engle JC

更新日期：1982-02-01 00:00:00

abstract：:Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic transformation. Due to previous work linking CSP to stress phenotypes, we set up an in vivo sepsis model to assay its effect on viru...

journal_title：Antimicrobial agents and chemotherapy

authors： Oggioni MR,Iannelli F,Ricci S,Chiavolini D,Parigi R,Trappetti C,Claverys JP,Pozzi G

更新日期：2004-12-01 00:00:00

abstract：:The activity of two cefoperazone-sulbactam combinations against anaerobic bacteria was tested and compared both with that of cefoperazone alone and with that of other commonly used antimicrobial agents. Imipenem was the most active of the tested agents, followed by chloramphenicol, metronidazole, and cefoperazone-sulb...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Finegold SM

更新日期：1988-03-01 00:00:00

abstract：:We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant)...

journal_title：Antimicrobial agents and chemotherapy

authors： Donà V,Bernasconi OJ,Pires J,Collaud A,Overesch G,Ramette A,Perreten V,Endimiani A

更新日期：2017-10-24 00:00:00

abstract：:The MICs of echinocandins against Candida isolates with fks mutations are higher than those for wild-type (WT) isolates. However, the MIC ranges for susceptible and mutant populations overlap or are poorly separated. It was recently reported that a greater separation could be achieved in the presence of serum. To more...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Rodriguez-Tudela JL,Park S,Garcia-Effron G,Delmas G,Cuenca-Estrella M,Gomez-Lopez A,Perlin DS

更新日期：2011-04-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

更新日期：2008-06-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00

abstract：:Among yeast strains of human origin belonging to the genera Candida, Cryptococcus, Torulopsis, and Rhodotorula which were examined for killer and sensitive characteristics with killer and sensitive strains of Cryptococcus, Hansenula, Kluyveromyces, Pichia, Saccharomyces, and Torulopsis as screening organisms, a high i...

journal_title：Antimicrobial agents and chemotherapy

authors： Middelbeek EJ,Hermans JM,Stumm C,Muytjens HL

更新日期：1980-03-01 00:00:00

abstract：:The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglyce...

journal_title：Antimicrobial agents and chemotherapy

authors： Javor GT

更新日期：1983-12-01 00:00:00

abstract：:The in vitro potency and in vivo efficacy of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae were investigated by pharmacokinetic studies with M. pneumoniae-infected hamsters. By using fluoroquinolones, macrolides, and tetracyclines as references, Q-35 was found to possess the greatest mycoplasmacidal activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gohara Y,Arai S,Akashi A,Kuwano K,Tseng CC,Matsubara S,Matumoto M,Furudera T

更新日期：1993-09-01 00:00:00

abstract：:The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Karachalios GN

更新日期：1985-11-01 00:00:00

abstract：:Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Ozasa DC,Mordenti J

更新日期：1985-07-01 00:00:00

abstract：:Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Adjei GO,Kristensen K,Goka BQ,Hoegberg LC,Alifrangis M,Rodrigues OP,Kurtzhals JA

更新日期：2008-12-01 00:00:00

abstract：:Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazarev VN,Polina NF,Shkarupeta MM,Kostrjukova ES,Vassilevski AA,Kozlov SA,Grishin EV,Govorun VM

更新日期：2011-11-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00

abstract：:We tested the activities of anidulafungin and other antifungal agents against clinical isolates of different fungal species. For Candida species, high sessile MIC₉₀s (SMIC₉₀s) were obtained for fluconazole, voriconazole, and amphotericin B, whereas the anidulafungin SMIC₉₀s were very low, as were those for caspofungin...

journal_title：Antimicrobial agents and chemotherapy

authors： Fiori B,Posteraro B,Torelli R,Tumbarello M,Perlin DS,Fadda G,Sanguinetti M

更新日期：2011-06-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen associated with nosocomial pneumonia and is an increasing threat for severe community-acquired pneumonia. We have now investigated the role of interleukin-12 (IL-12) in protective immunity against lung infection with MRSA. The importance of IL-12 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen QT,Furuya Y,Roberts S,Metzger DW

更新日期：2015-10-01 00:00:00

abstract：:A broad-spectrum vaginal microbicide must be effective against a variety of sexually transmitted disease pathogens and be minimally toxic to the cell types found within the vaginal epithelium, including vaginal keratinocytes. We assessed the sensitivity of primary human vaginal keratinocytes to potential topical vagin...

journal_title：Antimicrobial agents and chemotherapy

authors： Krebs FC,Miller SR,Catalone BJ,Welsh PA,Malamud D,Howett MK,Wigdahl B

更新日期：2000-07-01 00:00:00

abstract：:The penamaldic derivatives of amoxicillin, ampicillin, and penicillins G and V, stabilized with Zn(2+), were obtained from a methanolic medium. The enzymatic kinetic results show that the these derivatives elicit reversible inhibition of the enzyme metallo-beta-lactamase from Bacillus cereus, with inhibition constant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Navarro PG,Osso BQ,Ortiz RG,Martínez De Las Parras PJ,Martínez Puentedura MI,Cabeza González MC

更新日期：2004-03-01 00:00:00

abstract：:Susceptibility tests using 7 antimicrobial agents (carbenicillin, chloramphenicol, clindamycin, penicillin, cephalothin, metronidazole, and tetracycline) were run against 35 anaerobes including Bacteroides fragilis (17), other gram-negative bacilli (7), clostridia (5), peptococci (4), and eubacteria (2). Results in tr...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosenblatt JE,Murray PR,Sonnenwirth AC,Joyce JL

更新日期：1979-03-01 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:Echinocandins are important in the prevention and treatment of invasive candidiasis but limited by current dosing regimens that include daily intravenous administration. The novel echinocandin CD101 has a prolonged half-life of approximately 130 h in humans, making it possible to design once-weekly dosing strategies. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,VanScoy B,Ambrose PG,Andes DR

更新日期：2018-01-25 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:Leukocyte chemotaxis was inhibited 9.6% compared with control in the presence of 10 mug of gentamicin per ml and 10.5% when exposed to 20 mug of amikacin per ml. However, cells incubated with an injectable form of gentamicin, containing preservatives, were inhibited an additional 25.8% relative to cells incubated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodhart GL

更新日期：1977-10-01 00:00:00

abstract：:A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolon...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto M,Matsumura Y,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2018-07-27 00:00:00

abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Westenfelder SR,Madsen PO

更新日期：1973-04-01 00:00:00

abstract：:Amphotericin B lipid complex for injection (ABLC) is a suspension of amphotericin B complexed with the lipids L-alpha-dimyristoylphosphatidylcholine (DMPC) and L-alpha-dimyristoylphosphatidylglycerol. ABLC is less toxic than amphotericin B deoxycholate (AmB-d), while it maintains the antifungal activity of AmB-d. Acti...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson CE,Perkins WR,Roberts P,Ahmad I,Stevens R,Stevens DA,Janoff AS

更新日期：1998-04-01 00:00:00

abstract：:The aim of the study was to evaluate the penetration of ciprofloxacin into bronchial secretions from mechanically ventilated patients with nosocomial bronchopneumonia. For this purpose, in each patient studied, simultaneous serial blood and bronchial secretion samples were obtained over a 12-h period on days 2 and 4. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saux P,Martin C,Mallet MN,Papazian L,Bruguerolle B,De Micco P,Gouin F

更新日期：1994-04-01 00:00:00