Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects.

abstract：:Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao V,Lambert T,Nhu DQ,Loan HK,Hoang NK,Arlet G,Courvalin P

更新日期：2002-12-01 00:00:00

abstract：:Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam, is approved for treating complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. To determine doses ...

journal_title：Antimicrobial agents and chemotherapy

authors： Larson KB,Patel YT,Willavize S,Bradley JS,Rhee EG,Caro L,Rizk ML

更新日期：2019-05-24 00:00:00

abstract：:Nonreplicating bacteria are known to be (or at least commonly thought to be) refractory to antibiotics to which they are genetically susceptible. Here, we explore the sensitivity to killing by bactericidal antibiotics of three classes of nonreplicating populations of planktonic bacteria: (i) stationary phase, when the...

journal_title：Antimicrobial agents and chemotherapy

authors： McCall IC,Shah N,Govindan A,Baquero F,Levin BR

更新日期：2019-06-24 00:00:00

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00

abstract：:The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found to have a double-ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Greenier JL,Marthas ML,Otsyula MG,Tarara RP,Miller CJ,Pedersen NC

更新日期：1997-02-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:Pseudomonas aeruginosa strains that produce metallo-beta-lactamases (MBLs) are becoming increasingly prevalent. We evaluated the epidemiological and microbiological characteristics of monomicrobial bloodstream infections caused by MBL-producing P. aeruginosa isolates, as well as the clinical outcomes in patients with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marra AR,Pereira CA,Gales AC,Menezes LC,Cal RG,de Souza JM,Edmond MB,Faro C,Wey SB

更新日期：2006-01-01 00:00:00

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Felici A,Perilli M,Segatore B,Franceschini N,Setacci D,Oratore A,Stefani S,Galleni M,Amicosante G

更新日期：1995-06-01 00:00:00

abstract：:The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when administered parenterally or b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline C,Harden E,Keith K,Rodriguez N,Beadle JR,Hostetler KY

更新日期：2002-04-01 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:A basic, random copolymer of l-ornithine and l-leucine (OL; molar ratios 1:1) was bactericidal to a sensitive (S) strain of Staphylococcus aureus at low concentration. Resistant cells (R) were selected from the culture medium and, after serial transfers to solutions containing increasing amounts of the polymer, grew w...

journal_title：Antimicrobial agents and chemotherapy

authors： Shenfeld A,Flowers HM,Katchalski E

更新日期：1974-02-01 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:The in vitro and in vivo activity of FR-31564 [sodium hydrogen 3-(N-hydroxyformamido)propylphosphate] against gram-positive and -negative aerobic and anaerobic bacteria was investigated and compared with that of fosfomycin, cephalexin, carbenicillin, and trimethoprim-sulfamethoxazole. The in vitro activity of FR-31564...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Kamimura T

更新日期：1981-06-01 00:00:00

abstract：:Staphylococcus aureus is a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased resistance in a variety of pathogens, including S. aureus It is thus imperative to explore alter...

journal_title：Antimicrobial agents and chemotherapy

authors： van Staden Adu P,Heunis T,Smith C,Deane S,Dicks LM

更新日期：2016-06-20 00:00:00

abstract：:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen Pseudomonas aeruginosa in the presence of the glycoprotein mucin, which is found in high abundance at mucosal surfaces, especially those of the lungs of cystic fibrosis and bronchiectasis patients. Here, we investigated the ada...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun E,Gill EE,Falsafi R,Yeung A,Liu S,Hancock REW

更新日期：2018-08-27 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its union to the mitochondrial bc1 complex, preventing the ubiquinone-8,9 (UQ) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesis in Plasmodium falciparum and adopted proof-of-c...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdaguer IB,Crispim M,Zafra CA,Sussmann RAC,Buriticá NL,Melo HR,Azevedo MF,Almeida FG,Kimura EA,Katzin AM

更新日期：2021-01-25 00:00:00

abstract：:The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grewal J,Manavathu EK,Taylor DE

更新日期：1993-12-01 00:00:00

abstract：:Fragments (414 bp) of the gene-encoding ribosomal protein L16 from Enterococcus faecium and Enterococcus faecalis that were resistant and susceptible to the oligosaccharide antibiotics avilamycin and evernimicin (SCH 27899) were sequenced and compared. The susceptible E. faecalis and E. faecium isolates had sequences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarestrup FM,Jensen LB

更新日期：2000-12-01 00:00:00

abstract：:Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

更新日期：2009-09-01 00:00:00

abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

journal_title：Antimicrobial agents and chemotherapy

authors： Everett MJ,Chopra I,Bennett PM

更新日期：1990-12-01 00:00:00

abstract：:One hundred clinical isolates of methicillin-resistant (Metr) Staphylococcus aureus from five different geographical origins were tested for their susceptibility to 12 non-beta-lactam antibiotics by the broth microdilution technique recommended by the National Committee for Clinical Laboratory Standards. Coumermycin a...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Janney A,Sanders CV

更新日期：1985-11-01 00:00:00

abstract：:The present study confirms that CBA/J mice are susceptible to several clinical isolates of Streptococcus pneumoniae, including four of five penicillin-susceptible and all five penicillin-resistant strains tested, thus providing the first noncompromised animal model for penicillin-resistant S. pneumoniae pneumonia. In ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tateda K,Takashima K,Miyazaki H,Matsumoto T,Hatori T,Yamaguchi K

更新日期：1996-06-01 00:00:00

abstract：:Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

journal_title：Antimicrobial agents and chemotherapy

authors： Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

更新日期：2019-10-22 00:00:00

abstract：:Lupeol, which shows in vitro inhibitory activity against Plasmodium falciparum 3D7 strain with a 50% inhibitory concentration (IC50) of 27.7 +/- 0.5 microM, was shown to cause a transformation of the human erythrocyte shape toward that of stomatocytes. Good correlation between the IC50 value and the membrane curvature...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziegler HL,Staerk D,Christensen J,Hviid L,Hägerstrand H,Jaroszewski JW

更新日期：2002-05-01 00:00:00

abstract：:The effects of ceftizoxime and gentamicin alone and in combination were determined against 100 Pseudomonas aeruginosa strains. Concentrations of 32 micrograms of ceftizoxime and 8 micrograms of gentamicin per ml inhibited 22 and 43% of the strains, respectively. At concentrations of ceftizoxime and gentamicin that are...

journal_title：Antimicrobial agents and chemotherapy

authors： King JW,Penn RL

更新日期：1984-06-01 00:00:00

abstract：:A fosmid library from genomic DNA of Streptomyces viridochromogenes DSM 40736 was constructed and screened for the presence of genes known to be involved in the biosynthesis of phosphinothricin tripeptide (PTT). Eight positives were identified, one of which was able to confer PTT biosynthetic capability upon Streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Blodgett JA,Zhang JK,Metcalf WW

更新日期：2005-01-01 00:00:00