Antagonism between aminoglycosides and beta-lactams in a methicillin-resistant Staphylococcus aureus isolate involves induction of an aminoglycoside-modifying enzyme.

abstract：:A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable ...

journal_title：Antimicrobial agents and chemotherapy

authors： Partridge SR,Thomas LC,Ginn AN,Wiklendt AM,Kyme P,Iredell JR

更新日期：2011-06-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa, PAe191, was found to be highly resistant to all anti-Pseudomonas beta-lactam antibiotics (except imipenem) and resistant also to aminoglycosides. It produced a beta-lactamase (with an apparent pI of 7.6) which was not inhibited by clavulanic acid. Cloning and characterizat...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugnier P,Casin I,Bouthors AT,Collatz E

更新日期：1998-12-01 00:00:00

abstract：:Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of rifampin on efavirenz pharmacokinetics. Subjects were randomized to re...

journal_title：Antimicrobial agents and chemotherapy

authors： Kwara A,Tashima KT,Dumond JB,Poethke P,Kurpewski J,Kashuba AD,Court MH,Greenblatt DJ

更新日期：2011-07-01 00:00:00

abstract：:The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when administered orally every 12 h for 7 days at doses of 100, 200, 300, 400, 600, and 800 mg. Steady-state maximum and minimum...

journal_title：Antimicrobial agents and chemotherapy

authors： Granneman GR,Carpentier P,Morrison PJ,Pernet AG

更新日期：1992-02-01 00:00:00

abstract：:Teicoplanin is an investigational glycopeptide antibiotic that is structurally and microbiologically similar to vancomycin. Since teicoplanin possesses a very long elimination half-life, the manufacturer suggests that the drug be administered every 12 h for the first day of therapy and once daily thereafter. We studie...

journal_title：Antimicrobial agents and chemotherapy

authors： Outman WR,Nightingale CH,Sweeney KR,Quintiliani R

更新日期：1990-11-01 00:00:00

abstract：:The antibacterial drug nalidixic acid (Nal) can suppress the growth of Candida albicans at levels of the drug normally found in urine. Growth suppression increases as drug levels are increased, and Nal also causes a similar proportional inhibition of the synthesis of all cellular macromolecules. However, growth temper...

journal_title：Antimicrobial agents and chemotherapy

authors： Sobieski RJ,Brewer AR

更新日期：1976-03-01 00:00:00

abstract：:The potential for resistance development in Streptococcus pneumoniae secondary to exposure to gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin at various levels was examined at high inoculum (10(8.5) to 10(9) log10 CFU/ml) over 96 h in an in vitro pharmacodynamic (PD) model using two fluoroquinolone-suscepti...

journal_title：Antimicrobial agents and chemotherapy

authors： LaPlante KL,Rybak MJ,Tsuji B,Lodise TP,Kaatz GW

更新日期：2007-04-01 00:00:00

abstract：:The mechanism(s) of daptomycin (DAP) resistance (DAPr) is incompletely defined. Thickened cell walls (CWs) acting as either a mechanical barrier or an affinity trap for DAP have been purported to be a major contributor to the DAPr phenotype. To this end, we studied an isogenic set of methicillin-resistant Staphylococc...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang SJ,Nast CC,Mishra NN,Yeaman MR,Fey PD,Bayer AS

更新日期：2010-08-01 00:00:00

abstract：:Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

journal_title：Antimicrobial agents and chemotherapy

authors： Azimi PH,Dunphy MG

更新日期：1989-09-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00

abstract：:NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phe...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong-Bolduc QC,Strahilevitz J,Hooper DC

更新日期：2006-03-01 00:00:00

abstract：:Macrolide antibiotics like erythromycin can prevent the formation of the 50S ribosomal subunit in growing bacterial cells, in addition to their inhibitory effect on translation. The significance of this novel finding has been further investigated. The 50% inhibitory doses of erythromycin for the inhibition of translat...

journal_title：Antimicrobial agents and chemotherapy

authors： Champney WS,Burdine R

更新日期：1996-05-01 00:00:00

abstract：:Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately posttherapy, pretreatment signs and symptoms resolved among 91% of the 33 evaluable patients. At 6 months, all 28 of the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Dattwyler RJ,Grunwaldt E,Luft BJ

更新日期：1996-02-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Cuchural GJ Jr,Jacobus NV,Gorbach SL,Aldridge K,Cleary T,Finegold SM,Hill G,Iannini P,O'Keefe JP

更新日期：1985-11-01 00:00:00

abstract：:The biological availability of cefoxitin administered rectally in the form of suppositories was examined in six human subjects by a cross-over design. Four different suppository systems containing adjuvants expected to enhance the absorption of the drug were studied. The presence of sodium salicylate and a nonionic su...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis SS,Burnham WR,Wilson P,O'Brien J

更新日期：1985-08-01 00:00:00

abstract：:Tiacumicins B and C are members of a novel group of 18-membered macrolide antibiotics with in vitro activity against Clostridium difficile. The MICs against 15 strains of C. difficile were 0.12 to 0.25 microgram/ml for tiacumicin B, 0.25 to 1 microgram/ml for tiacumicin C, and 0.5 to 1 microgram/ml for vancomycin. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Swanson RN,Hardy DJ,Shipkowitz NL,Hanson CW,Ramer NC,Fernandes PB,Clement JJ

更新日期：1991-06-01 00:00:00

abstract：:We undertook a prospective, randomized comparison of oral ciprofloxacin with standard parenteral therapies for the treatment of biopsy-proven osteomyelitis caused by susceptible organisms. Following surgical debridement, the ciprofloxacin patients received 750 mg twice a day, and the other patients received a broad-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez GG

更新日期：1990-01-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:We have studied the aminoglycoside resistance gene, which confers high levels of resistance to both amikacin and gentamicin, that is carried by plasmid pSTI1 in the PER-1 beta-lactamase-producing strain of Salmonella enterica serovar Typhimurium previously isolated in Turkey. This gene, called aac(6')-Ib(11), was foun...

journal_title：Antimicrobial agents and chemotherapy

authors： Casin I,Hanau-Berçot B,Podglajen I,Vahaboglu H,Collatz E

更新日期：2003-02-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:An uncoupler of oxidative phosphorylation, 2,4-dinitrophenol, and an aconitase inhibitor, fluoroacetic acid, both of which are known to lower the cellular ATP pool, protected Escherichia coli cells from the bactericidal actions of gyrase poisons including quinolone antibiotics, nalidixic acid and ciprofloxacin, and th...

journal_title：Antimicrobial agents and chemotherapy

authors： Li TK,Liu LF

更新日期：1998-05-01 00:00:00

abstract：:Mycoplasma hominis was highly susceptible to two new quinolones, with MICs for 90% of isolates tested of 0.004 micrograms/ml for WIN 57273 and 0.063 micrograms/ml for sparfloxacin, which were activities much greater than the 1 microgram/ml found for ofloxacin and tetracycline. Although Ureaplasma urealyticum was less ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Cartwright FD

更新日期：1991-07-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:Active nuclear importation of the human immunodeficiency virus (HIV) type 1 (HIV-1) preintegration complex (PIC) is required for the productive infection of nondividing cells, but it is believed to be dispensable for the infection of proliferating cells, such as activated T lymphocytes. To investigate this question, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Haffar OK,Smithgall MD,Popov S,Ulrich P,Bruce AG,Nadler SG,Cerami A,Bukrinsky MI

更新日期：1998-05-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:The current recommendations for intravenous (i.v.) acyclovir dosing in obese patients suggest using ideal body weight (IBW) rather than total body weight (TBW). To our knowledge, no pharmacokinetic analysis has validated this recommendation. This single-dose pharmacokinetic study was conducted in an inpatient oncology...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Cumpston A,Sweet M,Briggs F,Slain D,Wen S,Craig M,Hamadani M,Petros W

更新日期：2016-01-11 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

journal_title：Antimicrobial agents and chemotherapy

authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

更新日期：2017-10-24 00:00:00