In vitro and in vivo evaluation of tiacumicins B and C against Clostridium difficile.

abstract：:The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Padilla E,Alonso D,Doménech-Sánchez A,Gomez C,Pérez JL,Albertí S,Borrell N

更新日期：2006-06-01 00:00:00

abstract：:An international interlaboratory quality control program for measurement of antiretroviral drugs was initiated. The first round was confined to protease inhibitors and showed large variability in the performance of participating laboratories. The results demonstrate the need for and utility of an ongoing quality contr...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarnoutse RE,Verweij-van Wissen CP,van Ewijk-Beneken Kolmer EW,Wuis EW,Koopmans PP,Hekster YA,Burger DM

更新日期：2002-03-01 00:00:00

abstract：:The aim of the present study was to characterize the pharmacokinetic-pharmacodynamic relationship of GV143253A, a novel trinem anti-methicillin-resistant Staphylococcus aureus (MRSA) agent active against gram-positive cocci, including multidrug-resistant clinical isolates. An in vitro pharmacodynamic study with methic...

journal_title：Antimicrobial agents and chemotherapy

authors： Ferrari L,Iavarone L,Braggio S,Di Modugno E

更新日期：2003-02-01 00:00:00

abstract：:The in vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of the MICs and minimum bactericidal concentrations (MBCs), timed killing, single-step and multistep mutation rates, the erythromycin indu...

journal_title：Antimicrobial agents and chemotherapy

authors： Woosley LN,Castanheira M,Jones RN

更新日期：2010-05-01 00:00:00

abstract：:TEM-24 remains one of the most widespread TEM-type extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae. To analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative TEM-24 producers from Belgium, France, Portugal, and Spain (1...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais A,Baquero F,Machado E,Cantón R,Peixe L,Coque TM

更新日期：2010-02-01 00:00:00

abstract：:The inhibition of Saccharomyces cerevisiae growth by amphotericin B and rifampin was studied. Rifampin alone had no effect on growth or macromolecular syntheses. Lethal amounts of amphotericin B produced a late inhibition of ribonucleic acid (RNA) synthesis simultaneous with the arrest of growth and protein synthesis....

journal_title：Antimicrobial agents and chemotherapy

authors： Battaner E,Kumar BV

更新日期：1974-04-01 00:00:00

abstract：:Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

journal_title：Antimicrobial agents and chemotherapy

authors： Azimi PH,Dunphy MG

更新日期：1989-09-01 00:00:00

abstract：:6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses were conducted usin...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu T,Tripathi SK,Feng Q,Lorenz MC,Wright MA,Jacob MR,Mask MM,Baerson SR,Li XC,Clark AM,Agarwal AK

更新日期：2012-06-01 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum beta-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phy...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitout JD,Laupland KB,Church DL,Menard ML,Johnson JR

更新日期：2005-11-01 00:00:00

abstract：:The in vitro activities of two investigational quinolones, sparfloxacin (previously designated AT 4140) and PD 127391, were determined for 30 strains each of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum and compared with those of ciprofloxacin, tetracycline, clindamycin, and erythromycin. Eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Duffy LB,Schmid T,Crabb D,Pate MS,Cassell GH

更新日期：1991-06-01 00:00:00

abstract：:Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Somma S,Merati W,Parenti F

更新日期：1977-03-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak co...

journal_title：Antimicrobial agents and chemotherapy

authors： Pradines B,Tall A,Fusai T,Spiegel A,Hienne R,Rogier C,Trape JF,Le Bras J,Parzy D

更新日期：1999-02-01 00:00:00

abstract：:Two patients (patients A and B) infected with Salmonella typhimurium failed ciprofloxacin therapy, and the posttherapy isolates had reduced susceptibilities to quinolones; 6 of 11 isolates from patient B were also cross-resistant to chemically unrelated agents. No transferable resistance, chloramphenicol-acetylating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Piddock LJ,Griggs DJ,Hall MC,Jin YF

更新日期：1993-04-01 00:00:00

abstract：:Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, poor bioavailability, or drug resistance mechanism developed by the parasite. Thus...

journal_title：Antimicrobial agents and chemotherapy

authors： Spalenka J,Escotte-Binet S,Bakiri A,Hubert J,Renault JH,Velard F,Duchateau S,Aubert D,Huguenin A,Villena I

更新日期：2018-01-25 00:00:00

abstract：:This analysis of nearly 10,000 hospital-associated urinary tract infection (UTI) episodes due to Escherichia coli showed that fluoroquinolone and third-generation-cephalosporin resistance rates were 34.5% and 8.6%, respectively; the rate of concurrent resistance to both agents was 7.3%. Fluoroquinolone resistance rate...

journal_title：Antimicrobial agents and chemotherapy

authors： Bidell MR,Palchak M,Mohr J,Lodise TP

更新日期：2016-04-22 00:00:00

abstract：:The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman D,Bryskier A,Lowther J,Appelbaum PC

更新日期：2006-11-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii is a major source of nosocomial infections worldwide and is mainly associated with the acquisition of OXA-type carbapenemases and, to a lesser extent, metallo-β-lactamases (MBLs). In this study, 82 nonepidemiologically related Acinetobacter strains carrying different types ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Zboromyrska Y,Mosqueda N,Morosini MI,García-Fernández S,Roca I,Cantón R,Marco F,Vila J

更新日期：2014-12-01 00:00:00

abstract：:Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation. Mo...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Tasneen R,Chaira T,Stec J,Onajole OK,Yang TJ,Cooper CB,Mdluli K,Converse PJ,Nuermberger EL,Raj VS,Kozikowski A,Bishai WR

更新日期：2019-06-24 00:00:00

abstract：:Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement therapies are not well ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hafner V,Czock D,Burhenne J,Riedel KD,Bommer J,Mikus G,Machleidt C,Weinreich T,Haefeli WE

更新日期：2010-06-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

更新日期：2013-11-01 00:00:00

abstract：:The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Novotna GB,Kwun MJ,Hong HJ

更新日期：2015-12-28 00:00:00

abstract：:Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003...

journal_title：Antimicrobial agents and chemotherapy

authors： Balwan A,Nicolau DP,Wungwattana M,Zuckerman JB,Waters V

更新日期：2015-12-31 00:00:00

abstract：:The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model to determine their potential utility as drugs against human immunodeficiency virus. Drugs were administered by intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupia RH,Ferencz N,Lertora JJ,Aggarwal SK,George WJ,Agrawal KC

更新日期：1993-04-01 00:00:00

abstract：:We conducted a randomized controlled trial of orally administered amifloxacin versus trimethoprimsulfamethoxazole (TMP-SMX) as treatments of acute uncomplicated urinary tract infection in women. Amifloxacin at a dosage of 200 mg twice a day appeared as safe and effective as TMP-SMX, but amifloxacin at 400 mg twice a d...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyko EJ,Iravani A,Silverman MH,Schelling DJ,Wright RA

更新日期：1990-04-01 00:00:00

abstract：:The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, qui...

journal_title：Antimicrobial agents and chemotherapy

authors： Allison RG,Hahn FE

更新日期：1977-02-01 00:00:00

abstract：:Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P...

journal_title：Antimicrobial agents and chemotherapy

authors： Cascio A,Di Liberto C,D'Angelo M,Iaria C,Scarlata F,Titone L,Campisi G

更新日期：2004-07-01 00:00:00