Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin.

abstract：:New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Gevers T,Van Den Berg J,Andries K

更新日期：2008-10-01 00:00:00

abstract：:We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M. hyorhinis contamination. In the present work, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fassi Fehri L,Wróblewski H,Blanchard A

更新日期：2007-02-01 00:00:00

abstract：:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Deveikis A,Schauf V,Mizen M,Riff L

更新日期：1977-05-01 00:00:00

abstract：:The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was examined by using specific inhibitors. Buthionine sulfoximine (BSO) significantly reversed the resistance to trivalent Sb (Sb(III)) of promastigotes of experimentally derived Sb-resistant lines, suppor...

journal_title：Antimicrobial agents and chemotherapy

authors： Goyeneche-Patino DA,Valderrama L,Walker J,Saravia NG

更新日期：2008-12-01 00:00:00

abstract：:The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycli...

journal_title：Antimicrobial agents and chemotherapy

authors： Shipley PL,Olsen RH

更新日期：1974-08-01 00:00:00

abstract：:Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wingard JR,Bender WJ,Saral R,Burns WH

更新日期：1981-08-01 00:00:00

abstract：:Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang G,Kamalakaran S,Dhand A,Huang W,Ojaimi C,Zhuge J,Yee LL,Mayigowda P,Surendraiah PK,Dimitrova N,Fallon JT

更新日期：2014-08-01 00:00:00

abstract：:Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin serotype A. This fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,McKenzie R,Fuchs EJ,Jurao RA,An AT,Ahene A,Tomic M,Hendrix CW,Zenilman JM

更新日期：2014-09-01 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00

abstract：:Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vignaroli C,Biavasco F,Varaldo PE

更新日期：2006-07-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Resistance to 5-fluorocytosine was studied in 137 independent Candida albicans clinical isolates. Seventy-eight isolates (57%) were susceptible; 51 isolates (37%) were partially resistant; 8 isolates (6%) were highly resistant. All partially resistant isolates gave rise to variants which were highly resistant. Some su...

journal_title：Antimicrobial agents and chemotherapy

authors： Defever KS,Whelan WL,Rogers AL,Beneke ES,Veselenak JM,Soll DR

更新日期：1982-11-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were studied in 10 cystic fibrosis patients, ranging in age from 11 to 28 years. The patients received a 9- to 23-day course of 350 mg of azlocillin per kg in four or six divided daily doses in combination with am aminoglycoside. Blood and urine samples were collected at specified ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Bosso JA,Saxon BA,Herbst JJ,Matsen JM

更新日期：1984-05-01 00:00:00

abstract：:We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a short hairpin RNA (shRNA). To design small interfering RNAs (siRNAs) targeting this site, we evaluated the effects of siRNAs with different lengths on HIV-1 production. The potency and efficacy of these siRNAs...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarborough RJ,Adams KL,Daher A,Gatignol A

更新日期：2015-09-01 00:00:00

abstract：:A rapid-flow cytofluorometric susceptibility test for in vitro amphotericin B testing of yeasts was evaluated and compared to the National Committee for Clinical Laboratory Standards (NCCLS) M27-T reference broth macrodilution method. The flow cytofluorometric method is based on the detection of decreased green fluore...

journal_title：Antimicrobial agents and chemotherapy

authors： Peyron F,Favel A,Guiraud-Dauriac H,El Mzibri M,Chastin C,Dumenil G,Regli P

更新日期：1997-07-01 00:00:00

abstract：:The Chinese traditional medicine mao-bushi-saishin-to (MBST), which has anti-inflammatory effects and has been used to treat the common cold and nasal allergy in Japan, was examined for its effects on the therapeutic activity of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium avium complex (MAC) infe...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu T,Tomioka H,Sato K,Sano C,Akaki T,Dekio S,Yamada Y,Kamei T,Shibata H,Higashi N

更新日期：1999-03-01 00:00:00

abstract：:Protozoan parasites of the Leishmania donovani complex are the causative agents of visceral leishmaniasis (VL), the most severe form of leishmaniasis, with high rates of mortality if left untreated. Leishmania parasites are transmitted to humans through the bite of infected female sandflies (Diptera: Phlebotominae), a...

journal_title：Antimicrobial agents and chemotherapy

authors： Vacchina P,Norris-Mullins B,Abengózar MA,Viamontes CG,Sarro J,Stephens MT,Pfrender ME,Rivas L,Morales MA

更新日期：2016-06-20 00:00:00

abstract：:The yeast Candida albicans is an opportunistic human fungal pathogen and the cause of superficial and systemic infections in immunocompromised patients. The classes of antifungal agents most commonly used to treat Candida infections are the azoles, polyenes, and echinocandins. In the present study, we identified chang...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoehamer CF,Cummings ED,Hilliard GM,Rogers PD

更新日期：2010-05-01 00:00:00

abstract：:The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between th...

journal_title：Antimicrobial agents and chemotherapy

authors： Salfinger M,Heifets LB

更新日期：1988-07-01 00:00:00

abstract：:Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with Taenia solium cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rates in NCC. Racemic a...

journal_title：Antimicrobial agents and chemotherapy

authors： Paredes A,de Campos Lourenço T,Marzal M,Rivera A,Dorny P,Mahanty S,Guerra-Giraldez C,García HH,Nash TE,Cass QB,Cysticercosis Working Group in Peru.

更新日期：2013-02-01 00:00:00

abstract：:The pharmacokinetics of oral and intravenous ofloxacin (7.5 mg.kg of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethell DB,Day NP,Dung NM,McMullin C,Loan HT,Tam DT,Minh LT,Linh NT,Dung NQ,Vinh H,MacGowan AP,White LO,White NJ

更新日期：1996-09-01 00:00:00

abstract：:MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KR...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Saito H,Fujii K,Sato K,Hidaka T

更新日期：1993-01-01 00:00:00

abstract：:The susceptibilities of a range of gram-positive and gram-negative microbial pathogens to clofazimine and its analog B669 (0.1 to 32 micrograms/ml), as well as the effects of these agents on membrane phospholipid metabolism in Staphylococcus aureus and Escherichia coli, have been investigated in vitro. Gram-positive b...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rensburg CE,Jooné GK,O'Sullivan JF,Anderson R

更新日期：1992-12-01 00:00:00

abstract：:R plasmids from chloramphenicol-resistant salmonella from Ontario are shown to belong to the H(2) incompatibility subgroup and to mediate a broad-spectrum, phage inhibition function. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Grant RB

更新日期：1976-10-01 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired infectious diarrhea. LFF571 is a novel inhibitor of the prokaryotic translation elongation factor Tu and is active against a range of bacterial species, including C. difficile. This first-in-human study investigated the safety and pharmacokinetics of sing...

journal_title：Antimicrobial agents and chemotherapy

authors： Ting LS,Praestgaard J,Grunenberg N,Yang JC,Leeds JA,Pertel P

更新日期：2012-11-01 00:00:00

abstract：:The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

更新日期：2014-01-01 00:00:00

abstract：:Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

更新日期：2014-09-01 00:00:00

abstract：:Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (defA) is not. Actin...

journal_title：Antimicrobial agents and chemotherapy

authors： Margolis P,Hackbarth C,Lopez S,Maniar M,Wang W,Yuan Z,White R,Trias J

更新日期：2001-09-01 00:00:00

abstract：:When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep, incorporating an as...

journal_title：Antimicrobial agents and chemotherapy

authors： Holt JD,Cameron D,Dias N,Holding J,Muntendam A,Oostebring F,Dreier P,Rohan L,Nuttall J

更新日期：2015-07-01 00:00:00

abstract：:In 2016, we identified a new class A carbapenemase, VCC-1, in a nontoxigenic Vibrio cholerae strain that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1-producing V. cholerae isolates were recovered along the German coastline. These isolates a...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangat CS,Vadlamani G,Holicek V,Chu M,Larmour VLC,Vocadlo DJ,Mulvey MR,Mark BL

更新日期：2019-03-27 00:00:00