Antimicrobial activities of clofazimine and B669 are mediated by lysophospholipids.

abstract：:Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro;...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes SC,Blanco YC,Justo GZ,Nogueira PA,Rodrigues FL,Goelnitz U,Wunderlich G,Facchini G,Brocchi M,Duran N,Costa FT

更新日期：2009-05-01 00:00:00

abstract：:As drug resistance continues to grow, treatment strategies that turn resistance into a disadvantage for the organism will be increasingly relied upon to treat infections and to lower the rate of multidrug resistance. The majority of work in this area has investigated how resistance evolution toward a single antibiotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez de Evgrafov MC,Faza M,Asimakopoulos K,Sommer MOA

更新日期：2020-12-16 00:00:00

abstract：:The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial n...

journal_title：Antimicrobial agents and chemotherapy

authors： Giacometti A,Cirioni O,Ghiselli R,Orlando F,D'Amato G,Kamysz W,Mocchegiani F,Sisti V,Silvestri C,Łukasiak J,Rocchi M,Saba V,Scalise G

更新日期：2004-08-01 00:00:00

abstract：:Infections caused by carbapenem-resistant KPC-producing Klebsiella pneumoniae are responsible for high rates of mortality and represent a major therapeutic challenge, especially when the isolates are also resistant to colistin. We used the checkerboard method to evaluate the synergistic activity of 10 antibiotic combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tascini C,Tagliaferri E,Giani T,Leonildi A,Flammini S,Casini B,Lewis R,Ferranti S,Rossolini GM,Menichetti F

更新日期：2013-08-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic, and metabolic prope...

journal_title：Antimicrobial agents and chemotherapy

authors： Lake P,DeLeo J,Cerasoli F,Logdberg L,Weetall M,Handley D

更新日期：2004-08-01 00:00:00

abstract：:In this study, the genetic organization of three novel genomic antibiotic resistance islands (AbaRs) in Acinetobacter baumannii isolates belonging to group of European clone II (EC II) comM integrated sequences of 18-, 21-, and 23-kb resistance islands were determined. These resistance islands carry the backbone of Ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Seputiene V,Povilonis J,Suziedeliene E

更新日期：2012-04-01 00:00:00

abstract：:Thirteen derivatives of the Streptococcus pneumoniae TIGR4 strain in which putative drug efflux pumps were genetically inactivated were constructed and characterized. The results indicate that two linked genes encoding the ABC-type transporters SP2073 and SP2075 function together to confer intrinsic resistance to a se...

journal_title：Antimicrobial agents and chemotherapy

authors： Robertson GT,Doyle TB,Lynch AS

更新日期：2005-11-01 00:00:00

abstract：:beta-L-2',3'-Dideoxy-5-fluorocytidine (beta-L-FddC), a novel cytidine analog with an unnatural beta-L sugar configuration, has been demonstrated by our group and others to exhibit highly selective in vitro activity against human immunodeficiency virus types 1 and 2 and hepatitis B virus. This encouraging in vitro anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Martin LT,Cretton-Scott E,Schinazi RF,Zhou XJ,McClure HM,Mathe C,Gosselin G,Imbach JL,Sommadossi JP

更新日期：1999-04-01 00:00:00

abstract：:An estimated 40 million women of reproductive age are infected with one of three species of the waterborne parasite Schistosoma spp. Treatment with praziquantel (PZQ) via mass drug administration (MDA) campaigns is the mainstay of schistosomiasis control for populations living in areas of endemicity. The World Health ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bustinduy AL,Kolamunnage-Dona R,Mirochnick MH,Capparelli EV,Tallo V,Acosta LP,Olveda RM,Friedman JF,Hope WW

更新日期：2020-08-20 00:00:00

abstract：:Antimicrobial efficacy in orthopedic device infections is diminished because of bacterial biofilms which express tolerance to antibiotics. Recently, the use of high doses of levofloxacin with rifampin has been recommended for staphylococcal infections. In the present study, we evaluated the efficacy of levofloxacin at...

journal_title：Antimicrobial agents and chemotherapy

authors： Murillo O,Doménech A,Garcia A,Tubau F,Cabellos C,Gudiol F,Ariza J

更新日期：2006-12-01 00:00:00

abstract：:Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the h...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen LE,Chen PT,Merigan TC

更新日期：1984-10-01 00:00:00

abstract：:A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 50% inhibitory conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Severin A,Chopra R,Krishnamurthy G,Singh G,Hu W,Keeney D,Svenson K,Petersen PJ,Labthavikul P,Shlaes DM,Rasmussen BA,Failli AA,Shumsky JS,Kutterer KM,Gilbert A,Mansour TS

更新日期：2006-02-01 00:00:00

abstract：:The susceptibilities to 20 antimicrobial agents of Bordetella bronchiseptica variants in C mode and degraded phases were compared with those of their parents in X mode. Increases in MICs of 4- to 32-fold were observed for ampicillin, carbenicillin, erythromycin, novobiocin, rifampin, chloramphenicol, nalidixic acid, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa H,Isayama Y,Ohmae K

更新日期：1988-12-01 00:00:00

abstract：:The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by eit...

journal_title：Antimicrobial agents and chemotherapy

authors： Mishin VP,Hayden FG,Gubareva LV

更新日期：2005-11-01 00:00:00

abstract：:Determinants encoding resistance to antibiotics, except penicillin, of 5 of 21 Streptococcus anginosus clinical isolates that we examined transferred by conjugation into Enterococcus faecalis and into 1 to 5 streptococcal recipients at frequencies of 10(-6) to 10(-8) transconjugants per donor. No R plasmids were detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Clermont D,Horaud T

更新日期：1990-09-01 00:00:00

abstract：:The effect of incubation with interferon prior to the stimulation of interferon production (priming) and of sequential treatment with cycloheximide and actinomycin D (superinduction) on the interferon yield from polyinosinic-polycytidylic acid (poly I.poly C)-induced diploid human foreskin cell cultures (FS-3 strain) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Havell EA,Vilcek J

更新日期：1972-12-01 00:00:00

abstract：:Adult diabetic patients admitted to our Diabetes Center from September 1996 to January 1998 for severe, limb-threatening foot infection were consecutively enrolled in a prospective, randomized, controlled clinical study aimed at assessing the safety and efficacy of recombinant human granulocyte colony-stimulating fact...

journal_title：Antimicrobial agents and chemotherapy

authors： de Lalla F,Pellizzer G,Strazzabosco M,Martini Z,Du Jardin G,Lora L,Fabris P,Benedetti P,Erle G

更新日期：2001-04-01 00:00:00

abstract：:Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Sackel SG,Alpert S,Rosner B,McCormack WM,Finland M

更新日期：1977-07-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:Quadruple mutations in the Plasmodium falciparum dihydrofolate reductase (PFDHFR) enzyme give rise to the highest level of pyrimethamine resistance leading to treatment failures. We describe here the presence of these quadruple mutations in a majority of P. falciparum isolates from Car Nicobar (Andaman and Nicobar) Is...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed A,Das MK,Dev V,Saifi MA,Wajihullah,Sharma YD

更新日期：2006-04-01 00:00:00

abstract：:In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of beta-lactamase genes and ftsI gene mutations. For all isolates, the minimal co...

journal_title：Antimicrobial agents and chemotherapy

authors： Kishii K,Chiba N,Morozumi M,Ono A,Ida T,Ubukata K

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to...

journal_title：Antimicrobial agents and chemotherapy

authors： Moyo S,Haldorsen B,Aboud S,Blomberg B,Maselle SY,Sundsfjord A,Langeland N,Samuelsen Ø

更新日期：2015-01-01 00:00:00

abstract：:In a randomized crossover trial, six volunteers received 200- and 400-mg doses of loracarbef (LY 163892), a new oral cephalosporin. Mean +/- standard error of the mean concentrations in serum obtained after 1.5 and 3 h were 13.2 +/- 2.8 and 4.3 +/- 0.7 mg/liter, respectively, after the 400-mg dose and 6.9 +/- 1.0 and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P

更新日期：1992-03-01 00:00:00

abstract：:The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and increased survival of...

journal_title：Antimicrobial agents and chemotherapy

authors： Tong JX,Ang SEL,Tan EHN,Tan KSW

更新日期：2019-03-27 00:00:00

abstract：:There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes in Staphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasive S. aureus (ISA) inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Song KH,Kim M,Kim CJ,Cho JE,Choi YJ,Park JS,Ahn S,Jang HC,Park KH,Jung SI,Yoon N,Kim DM,Hwang JH,Lee CS,Lee JH,Kwak YG,Kim ES,Park SY,Park Y,Lee KS,Lee YS,Kim HB

更新日期：2017-02-23 00:00:00

abstract：:Three mer transposons from the Murray collection of preantibiotic enterobacteria show >99% sequence identity to current isolates. Tn5073 is most closely related to Tn5036 and Tn1696, and Tn5074 is most closely related to Tn5053. Tn5075 is most closely related to Tn21 but lacks integron In2 and is flanked by insertion ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essa AM,Julian DJ,Kidd SP,Brown NL,Hobman JL

更新日期：2003-03-01 00:00:00

abstract：:The pharmacokinetics of cefprozil were determined with 12 volunteers (8 received cefprozil and 4 received a placebo) after oral administration of 500 mg every 12 h over an 8-day period in a randomized, double-blind, placebo-controlled design. Concentrations in serum and urine were measured by high-pressure liquid chro...

journal_title：Antimicrobial agents and chemotherapy

authors： Lode H,Müller C,Borner K,Nord CE,Koeppe P

更新日期：1992-01-01 00:00:00

abstract：:wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lentz CS,Sattler JM,Fendler M,Gottwalt S,Halls VS,Strassel S,Arriens S,Hannam JS,Specht S,Famulok M,Mueller AK,Hoerauf A,Pfarr KM

更新日期：2015-01-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00