In vitro activity of p-hydroxybenzyl penicillin (penicillin X) and five other penicillins against Neisseria gonorrhoeae: comparisons of strains from patients with uncomplicated infections and from women with pelvic inflammatory disease.

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00

abstract：:Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

更新日期：1973-05-01 00:00:00

abstract：:The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergis...

journal_title：Antimicrobial agents and chemotherapy

authors： Michel J,Luboshitzky R,Sacks T

更新日期：1973-09-01 00:00:00

abstract：:A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitzgibbon JE,John JF,Delucia JL,Dubin DT

更新日期：1998-08-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:A series of 11 fluoroquinolone antibacterial agents, including 8 newly synthesized molecules and 3 reference compounds (pefloxacin, ciprofloxacin, and sparfloxacin), were tested for their MICs against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The intracellular accumulation of fluoroquinolone...

journal_title：Antimicrobial agents and chemotherapy

authors： Bazile S,Moreau N,Bouzard D,Essiz M

更新日期：1992-12-01 00:00:00

abstract：:Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison EM,Paterson GK,Holden MT,Morgan FJ,Larsen AR,Petersen A,Leroy S,De Vliegher S,Perreten V,Fox LK,Lam TJ,Sampimon OC,Zadoks RN,Peacock SJ,Parkhill J,Holmes MA

更新日期：2013-03-01 00:00:00

abstract：:Porphyromonas gingivalis is a bacterial pathogen associated with chronic periodontitis that results in destruction of the tooth's supporting tissues. The major virulence determinants of P. gingivalis are its cell surface Arg- and Lys-specific cysteine proteinases, RgpA/B and Kgp. Lactoferrin (LF), an 80-kDa iron-bindi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dashper SG,Pan Y,Veith PD,Chen YY,Toh EC,Liu SW,Cross KJ,Reynolds EC

更新日期：2012-03-01 00:00:00

abstract：:Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

更新日期：2009-08-01 00:00:00

abstract：:Sterol delta22-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol delta22-desaturase activity in a reconstituted system with NADPH-cytochrome P-450 reductase in dila...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamb DC,Maspahy S,Kelly DE,Manning NJ,Geber A,Bennett JE,Kelly SL

更新日期：1999-07-01 00:00:00

abstract：:The in vitro susceptibilities of Actinobacillus actinomycetemcomitans to 14 antimicrobial combinations were studied by using the checkerboard titration technique. The results, expressed as the range of the fractional inhibitory concentration indices, were as follows: for metronidazole or its hydroxymetabolite combined...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavicić MJ,van Winkelhoff AJ,de Graaff J

更新日期：1992-12-01 00:00:00

abstract：:Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent. For many years, the risk of disease reemergence was thought to solely be through deliberate misuse of VARV strains kept in clandestine laboratories. Howev...

journal_title：Antimicrobial agents and chemotherapy

authors： Delaune D,Iseni F

更新日期：2020-03-24 00:00:00

abstract：:Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cef...

journal_title：Antimicrobial agents and chemotherapy

authors： Malik S,Kaminski M,Landman D,Quale J

更新日期：2020-10-20 00:00:00

abstract：:We studied the resistance mechanism and antimicrobial effects of β-lactams on imipenem-resistant Pseudomonas aeruginosa isolates that were susceptible to ceftazidime as detected by time-kill curve methods. Among 215 P. aeruginosa isolates from hospitalized patients in eight hospitals in the Republic of Korea, 18 isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Wi YM,Choi JY,Lee JY,Kang CI,Chung DR,Peck KR,Song JH,Ko KS

更新日期：2017-05-24 00:00:00

abstract：:The in vitro activities of the new triazole, ravuconazole (BMS-207147), were compared to those of fluconazole and itraconazole against 541 clinical isolates of Cryptococcus neoformans. Isolates were obtained from cerebrospinal fluid (396), blood (116), and miscellaneous clinical specimens (29). Overall, ravuconazole (...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamazumi T,Pfaller MA,Messer SA,Houston A,Hollis RJ,Jones RN

更新日期：2000-10-01 00:00:00

abstract：:The ribosome-targeting antimicrobial, spectinomycin (SPC), strongly induced the mexXY genes of the MexXY-OprM multidrug efflux system in Pseudomonas aeruginosa and increased susceptibility to the polycationic antimicrobials polymyxin B and polymyxin E, concomitant with a decrease in expression of the polymyxin resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Poole K,Lau CH,Gilmour C,Hao Y,Lam JS

更新日期：2015-12-01 00:00:00

abstract：:The site of localization of [(3)H]gentamicin within mouse kidney is shown to be the proximal renal tubule by coincidence of the radioactivity, as visualized by autoradiography, and the mucopolysaccharide-rich microvilli characteristic of proximal convoluted tubules, as visualized by histochemical staining. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuhar MJ,Mak LL,Lietman PS

更新日期：1979-01-01 00:00:00

abstract：:Teicoplanin was evaluated in 47 patients with severe infections, including 14 patients with bone infections, 11 patients with soft-tissue infections, 7 patients with endocarditis, 5 patients with pneumonia, 3 patients with septic thrombophlebitis, 3 patients with septicemia of unknown origin, and 4 patients with misce...

journal_title：Antimicrobial agents and chemotherapy

authors： Glupczynski Y,Lagast H,Van der Auwera P,Thys JP,Crokaert F,Yourassowsky E,Meunier-Carpentier F,Klastersky J,Kains JP,Serruys-Schoutens E

更新日期：1986-01-01 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglyce...

journal_title：Antimicrobial agents and chemotherapy

authors： Javor GT

更新日期：1983-12-01 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:para-Aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is still not completely understood. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole-genome sequencing on PAS-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Satta G,Witney AA,Begum N,Ortiz Canseco J,Boa AN,McHugh TD

更新日期：2020-08-20 00:00:00

abstract：:The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alarcón B,González ME,Carrasco L,Méndez-Castrillón PP,García-López MT,de las Heras FG

更新日期：1988-08-01 00:00:00

abstract：:Pseudomonas aeruginosa strains that produce metallo-beta-lactamases (MBLs) are becoming increasingly prevalent. We evaluated the epidemiological and microbiological characteristics of monomicrobial bloodstream infections caused by MBL-producing P. aeruginosa isolates, as well as the clinical outcomes in patients with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marra AR,Pereira CA,Gales AC,Menezes LC,Cal RG,de Souza JM,Edmond MB,Faro C,Wey SB

更新日期：2006-01-01 00:00:00

abstract：:Viomycin-resistant strains isolated from Mycobacterium smegmatis demonstrated pleiotropic resistance to tuberactinomycin-N, capreomycin, streptomycin, and kanamycin as a result of mutational alteration of ribosomes, even though they were selected for resistance to a single antibiotic. The pleiotropic drug resistance o...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamada T,Masuda K,Shoji K,Hori M

更新日期：1974-07-01 00:00:00

abstract：:DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in vitro biofilms. In a murine catheter-associated urinary tract infection model, DS867600...

journal_title：Antimicrobial agents and chemotherapy

authors： Kumar M,Rao M,Purnapatre KP,Barman TK,Joshi V,Kashyap A,Chaira T,Bambal RB,Pandya M,Khodor SA,Upadhyay DJ,Masuda N

更新日期：2019-03-27 00:00:00

abstract：:The direct or indirect interactions that antifungals have with the host immune response may play a significant role in defining their activity in vivo. However, the impact that acquired antifungal resistance has on the immunopharmacologic activity of antifungals is not well described. We assessed the immunopharmacolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Beyda ND,Liao G,Endres BT,Lewis RE,Garey KW

更新日期：2015-09-01 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00