Use of an efflux-deficient streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents.

abstract：:Prior investigations have suggested the use of a dosing weight correction factor of ideal body weight (IBW) plus 40% excess body weight (EBW, where EBW = total body weight [TBW] - IBW) to determine the weight to use for aminoglycoside dosing in morbidly obese (TBW/IBW ratio, > 2) patients. Little data are available to...

journal_title：Antimicrobial agents and chemotherapy

authors： Traynor AM,Nafziger AN,Bertino JS Jr

更新日期：1995-02-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Escherichia coli bearing a cryptic tetracycline resistance determinant from Bacteroides fragilis expressed low-level constitutive resistance to tetracycline under aerobic, but not anaerobic, growth conditions and accumulated less tetracycline aerobically than did isogenic susceptible cells. This decreased uptake was e...

journal_title：Antimicrobial agents and chemotherapy

authors： Park BH,Hendricks M,Malamy MH,Tally FP,Levy SB

更新日期：1987-11-01 00:00:00

abstract：:The in vivo efficacy of ciprofloxacin or pefloxacin alone or in combination with fosfomycin was evaluated in experimental aortic valve endocarditis induced in 133 rabbits by a multidrug-susceptible or multidrug-resistant strain of Pseudomonas aeruginosa. Therapy was initiated early (12 h after infection), when bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Potel G,Caillon J,Stephant G,Jehl F,Bugnon D,Le Conte P,Baron D,Drugeon H

更新日期：1995-02-01 00:00:00

abstract：:In vitro activity of ciprofloxacin against 27 strains of enterococci was inoculum dependent. Using inocula of 10(5) to 10(6) or 10(7) to 10(8) CFU of enterococci per ml, the MICs for 50 and 90% of strains tested increased from 1 to greater than or equal to 128 micrograms of ciprofloxacin per ml with the higher inoculu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandez-Guerrero M,Rouse MS,Henry NK,Geraci JE,Wilson WR

更新日期：1987-03-01 00:00:00

abstract：:Clinical pharmacological studies of ticarcillin (alpha-carboxyl-3-thienylmethyl penicillin, BRL-2288) were conducted in patients with metastatic cancer and leukemia. After administration of 0.5 g intramuscularly, 1 g intramuscularly, and 1 g intravenously, the mean peak concentrations in serum were 18, 35, and 106 mug...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez V,Inagaki J,Bodey GP

更新日期：1973-07-01 00:00:00

abstract：:New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Gevers T,Van Den Berg J,Andries K

更新日期：2008-10-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:Stereoselective disposition of sulbenicillin (SBPC) epimers in healthy human volunteers was studied in order to clarify the differences in pharmacokinetic behavior between the epimers. Stereospecific high-performance liquid chromatography was used for the determination of SBPC epimers. Plasma protein binding was measu...

journal_title：Antimicrobial agents and chemotherapy

authors： Itoh T,Watanabe N,Ishida M,Tsuda Y,Koyano S,Tsunoi T,Shimada H,Yamada H

更新日期：1998-02-01 00:00:00

abstract：:High-throughput screening of transposon insertion libraries is a useful strategy for unveiling bacterial genes whose inactivation results in an altered susceptibility to antibiotics. A potential drawback of these studies is they are usually based on just one model antibiotic for each structural family, under the assum...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanz-García F,Alvarez-Ortega C,Olivares-Pacheco J,Blanco P,Martínez JL,Hernando-Amado S

更新日期：2019-04-25 00:00:00

abstract：:Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium in...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano P,Recio S,Peláez T,González-Rivera M,Bouza E,Guinea J

更新日期：2012-01-01 00:00:00

abstract：:The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies carried out using ...

journal_title：Antimicrobial agents and chemotherapy

authors： VanScoy BD,Trang M,McCauley J,Conde H,Bhavnani SM,Friedrich LV,Alexander DC,Ambrose PG

更新日期：2016-06-20 00:00:00

abstract：:The quinolones inhibit the A subunit of DNA gyrase in the presence of Mg2+ by interrupting the DNA breakage and resealing steps, and the latter step is also retarded without quinolones if Mg2+ is replaced by Ca2+. Pyrimido[1,6-a]benzimidazoles have been found to represent a new class of potent DNA gyrase inhibitors wh...

journal_title：Antimicrobial agents and chemotherapy

authors： Gmünder H,Kuratli K,Keck W

更新日期：1995-01-01 00:00:00

abstract：:Bacterial susceptibility to a new organic acid related to nalidixic acid and oxolinic acid was tested. The in vitro susceptibility pattern of the new compound was found to be very similar to that of nalidixic acid. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gilis PM,Haemers A,Pattyn SR

更新日期：1978-03-01 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmici...

journal_title：Antimicrobial agents and chemotherapy

authors： K N Lam P,Tian Q,Ip M,Gomersall CD

更新日期：2010-02-01 00:00:00

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Ide K,Aoki M,Amano M,Koh Y,Yedidi RS,Das D,Leschenko S,Chapsal B,Ghosh AK,Mitsuya H

更新日期：2011-04-01 00:00:00

abstract：:The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cotroneo N,Rubio A,Critchley IA,Pillar C,Pucci MJ

更新日期：2020-07-22 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

更新日期：2009-09-01 00:00:00

abstract：:Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (defA) is not. Actin...

journal_title：Antimicrobial agents and chemotherapy

authors： Margolis P,Hackbarth C,Lopez S,Maniar M,Wang W,Yuan Z,White R,Trias J

更新日期：2001-09-01 00:00:00

abstract：:We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This r...

journal_title：Antimicrobial agents and chemotherapy

authors： Gollapudi SV,Chuah SK,Harvey T,Thadepalli HD,Thadepalli H

更新日期：1993-08-01 00:00:00

abstract：:The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173 recent clinical bite wound isolates were determined by agar dilution. Sparfloxacin was active against all strains (MIC for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1993-05-01 00:00:00

abstract：:Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients because of the drastic variability of the patients' physiological parameters. Published population PK studies have mainly focused on specific diseases, and the majority of these studies had small sample sizes. The aim of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen W,Zhang D,Lian W,Wang X,Du W,Zhang Z,Guo D,Zhang X,Zhan Q,Li P

更新日期：2020-05-21 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00

abstract：:The prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Bártolo I,Rocha C,Bartolomeu J,Gama A,Fonseca M,Mendes A,Cristina F,Thamm S,Epalanga M,Silva PC,Taveira N

更新日期：2009-07-01 00:00:00

abstract：:The epidemiology of the two common erythromycin resistance methylase (erm) genes ermA and ermC was analyzed by Southern blotting in 428 erythromycin-resistant Staphylococcus aureus strains isolated from blood between 1959 and 1988 in Denmark. ermA and/or ermC was present in 98% of the erythromycin-resistant strains te...

journal_title：Antimicrobial agents and chemotherapy

authors： Westh H,Hougaard DM,Vuust J,Rosdahl VT

更新日期：1995-02-01 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in compa...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai K,Tsuchimori N,Okonogi K,Perfect JR,Gotoh O,Yoshida Y

更新日期：1999-05-01 00:00:00