Stereoselective disposition of sulbenicillin in humans.

abstract：:Cyclic phosphate derivative of DHPG, 2'-nor-cGMP [9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne phosphate-oxide] was evaluated for activity against guinea pig cytomegalovirus (GPCMV) infection in cultured guinea pig embryo cells and in guinea pigs. By virus yield reduction and plaque reduction assays,...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ZH,Lucia HL,Tolman RL,Colonno RJ,Hsiung GD

更新日期：1989-09-01 00:00:00

abstract：:We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was prepared at one of two different lipid/AMB ratios (1 and 40) by incubating AMB with empty small unilamellar vesicles, made fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Bolard J,Saint-Julien L,Carbon C,Yeni P

更新日期：1992-02-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Biddlecome S,Haas M,Davies J,Miller GH,Rane DF,Daniels PJ

更新日期：1976-06-01 00:00:00

abstract：:The present study was designed to determine the temporal changes in tobramycin nephrotoxicity during the dark and the light periods of the day and to look for the mechanisms of such changes. Female Sprague-Dawley rats (9 to 11 weeks old) were housed in a 14-h-light-10-h-dark cycle (lights on 0600 to 2000 h). A bolus o...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin L,Grenier L,Bergeron Y,Simard M,Bergeron MG,Labrecque G,Beauchamp D

更新日期：1994-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen associated with nosocomial pneumonia and is an increasing threat for severe community-acquired pneumonia. We have now investigated the role of interleukin-12 (IL-12) in protective immunity against lung infection with MRSA. The importance of IL-12 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen QT,Furuya Y,Roberts S,Metzger DW

更新日期：2015-10-01 00:00:00

abstract：:The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in compa...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai K,Tsuchimori N,Okonogi K,Perfect JR,Gotoh O,Yoshida Y

更新日期：1999-05-01 00:00:00

abstract：:This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzitko K,Paneth A,Plech T,Pawełczyk J,Węglińska L,Paneth P

更新日期：2014-12-01 00:00:00

abstract：:Malaria is the third most significant cause of infectious disease in the world. The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to classical drugs. Trioxaquines are synthetic hybrid molecules containing a trioxane motif (which is responsible for the antimalarial a...

journal_title：Antimicrobial agents and chemotherapy

authors： Benoit-Vical F,Lelièvre J,Berry A,Deymier C,Dechy-Cabaret O,Cazelles J,Loup C,Robert A,Magnaval JF,Meunier B

更新日期：2007-04-01 00:00:00

abstract：:Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many prote...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura RL,Burlingame MA,Yang S,Crosby DC,Talbot DJ,Chui K,Frankel AD,Renslo AR

更新日期：2017-06-27 00:00:00

abstract：:Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with Taenia solium cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rates in NCC. Racemic a...

journal_title：Antimicrobial agents and chemotherapy

authors： Paredes A,de Campos Lourenço T,Marzal M,Rivera A,Dorny P,Mahanty S,Guerra-Giraldez C,García HH,Nash TE,Cass QB,Cysticercosis Working Group in Peru.

更新日期：2013-02-01 00:00:00

abstract：:The antiviral effects of four compounds, phosphonoacetate, phosphonoformate, acycloguanosine, and purified human lymphoblastic interferon, were tested against two neurotropic herpesviruses, herpesvirus platyrrhine and herpes simplex virus, and two oncogenic herpesviruses, herpesvirus saimiri and herpesvirus ateles. Al...

journal_title：Antimicrobial agents and chemotherapy

authors： Daniel MD,Falk LA,King NW,Tamulevich R,Holland JS,Bekesi JG

更新日期：1980-10-01 00:00:00

abstract：:A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range of antimalarial drugs. Its sensitivity allowed the use of parasite densities as low as 200 parasites/microl of blood. Be...

journal_title：Antimicrobial agents and chemotherapy

authors： Brockman A,Singlam S,Phiaphun L,Looareesuwan S,White NJ,Nosten F

更新日期：2004-04-01 00:00:00

abstract：:NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phe...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong-Bolduc QC,Strahilevitz J,Hooper DC

更新日期：2006-03-01 00:00:00

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00

abstract：:Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang W,Li Y,Qian G,Wang Y,Chen H,Li YZ,Liu F,Shen Y,Du L

更新日期：2011-12-01 00:00:00

abstract：:The racemic nucleoside analogue 2'-deoxy-3'-oxa-4'-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is structurally related to lamivudine (3TC), but the oxygen and sulfur in the furanosyl ring are transposed. Intracellular metabolism ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Muys JM,Gourdeau H,Nguyen-Ba N,Taylor DL,Ahmed PS,Mansour T,Locas C,Richard N,Wainberg MA,Rando RF

更新日期：1999-08-01 00:00:00

abstract：:Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their copr...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Ghilardi AC,Adams J,de Oliveira Garcia D,Paterson DL

更新日期：2007-09-01 00:00:00

abstract：:We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necro...

journal_title：Antimicrobial agents and chemotherapy

authors： Su F,Xue Y,Wang Y,Zhang L,Chen W,Hu S

更新日期：2015-09-01 00:00:00

abstract：:Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative p...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel L

更新日期：2012-04-01 00:00:00

abstract：:Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations among 139 MDR-TB iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao LL,Sun Q,Liu HC,Wu XC,Xiao TY,Zhao XQ,Li GL,Jiang Y,Zeng CY,Wan KL

更新日期：2015-04-01 00:00:00

abstract：:We recently identified a novel plasmid-mediated RND-type efflux pump gene cluster, tmexCD1-toprJ1 in Klebsiella pneumoniae, that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their function and tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang CZ,Gao X,Yang QW,Lv LC,Wan M,Yang J,Cai ZP,Liu JH

更新日期：2021-01-25 00:00:00

abstract：:Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV agent with potent in vitro and in vivo activity. RFI-641 is active against both RSV type A and B strains. The viral specif...

journal_title：Antimicrobial agents and chemotherapy

authors： Huntley CC,Weiss WJ,Gazumyan A,Buklan A,Feld B,Hu W,Jones TR,Murphy T,Nikitenko AA,O'Hara B,Prince G,Quartuccio S,Raifeld YE,Wyde P,O'Connell JF

更新日期：2002-03-01 00:00:00

abstract：:Ten strains each of 18 clinically important species of Clostridium were tested for susceptibility to clindamycin. Of the 180 strains tested, 56 (31%) were resistant to more than 1.6 mug/ml. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilkins TD,Thiel T

更新日期：1973-01-01 00:00:00

abstract：:Escherichia coli K-12 carrying the R-factor R1 or R6K is resistant to streptomycin. The resistance is due to R-factor-coded enzymes that metabolize the drug. Streptomycin can be inactivated in two ways, either by adenylylation or by phosphorylation; both reactions require adenosine 5'-triphosphate. In this work we sho...

journal_title：Antimicrobial agents and chemotherapy

authors： Lundbäck AK,Nordström K

更新日期：1974-05-01 00:00:00

abstract：:Amoxicillin when administered with gastric acid suppressors has been shown to be effective in eradication of Helicobacter pylori in 50 to 80% of subjects. The aim of this investigator-blind crossover study was to determine if gastric mucosal amoxicillin uptake was affected by increasing gastric juice pH. Fifteen male ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardaci G,Lambert JR,King RG,Onishi N,Midolo P

更新日期：1995-09-01 00:00:00

abstract：:Simocyclinone D8, a coumarin derivative isolated from Streptomyces antibioticus Tü 6040, represents an interesting new antiproliferative agent. It was originally suggested that this drug recognizes the GyrA subunit and interferes with the gyrase catalytic cycle by preventing its binding to DNA. To further characterize...

journal_title：Antimicrobial agents and chemotherapy

authors： Sissi C,Vazquez E,Chemello A,Mitchenall LA,Maxwell A,Palumbo M

更新日期：2010-01-01 00:00:00

abstract：:We have developed and validated a high-performance liquid chromatography method coupled with a mass detector to quantify itraconazole, voriconazole, and posaconazole using quinoxaline as the internal standard. The method involves protein precipitation with acetonitrile. Mean accuracy (percent deviation from the true v...

journal_title：Antimicrobial agents and chemotherapy

authors： Baietto L,D'Avolio A,Ventimiglia G,De Rosa FG,Siccardi M,Simiele M,Sciandra M,Di Perri G

更新日期：2010-08-01 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00