In vitro analysis of albendazole sulfoxide enantiomers shows that (+)-(R)-albendazole sulfoxide is the active enantiomer against Taenia solium.

abstract：:Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study examined the pharmacokinetics of the four first-line anti-TB drugs in ch...

journal_title：Antimicrobial agents and chemotherapy

authors： Antwi S,Yang H,Enimil A,Sarfo AM,Gillani FS,Ansong D,Dompreh A,Orstin A,Opoku T,Bosomtwe D,Wiesner L,Norman J,Peloquin CA,Kwara A

更新日期：2017-01-24 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing numbers of immune suppression techniques to treat other medical conditions and transplantation. Despite these advances, morbidity and mortality rates remain unacceptably high. One strategy used to optimize outcomes is antifungal pharma...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Marchillo K,Vanhecker J,Andes DR

更新日期：2013-12-01 00:00:00

abstract：:Chronic periodontitis is one of the most prevalent human diseases and is caused by dysbiosis of the subgingival microbiota. Treatment involves primarily mechanical disruption of subgingival biofilms and, in certain cases, adjunctive use of systemic antibiotic therapy. In vitro biofilm models have been developed to stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Soares GM,Teles F,Starr JR,Feres M,Patel M,Martin L,Teles R

更新日期：2015-05-01 00:00:00

abstract：:Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic, and metabolic prope...

journal_title：Antimicrobial agents and chemotherapy

authors： Lake P,DeLeo J,Cerasoli F,Logdberg L,Weetall M,Handley D

更新日期：2004-08-01 00:00:00

abstract：:We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was prepared at one of two different lipid/AMB ratios (1 and 40) by incubating AMB with empty small unilamellar vesicles, made fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Bolard J,Saint-Julien L,Carbon C,Yeni P

更新日期：1992-02-01 00:00:00

abstract：:We analyzed the didanosine (ddI) arm of the randomized, placebo-controlled Jaguar trial in order to define a genotypic score for ddI associated with virologic response. In this arm, 111 patients experiencing virologic failure received ddI in addition to their current combination therapy for 4 weeks. The impact of muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcelin AG,Flandre P,Pavie J,Schmidely N,Wirden M,Lada O,Chiche D,Molina JM,Calvez V,AI454-176 Jaguar Study Team.

更新日期：2005-05-01 00:00:00

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu M,Zeng R,Zhang L,Li D,Lv G,Shen Y,Zheng H,Zhang Q,Zhao J,Zheng N,Liu W

更新日期：2015-07-01 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

更新日期：2017-08-24 00:00:00

abstract：:Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

journal_title：Antimicrobial agents and chemotherapy

authors： Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

更新日期：2016-06-20 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

更新日期：2005-08-01 00:00:00

abstract：:Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-beta-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within C...

journal_title：Antimicrobial agents and chemotherapy

authors： Villegas MV,Lolans K,del Rosario Olivera M,Suarez CJ,Correa A,Queenan AM,Quinn JP,Colombian Nosocomial Resistance Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Mycobacterium abscessus is intrinsically resistant to many antimycobacterial antibiotics, which presents serious problems in therapy. Here, we describe the development of a novel phenotype-based microscopic and computerized imaging drug screening approach. A pilot screen of 568 compounds from two libraries identified ...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter A,Strauch A,Chao J,Ko M,Av-Gay Y

更新日期：2018-08-27 00:00:00

abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Schwartz JA,Stevens DA

更新日期：2012-08-01 00:00:00

abstract：:2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demons...

journal_title：Antimicrobial agents and chemotherapy

authors： Stuyver LJ,McBrayer TR,Whitaker T,Tharnish PM,Ramesh M,Lostia S,Cartee L,Shi J,Hobbs A,Schinazi RF,Watanabe KA,Otto MJ

更新日期：2004-02-01 00:00:00

abstract：:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen Pseudomonas aeruginosa in the presence of the glycoprotein mucin, which is found in high abundance at mucosal surfaces, especially those of the lungs of cystic fibrosis and bronchiectasis patients. Here, we investigated the ada...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun E,Gill EE,Falsafi R,Yeung A,Liu S,Hancock REW

更新日期：2018-08-27 00:00:00

abstract：:The dissociation constants for binding to ribosomes from Escherichia coli and concentrations at which 50% inhibition of [(14)C]erythromycin binding to ribosomes occurred were determined for 45 erythromycin analogues. These values were correlated with their antibacterial activities against Bacillus subtilis. Compounds ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pestka S,Lemahieu R,Miller P

更新日期：1974-10-01 00:00:00

abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

更新日期：2008-06-01 00:00:00

abstract：:Polyhexylcyanoacrylate nanoparticles loaded with either the human immunodeficiency virus (HIV) protease inhibitor saquinavir (Ro 31-8959) or the nucleoside analog zalcitabine (2',3'-dideoxycytidine) were prepared by emulsion polymerization and tested for antiviral activity in primary human monocytes/macrophages in vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bender AR,von Briesen H,Kreuter J,Duncan IB,Rübsamen-Waigmann H

更新日期：1996-06-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of human immunodeficiency virus-infected patients at our hospital. The results from four patients who were on long-term (> or = 6 months) combination therapy with zidovudine an...

journal_title：Antimicrobial agents and chemotherapy

authors： Burger DM,Meenhorst PL,Koks CH,Beijnen JH

更新日期：1993-07-01 00:00:00

abstract：:In a previous study we have shown that cultured epithelial cell lines can be used to measure the transepithelial passage of antimicrobial agents across the intestine and to obtain information on the mechanisms of transport utilized and predict the bioavailability of the antimicrobial agents after oral administration. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranaldi G,Islam K,Sambuy Y

更新日期：1994-06-01 00:00:00

abstract：:We determined the complete nucleotide sequence of a self-transmissible IncL/M plasmid, pKOI-34, from a Klebsiella oxytoca isolate. pKOI-34 possessed the core structure of an IncL/M plasmid found in Erwinia amylovora, pEL60, with two mobile elements inserted, a transposon carrying the arsenic resistance operon and a Tn...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Kayama S,Shigemoto N,Hisatsune J,Kuwahara R,Nishio H,Yamasaki K,Wada Y,Sueda T,Ohge H,Sugai M

更新日期：2016-04-22 00:00:00

abstract：:Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksey RC,Facklam RR,Thornsberry C

更新日期：1978-04-01 00:00:00

abstract：:Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmici...

journal_title：Antimicrobial agents and chemotherapy

authors： K N Lam P,Tian Q,Ip M,Gomersall CD

更新日期：2010-02-01 00:00:00

abstract：:Community-associated infections due to Escherichia coli producing CTX-M-type extended-spectrum β-lactamases are increasingly recognized in the United States. The bla(CTX-M) genes are frequently carried on IncF group plasmids. In this study, bla(CTX-M-15)-harboring plasmids pCA14 (sequence type 131 [ST131]) and pCA28 (...

journal_title：Antimicrobial agents and chemotherapy

authors： Li JJ,Spychala CN,Hu F,Sheng JF,Doi Y

更新日期：2015-01-01 00:00:00

abstract：:Southeast Asia (the Thailand-Cambodia border) has been considered the primal epicenter for most antimalarial drug resistance; however, numerous molecular epidemiological studies have successively reported multiple independent origins of sulfadoxine-pyrimethamine (SP) resistance-associated Plasmodium falciparum dhfr (p...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Yan H,Wei G,Han S,Huang Y,Zhang Q,Pan W

更新日期：2014-01-01 00:00:00