Antimicrobial therapy of experimental group B streptococcal infection in mice.

Abstract:

:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with gentamicin plus ampicillin or ampicillin alone. Untreated mice died within 10 to 48 h. Compared with treatment with ampicillin alone, ampicillin-and-gentamicin therapy resulted in improved survival when the antibiotics were given in established infection or as a single dose at the time of infection. Ampicillin and gentamicin accelerated the clearing of bacteremia as compared with treatment with ampicillin alone. In view of these findings, the therapy of GB-BHS infection in newborns and other patients should be reconsidered in that a combination of ampicillin or penicillin G plus gentamicin might be superior to the use of ampicillin or penicillin G alone.

authors

Deveikis A,Schauf V,Mizen M,Riff L

doi

10.1128/aac.11.5.817

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

817-20

issue

5

eissn

0066-4804

issn

1098-6596

journal_volume

11

pub_type

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