In vitro antimicrobial activity of benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex, determined by the radiometric method.

abstract：:The creation of new chemotherapeutic regimens that permit shortening the duration of treatment is a major priority for antituberculosis drug development. In this study, we used the murine model of experimental tuberculosis therapy to determine whether incorporation of the investigational new nitroimidazopyran PA-824 i...

journal_title：Antimicrobial agents and chemotherapy

authors： Nuermberger E,Rosenthal I,Tyagi S,Williams KN,Almeida D,Peloquin CA,Bishai WR,Grosset JH

更新日期：2006-08-01 00:00:00

abstract：:BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pozzi C,De Luca F,Benvenuti M,Poirel L,Nordmann P,Rossolini GM,Mangani S,Docquier JD

更新日期：2016-11-21 00:00:00

abstract：:The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between th...

journal_title：Antimicrobial agents and chemotherapy

authors： Salfinger M,Heifets LB

更新日期：1988-07-01 00:00:00

abstract：:The pharmacodynamic effects of metronidazole on Trichomonas vaginalis have been poorly characterized. The present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). Five laboratory strains and five...

journal_title：Antimicrobial agents and chemotherapy

authors： Nix DE,Tyrrell R,Müller M

更新日期：1995-08-01 00:00:00

abstract：:Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： P SH,Solapure S,Mukherjee K,Nandi V,Waterson D,Shandil R,Balganesh M,Sambandamurthy VK,Raichurkar AK,Deshpande A,Ghosh A,Awasthy D,Shanbhag G,Sheikh G,McMiken H,Puttur J,Reddy J,Werngren J,Read J,Kumar M,R M,Chi

更新日期：2014-01-01 00:00:00

abstract：:Helicobacter pylori is killed in vitro by polyoxyethylene acyl esters and ethers similar to simethicone emulsifiers in therapeutic antifoams. The MBC of these compounds for Helicobacter pylori was less than 20 micrograms/ml, while other gram-negative bacteria were unaffected by much higher concentrations of up to 50 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Kane AV,Plaut AG

更新日期：1996-02-01 00:00:00

abstract：:Multiple injections of ofloxacin (subcutaneous or oral) in combination with a Lactobacillus casei preparation, LC9018 (subcutaneous), in mice infected intravenously with Mycobacterium fortuitum led to a marked delay in the incidence of spinning disease, a lowered incidence of gross renal lesions, and an increase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Sato K,Saito H

更新日期：1990-04-01 00:00:00

abstract：:Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under sel...

journal_title：Antimicrobial agents and chemotherapy

authors： Orlén H,Hughes D

更新日期：2006-10-01 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:Surotomycin (formerly called CB-183,315) is a novel, orally administered cyclic lipopeptide antibacterial in development for the treatment of Clostridium difficile infection (CDI) that has potent activity against vancomycin-resistant enterococci (VRE) but limited activity against Gram-negative bacilli, including Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Deshpande A,Hurless K,Cadnum JL,Chesnel L,Gao L,Chan L,Kundrapu S,Polinkovsky A,Donskey CJ

更新日期：2016-05-23 00:00:00

abstract：:Population distributions and quality control data for strains of Pseudomonas aeruginosa tested for gentamicin susceptibility on six lots of Mueller-Hinton agar were analyzed. The lots of agar were used in three University of Washington hospitals from April 1975 through October 1977. The analyses indicated that the per...

journal_title：Antimicrobial agents and chemotherapy

authors： Pollock HM,Minshew BH,Kenny MA,Schoenknecht FD

更新日期：1978-09-01 00:00:00

abstract：:An analytical method for the quantitation of amifloxacin, 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid, in plasma and urine has been developed. The method involves extraction with chloroform, back-extraction into 0.1 M sodium hydroxide, and subsequent analysis by re...

journal_title：Antimicrobial agents and chemotherapy

authors： McCoy LF,Crawmer BP,Benziger DP

更新日期：1985-05-01 00:00:00

abstract：:Miloxacin, a synthetic antibacterial agent structurally related to oxolinic acid, has a broad spectrum of activity in vitro against gram-negative bacteria and considerable activity in vivo against infections with these bacteria. These observations led to studies on the absorption and excretion of miloxacin in mice, ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Izawa A,Yoshitake A,Komatsu T

更新日期：1980-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Coleman VR,Wilkie J,Levinson WE,Stevens T,Jawetz E

更新日期：1973-09-01 00:00:00

abstract：:DNA gyrase is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It is the accepted target of quinolones. The enzyme from Citrobacter freundii IID976 was purified by affinity chromatography on novobiocin-Sepharose and heparin-Sepharose. It had two subunits, designated A and B, which clo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoyama H,Sato K,Fujii T,Fujimaki K,Inoue M,Mitsuhashi S

更新日期：1988-01-01 00:00:00

abstract：:We describe the first IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19, which differed from IMP-2 by a single amino acid change (Arg to Ala at position 38). bla(IMP-19) was found within a class 1 integron located on a 35-kb plasmid. This is also the first description of an IMP producer in France. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neuwirth C,Siebor E,Robin F,Bonnet R

更新日期：2007-12-01 00:00:00

abstract：:The use of gentamicin to control contamination in a tissue culture system for the isolation of Chlamydia was investigated. Gentamicin, at concentrations up to 100 mug/ml, did not appear to inhibit the growth of stock chlamydial strains, as judged by assays for iodine-staining inclusions. When 343 cervical and urethral...

journal_title：Antimicrobial agents and chemotherapy

authors： Wentworth BB

更新日期：1973-06-01 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:Weak T-cell reactivity to hepatitis B virus (HBV) is thought to be the dominant cause for chronic HBV infection. Treatment with adefovir dipivoxil (ADV) increases the rate of HBV e antigen (HBeAg) loss; however, the immune mechanisms associated with this treatment response are not understood. Serial analysis of HBV-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksley H,Chokshi S,Maayan Y,Wedemeyer H,Andreone P,Gilson R,Warnes T,Paganin S,Zoulim F,Frederick D,Neumann AU,Brosgart CL,Naoumov NV

更新日期：2008-01-01 00:00:00

abstract：:The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively (with an MBC/MIC ratio of 1 to 2), and against 18 of the 21 species tested,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Labrousse V,Goh KS,De Sousa JP

更新日期：1991-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) strains belong to seven genotypes with numerous subtypes that respond differently to antiviral therapies. Genotype 1, and primarily subtype 1b, is the most prevalent genotype worldwide. The development of recombinant HCV infectious cell culture systems for different variants, permitted by the h...

journal_title：Antimicrobial agents and chemotherapy

authors： Pham LV,Ramirez S,Carlsen THR,Li YP,Gottwein JM,Bukh J

更新日期：2017-05-24 00:00:00

abstract：:A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An exce...

journal_title：Antimicrobial agents and chemotherapy

authors： Lichtenwalner DM,Suh B,Lorber B,Sugar AM

更新日期：1979-08-01 00:00:00

abstract：:An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-13...

journal_title：Antimicrobial agents and chemotherapy

authors： Prinarakis EE,Miriagou V,Tzelepi E,Gazouli M,Tzouvelekis LS

更新日期：1997-04-01 00:00:00

abstract：:The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Idelevich EA,Kriegeskorte A,Schleimer N,Peters G,von Eiff C,Becker K

更新日期：2018-03-27 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Ardanuy C,Tubau F,Liñares J,Domínguez MA,Pallarés R,Martín R,Spanish Pneumococcal Infection Study Network (G03\/103).

更新日期：2005-02-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:Iron-sulfur flavoproteins (Isf) are flavin mononucleotide (FMN)- and FeS cluster-containing proteins commonly encountered in anaerobic prokaryotes. However, with the exception of Isf from Methanosarcina thermophila, which participates in oxidative stress management by removing oxygen and hydrogen peroxide, none of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Smutná T,Pilarová K,Tarábek J,Tachezy J,Hrdý I

更新日期：2014-06-01 00:00:00

abstract：:Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the...

journal_title：Antimicrobial agents and chemotherapy

authors： Jekle A,Yoon J,Zuck M,Najafi R,Wang L,Shiau T,Francavilla C,Rani SA,Eitzinger C,Nagl M,Anderson M,Debabov D

更新日期：2013-02-01 00:00:00

abstract：:The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate in the parenteral treatment of systemic herpes simplex virus type 1 infections in Swiss mice were determined. Among cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Westbrook L,Arnett G,Daluge S,Lee H,Vince R

更新日期：1983-10-01 00:00:00