Serum protein binding of the aminoglycoside antibiotics.

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Li C,Lewis MR,Gilbert AB,Noel MD,Scoville DH,Allman GW,Savage PB

更新日期：1999-06-01 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

更新日期：2007-07-01 00:00:00

abstract：:Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

更新日期：2010-07-01 00:00:00

abstract：:We used information available from routine clinic visits to characterize the pharmacokinetics of didanosine in 82 human immunodeficiency virus-infected patients. A total of 271 blood samples were collected for the measurement of didanosine concentrations in plasma (mean +/- standard deviation [SD], 3.30 +/- 2.21 sampl...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams JM,Shelton MJ,Hewitt RG,Grasela TH,DeRemer M,Morse GD

更新日期：1998-04-01 00:00:00

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Korduláková J,Janin YL,Liav A,Barilone N,Dos Vultos T,Rauzier J,Brennan PJ,Gicquel B,Jackson M

更新日期：2007-11-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupont M,James CE,Chevalier J,Pagès JM

更新日期：2007-09-01 00:00:00

abstract：:The pharmacokinetics of an extended-release (XR) formulation of ciprofloxacin has been compared to that of the immediate-release (IR) product in healthy volunteers. The only significant difference in pharmacokinetic parameters between the two formulations was seen in the rate constant of absorption, which was approxim...

journal_title：Antimicrobial agents and chemotherapy

authors： Meagher AK,Forrest A,Dalhoff A,Stass H,Schentag JJ

更新日期：2004-06-01 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00

abstract：:The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when administered orally every 12 h for 7 days at doses of 100, 200, 300, 400, 600, and 800 mg. Steady-state maximum and minimum...

journal_title：Antimicrobial agents and chemotherapy

authors： Granneman GR,Carpentier P,Morrison PJ,Pernet AG

更新日期：1992-02-01 00:00:00

abstract：:Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

更新日期：1994-11-01 00:00:00

abstract：:BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Sanada M,Matsuda K,Hashizume T,Asahi Y,Ushijima R,Ohtake N,Tanaka N

更新日期：1989-09-01 00:00:00

abstract：:Echinocandins are important in the prevention and treatment of invasive candidiasis but limited by current dosing regimens that include daily intravenous administration. The novel echinocandin CD101 has a prolonged half-life of approximately 130 h in humans, making it possible to design once-weekly dosing strategies. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,VanScoy B,Ambrose PG,Andes DR

更新日期：2018-01-25 00:00:00

abstract：:Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is...

journal_title：Antimicrobial agents and chemotherapy

authors： de Aguiar Cordeiro R,de Farias Marques FJ,de Aguiar Cordeiro R,da Silva MR,Donato Maia Malaquias A,Silva de Melo CV,Mafezoli J,Ferreira de Oliveira Mda C,Nogueira Brilhante RS,Gadelha Rocha MF,Pinheiro Gomes Bandeira Tde J,Costa Si

更新日期：2014-05-01 00:00:00

abstract：:Using J774 macrophages, the intracellular activities of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) against Staphylococcus aureus (strain ATCC 25923) have been quantitatively assessed in a 24-h model. S. aureus was positively localized in phagolysosomes by confocal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Van Bambeke F,Tulkens PM

更新日期：2003-07-01 00:00:00

abstract：:Disseminated infections caused by the Mycobacterium avium-M. intracellulare complex (MAC) are the most frequent opportunistic bacterial infections in patients with AIDS. MAC isolates are resistant to many of the standard antituberculous drugs. Failure to obtain significant activities of certain drugs is due to difficu...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT

更新日期：1996-08-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hennequin C,Benailly N,Silly C,Sorin M,Scheinmann P,Lenoir G,Gaillard JL,Berche P

更新日期：1997-09-01 00:00:00

abstract：:We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonten MJ,Gaillard CA,van Tiel FH,van der Geest S,Stobberingh EE

更新日期：1995-12-01 00:00:00

abstract：:Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Montealegre MC,Roh JH,Rae M,Davlieva MG,Singh KV,Shamoo Y,Murray BE

更新日期：2016-12-27 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00

abstract：:Azoles are widely used antifungals; however, their efficacy is compromised by fungistatic activity and selection of resistant strains during treatment. Recent studies demonstrated roles for the protein kinase C and calcium signaling pathways in modulating azole activity. Here we explored a role for the signaling pathw...

journal_title：Antimicrobial agents and chemotherapy

authors： Jain P,Akula I,Edlind T

更新日期：2003-10-01 00:00:00

abstract：:Treatment of Escherichia coli K-10 with 100 mug of chloramphenicol per ml for periods greater than 30 min leads to progressive lysis and killing of cells. The bactericidal action of the antibiotic is dependent on cell growth and physiology; only rapidly dividing cells are susceptible to killing; resting or slowly grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Guota RS

更新日期：1975-06-01 00:00:00

abstract：:The killing of Candida albicans by a series of amphiphilic quaternary ammonium compounds (QACs) with different hydrocarbon chain lengths was closely related to the binding of the compounds to the cells and damage of the cell membranes. The membrane damage was measured as the level of release of the UV-absorbing materi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlström B,Chelminska-Bertilsson M,Thompson RA,Edebo L

更新日期：1997-03-01 00:00:00

abstract：:Gatifloxacin is an 8-methoxy fluoroquinolone effective against a broad spectrum of pathogens common in pediatric infections. The safety and pharmacokinetics of a single dose of gatifloxacin were studied in pediatric patients from 6 months to 16 years of age. Seventy-six pediatric patients (average age, 6.7 +/- 5.0 yea...

journal_title：Antimicrobial agents and chemotherapy

authors： Capparelli EV,Reed MD,Bradley JS,Kearns GL,Jacobs RF,Damle BD,Blumer JL,Grasela DM

更新日期：2005-03-01 00:00:00

abstract：:Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and a disk diffusion method. PCR was used to test drug-resistant genes, and the χ(2) test and definite probability methods were used to test for statistically significant differences among the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yin J,Yu S,Liu X,Li Y,Gao W,Ma X,Yang Y

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this investigation was to assess the influence that treatment with antacid and ranitidine had on the pharmacokinetics of oral cefetamet pivoxil in 18 healthy male volunteers. Each subject received, in an open-labeled, randomized, three-way crossover design, a single oral dose of 1,000 mg (two tablets) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Blouin RA,Kneer J,Ambros RJ,Stoeckel K

更新日期：1990-09-01 00:00:00