Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii.

abstract：:Staphylococcus epidermidis is a major cause of nosocomial infections because of its ability to form biofilms on the surface of medical devices. Only a few antibacterial agents are relatively active against biofilms, and rifampin, a transcription inhibitor, ranks among the most effective molecules against biofilm-relat...

journal_title：Antimicrobial agents and chemotherapy

authors： Villain-Guillot P,Gualtieri M,Bastide L,Leonetti JP

更新日期：2007-09-01 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00

abstract：:Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Brajtburg J,Elberg S,Kobayashi GS,Medoff G

更新日期：1988-03-01 00:00:00

abstract：:The chromosome-encoded class C β-lactamase CHE-1 produced by Enterobacter cloacae exhibits a lower sensitivity to avibactam than the P99 enzyme from which it is derived by a 6-residue deletion in the H-10 helix. In the present study, we investigated the sensitivity of CHE-1 to two other β-lactamase inhibitors: LK-157 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernea A,Galleni M,Frère JM

更新日期：2016-01-04 00:00:00

abstract：:ABT-492 is a novel quinolone with potent activity against gram-positive, gram-negative, and atypical pathogens, making this compound an ideal candidate for the treatment of community-acquired pneumonia. We therefore compared the in vitro pharmacodynamic activity of ABT-492 to that of levofloxacin, an antibiotic common...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson SM,Hayes RA,Quinn JP,Danziger LH

更新日期：2004-01-01 00:00:00

abstract：:Fecal samples from Illinois farm animals and Montana range cattle were examined for the frequency of gram-negative enteric organisms resistant to oxytetracycline, dihydrostreptomycin, or ampicillin. The Illinois farm animals were continually fed rations containing various antibacterial drugs. The Montana range cattle ...

journal_title：Antimicrobial agents and chemotherapy

authors： Siegel D,Huber WG,Enloe F

更新日期：1974-12-01 00:00:00

abstract：:Lupeol, which shows in vitro inhibitory activity against Plasmodium falciparum 3D7 strain with a 50% inhibitory concentration (IC50) of 27.7 +/- 0.5 microM, was shown to cause a transformation of the human erythrocyte shape toward that of stomatocytes. Good correlation between the IC50 value and the membrane curvature...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziegler HL,Staerk D,Christensen J,Hviid L,Hägerstrand H,Jaroszewski JW

更新日期：2002-05-01 00:00:00

abstract：:Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks virus entry into its ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Balzarini J,François KO,Van Laethem K,Hoorelbeke B,Renders M,Auwerx J,Liekens S,Oki T,Igarashi Y,Schols D

更新日期：2010-04-01 00:00:00

abstract：:A self-transferable plasmid of ca. 80 kb, pIP1204, conferred multiple-antibiotic resistance to Klebsiella pneumoniae BM4536, which was isolated from a urinary tract infection. Resistance to beta-lactams was due to the bla(TEM1) and bla(CTX-M) genes, resistance to trimethroprim was due to the dhfrXII gene, resistance t...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2003-08-01 00:00:00

abstract：:The pace of resistance against antibiotics almost exceeds that of the development of new drugs. As many bacteria have become resistant to conventional antibiotics, new drugs or drug resources are badly needed to combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobi...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Z,Ma Y,Dai C,Zhao R,Li S,Wu Y,Cao Z,Li W

更新日期：2009-08-01 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant, 523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and teicoplanin (MIC = 5 micrograms/ml) and elaborates a ca. 39-kDa cytoplasmic protein that was not detected in the parent strain 523 (MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski WM,Boyle-Vavra S,Moreira B,Ebert CC,Daum RS

更新日期：1996-01-01 00:00:00

abstract：:In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

journal_title：Antimicrobial agents and chemotherapy

authors： Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

更新日期：2005-01-01 00:00:00

abstract：:Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levonadifloxacin fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodvold KA,Gotfried MH,Chugh R,Gupta M,Yeole R,Patel A,Bhatia A

更新日期：2018-02-23 00:00:00

abstract：:The in vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of the MICs and minimum bactericidal concentrations (MBCs), timed killing, single-step and multistep mutation rates, the erythromycin indu...

journal_title：Antimicrobial agents and chemotherapy

authors： Woosley LN,Castanheira M,Jones RN

更新日期：2010-05-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dortet L,Bernabeu S,Gonzalez C,Naas T

更新日期：2017-07-25 00:00:00

abstract：:We report a microanalytical high-performance liquid chromatography method for quantitation of cefpirome (HR 810) from serum. The drug was extracted from 0.05 ml of serum with 0.2 ml of isopropanol containing beta-hydroxypropyltheophylline, the internal standard. Separations were performed on a C18 column at ambient te...

journal_title：Antimicrobial agents and chemotherapy

authors： Turley CP,Kearns GL,Jacobs RF

更新日期：1988-10-01 00:00:00

abstract：:Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metab...

journal_title：Antimicrobial agents and chemotherapy

authors： Hufford CD,Baker JK,McChesney JD,Clark AM

更新日期：1986-08-01 00:00:00

abstract：:SCCmec is a mobile genetic element that carries the gene (mecA) mediating methicillin resistance in staphylococci. For Staphylococcus aureus, four SCCmec types have been described, one (type IV) of which has been associated with newly identified community-acquired methicillin-resistant S. aureus. However, the distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wisplinghoff H,Rosato AE,Enright MC,Noto M,Craig W,Archer GL

更新日期：2003-11-01 00:00:00

abstract：:The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatel...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou Z,Griffing SM,de Oliveira AM,McCollum AM,Quezada WM,Arrospide N,Escalante AA,Udhayakumar V

更新日期：2008-02-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00

abstract：:The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMAU to generate a var...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler MM,Lamarr WA,Foster KA,Barnes MH,Skow DJ,Lyden PT,Kustigian LM,Zhi C,Brown NC,Wright GE,Bowlin TL

更新日期：2007-01-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bauernfeind A,Stemplinger I,Jungwirth R,Giamarellou H

更新日期：1996-01-01 00:00:00

abstract：:Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine if VPA affects the plasma concentration of efavirenz (EFV) or lopinavir. HIV type 1 (HIV-1)-infected patients receiving EFV or lopinavi...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson D,Cruttenden K,Morse G,Riggs G,Gelbard H,Schifitto G

更新日期：2004-11-01 00:00:00

abstract：:Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure of A. flavus to subinhibitory concentrations of VRC in vitro cau...

journal_title：Antimicrobial agents and chemotherapy

authors： Ukai Y,Kuroiwa M,Kurihara N,Naruse H,Homma T,Maki H,Naito A

更新日期：2018-10-24 00:00:00

abstract：:Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlat...

journal_title：Antimicrobial agents and chemotherapy

authors： Karema C,Imwong M,Fanello CI,Stepniewska K,Uwimana A,Nakeesathit S,Dondorp A,Day NP,White NJ

更新日期：2010-01-01 00:00:00

abstract：:The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin w...

journal_title：Antimicrobial agents and chemotherapy

authors： Greaves WL,Kreeft JH,Ogilvie RI,Richards GK

更新日期：1981-02-01 00:00:00

abstract：:Enzyme-mediated immunoassay (EMIT) serum aminoglycoside assay results were accurate and precise and correlated well with radioimmunoassay, fluoroimmunoassay, and acetyltransferase and microbiological assay determinations. ...

journal_title：Antimicrobial agents and chemotherapy

authors： White LO,Scammell LM,Reeves DS

更新日期：1981-06-01 00:00:00