Quantification, qualification, and microbial killing efficiencies of antimicrobial chlorine-based substances produced by iontophoresis.

abstract：:Gatifloxacin is an 8-methoxy fluoroquinolone effective against a broad spectrum of pathogens common in pediatric infections. The safety and pharmacokinetics of a single dose of gatifloxacin were studied in pediatric patients from 6 months to 16 years of age. Seventy-six pediatric patients (average age, 6.7 +/- 5.0 yea...

journal_title：Antimicrobial agents and chemotherapy

authors： Capparelli EV,Reed MD,Bradley JS,Kearns GL,Jacobs RF,Damle BD,Blumer JL,Grasela DM

更新日期：2005-03-01 00:00:00

abstract：:Beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae have been emerging in some countries, including Japan. The Clinical and Laboratory Standards Institute has only a susceptible MIC breakpoint (< or = 1 microg/ml) for piperacillin-tazobactam and a disclaimer comment that BLNAR H. in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirakata Y,Ohmori K,Mikuriya M,Saika T,Matsuzaki K,Hasegawa M,Hatta M,Yamamoto N,Kunishima H,Yano H,Kitagawa M,Arai K,Kawakami K,Kobayashi I,Jones RN,Kohno S,Yamaguchi K,Kaku M

更新日期：2009-10-01 00:00:00

abstract：:The effects of eight contact lens solutions on a Mastigina sp., which was associated with the infected eye of a patient, were studied. The solutions which killed the organism promptly were those which are used for gas-permeable and hard contact lenses. Some solutions for soft contact lenses were more effective than ot...

journal_title：Antimicrobial agents and chemotherapy

authors： Niszl IA,Markus MB,van Deventer JM

更新日期：1995-10-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:Amoxicillin when administered with gastric acid suppressors has been shown to be effective in eradication of Helicobacter pylori in 50 to 80% of subjects. The aim of this investigator-blind crossover study was to determine if gastric mucosal amoxicillin uptake was affected by increasing gastric juice pH. Fifteen male ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardaci G,Lambert JR,King RG,Onishi N,Midolo P

更新日期：1995-09-01 00:00:00

abstract：:A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jung H,Medina R,Castro N,Corona T,Sotelo J

更新日期：1997-06-01 00:00:00

abstract：:A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of m...

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Guiot HF,Mattie H,van Furth R

更新日期：1991-05-01 00:00:00

abstract：:We determined the pharmacodynamic parameter and the magnitude of that parameter that was predictive of the efficacy of fluconazole in the treatment of disseminated candidiasis. We used a neutropenic murine model of disseminated Candida albicans infection to characterize the time course of activity of fluconazole. Quan...

journal_title：Antimicrobial agents and chemotherapy

authors： Andes D,van Ogtrop M

更新日期：1999-09-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Tuberculosis (TB) treatment is long and requires multiple drugs, likely due to various phenotypes of TB bacilli with variable drug susceptibilities. Drugs with broad activity are urgently needed. This study aimed to evaluate delamanid's activity against growing or dormant bacilli in vitro as well as in vivo Cultures o...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen X,Hashizume H,Tomishige T,Nakamura I,Matsuba M,Fujiwara M,Kitamoto R,Hanaki E,Ohba Y,Matsumoto M

更新日期：2017-05-24 00:00:00

abstract：:The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were determined, and the virulence-suppressing effects of AZM were compared with those of erythromycin (EM), roxithromycin (RXM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizukane R,Hirakata Y,Kaku M,Ishii Y,Furuya N,Ishida K,Koga H,Kohno S,Yamaguchi K

更新日期：1994-03-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

journal_title：Antimicrobial agents and chemotherapy

authors： Teuber M,Bader J

更新日期：1976-01-01 00:00:00

abstract：:This study determined the pharmacokinetic disposition of cefonicid. A single dose of 7.5 mg/kg of body weight was administered to five healthy volunteers as a 5-min intravenous infusion. Multiple plasma and urine samples were collected for 48 h. Peak plasma concentrations ranged from 95 to 156 micrograms/ml and fell s...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Hatheway GJ,Gambertoglio JG,Lin ET,Conte JE Jr

更新日期：1982-06-01 00:00:00

abstract：:Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have potentially serious toxicities, and when given as intramuscular injections, dosing can be painful. Adv...

journal_title：Antimicrobial agents and chemotherapy

authors： Dharmadhikari AS,Kabadi M,Gerety B,Hickey AJ,Fourie PB,Nardell E

更新日期：2013-06-01 00:00:00

abstract：:We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were used to explore the...

journal_title：Antimicrobial agents and chemotherapy

authors： Rossi B,Soubirou JF,Chau F,Massias L,Dion S,Lepeule R,Fantin B,Lefort A

更新日期：2015-11-02 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozano S,Gamallo P,González-Cortés C,Presa Matilla JL,Fairhurst RM,Herreros E,Amaratunga C,Rodrigues J

更新日期：2018-11-26 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydroartemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Salman S,Benjamin J,Page-Sharp M,Yadi G,Batty KT,Siba PM,Mueller I,Davis TM

更新日期：2015-07-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:18F-labeled fleroxacin was used to measure the pharmacokinetics of fleroxacin in healthy and infected animals by positron emission tomography (PET) and tissue radioactivity measurements. In all experiments, a pharmacological dose of unlabeled drug (10 mg/kg) was coinjected with the tracer. The pharmacokinetics of [18F...

journal_title：Antimicrobial agents and chemotherapy

authors： Fischman AJ,Livni E,Babich J,Alpert NM,Liu YY,Thom E,Cleeland R,Prosser BL,Callahan RJ,Correia JA

更新日期：1992-10-01 00:00:00

abstract：:The Cpx stress response is widespread among Enterobacteriaceae We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA....

journal_title：Antimicrobial agents and chemotherapy

authors： Masi M,Pinet E,Pagès JM

更新日期：2020-05-21 00:00:00

abstract：:Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to detect the prevalen...

journal_title：Antimicrobial agents and chemotherapy

authors： Saravolatz SN,Martin H,Pawlak J,Johnson LB,Saravolatz LD

更新日期：2014-06-01 00:00:00

abstract：:SM-8668 (Sch 39304) is a new oral antifungal agent which we evaluated in comparison with fluconazole in various fungal infection models. The prophylactic effect of SM-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. The 50% effective dose for SM-8668 was assessed at 10 days a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanio T,Ichise K,Nakajima T,Okuda T

更新日期：1990-06-01 00:00:00

abstract：:The aims of this study were to describe the blood plasma (BP) and seminal plasma (SP) pharmacokinetics of tenofovir (TFV) in HIV-1-infected men, to assess the role of genetic polymorphism in the variability of TFV transfer into the male genital tract, and to evaluate the impact of TFV SP exposure on seminal plasma HIV...

journal_title：Antimicrobial agents and chemotherapy

authors： Valade E,Bouazza N,Lui G,Illamola SM,Benaboud S,Treluyer JM,Cobat A,Foissac F,De Sousa Mendes M,Chenevier-Gobeaux C,Suzan-Monti M,Rouzioux C,Assoumou L,Viard JP,Urien S,Ghosn J,Hirt D

更新日期：2017-02-23 00:00:00

abstract：:CL 188,624, CL 190,294, and CL 191,121 are novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems. The in vitro antibacterial activities of these THF carbapenems were evaluated and compared with those of biapenem, imipenem, and meropenem against 554 recent clinical isolates obtained from geographically dis...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Jacobus NV,Lin YI,Bitha P,Testa RT

更新日期：1999-03-01 00:00:00

abstract：:Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We re...

journal_title：Antimicrobial agents and chemotherapy

authors： Sherry L,Kean R,McKloud E,O'Donnell LE,Metcalfe R,Jones BL,Ramage G

更新日期：2017-08-24 00:00:00