Hydrogenosome metabolism is the key target for antiparasitic activity of resveratrol against Trichomonas vaginalis.

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there w...

journal_title：Antimicrobial agents and chemotherapy

authors： Perez HA,De la Rosa M,Apitz R

更新日期：1994-02-01 00:00:00

abstract：:Cyclic peptides with an even number of alternating d,l-alpha-amino acid residues are known to self-assemble into organic nanotubes. Such peptides previously have been shown to be stable upon protease treatment, membrane active, and bactericidal and to exert antimicrobial activity against Staphylococcus aureus and othe...

journal_title：Antimicrobial agents and chemotherapy

authors： Dartois V,Sanchez-Quesada J,Cabezas E,Chi E,Dubbelde C,Dunn C,Granja J,Gritzen C,Weinberger D,Ghadiri MR,Parr TR Jr

更新日期：2005-08-01 00:00:00

abstract：:The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoureaux TL,Frase H,Antunes NT,Vakulenko SB

更新日期：2012-11-01 00:00:00

abstract：:Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Blandizzi C,Malizia T,Batoni G,Ghelardi E,Baschiera F,Bruschini P,Senesi S,Campa M,Del Tacca M

更新日期：2002-05-01 00:00:00

abstract：:Tigemonam, a new monobactam with excellent activity against gram-negative bacteria, was evaluated for in vivo efficacy and absorption after oral administration to laboratory animals. Tigemonam is absorbed when administered orally to mice and dogs. In a variety of gram-negative systemic infections in mice, orally admin...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark JM,Olsen SJ,Weinberg DS,Dalvi M,Whitney RR,Bonner DP,Sykes RB

更新日期：1987-02-01 00:00:00

abstract：:Several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant Staphylococcus aureus MI339 and vancomycin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Zervosen A,Lu WP,Chen Z,White RE,Demuth TP Jr,Frère JM

更新日期：2004-03-01 00:00:00

abstract：:Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime....

journal_title：Antimicrobial agents and chemotherapy

authors： Nannini EC,Stryjewski ME,Singh KV,Rude TH,Corey GR,Fowler VG Jr,Murray BE

更新日期：2010-05-01 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:The pharmacokinetic properties of an everninomicin antibiotic (SCH27899; Ziracin) were studied with healthy Japanese male volunteers by single (1, 3, 6, and 9 mg/kg of body weight) and multiple 60-min intravenous infusions (3, 6, and 9 mg/kg once daily for 10 consecutive days following a 2-day interval after the initi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Kohno K,Kawato A,Takahashi K,Nagashima S,Kanamaru M

更新日期：2001-03-01 00:00:00

abstract：:TEM- and SHV-type extended-spectrum beta-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although substitutions at residues 104 (E to K), 164 (R to S or H), 238 (G to S...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Ruzin A,Tuckman M,Visalli MA,Petersen PJ,Bradford PA

更新日期：2009-03-01 00:00:00

abstract：:A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdon R,Polianski J,Gaudebout C,Marche C,Garry L,Pocidalo JJ

更新日期：1994-07-01 00:00:00

abstract：:Streptococcus pneumoniae is one of the leading pathogens that cause a variety of mucosal and invasive infections. With the increased emergence of multidrug-resistant S. pneumoniae, new antimicrobials with mechanisms of action different from conventional antibiotics are urgently needed. In this study, we identified a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang H,Gong Y,Zhang H,Etobayeva I,Miernikiewicz P,Luo D,Li X,Zhang X,Dąbrowska K,Nelson DC,He J,Wei H

更新日期：2019-03-27 00:00:00

abstract：:The molecular mechanisms of resistance to fluoroquinolones, tetracyclines, an aminocyclitol, macrolides, a lincosamide, a phenicol, and pleuromutilins were investigated in Mycoplasma bovis For the identification of mutations responsible for the high MICs of certain antibiotics, whole-genome sequencing of 35 M. bovis f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sulyok KM,Kreizinger Z,Wehmann E,Lysnyansky I,Bányai K,Marton S,Jerzsele Á,Rónai Z,Turcsányi I,Makrai L,Jánosi S,Nagy SÁ,Gyuranecz M

更新日期：2017-01-24 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00

abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

更新日期：2013-01-01 00:00:00

abstract：:Resistance of influenza viruses to antiviral drugs can emerge following medication or may result from natural variation. Two classes of anti-influenza virus drugs targeting either the M2 protein (amantadine and rimantadine) or neuraminidase (NA; oseltamivir and zanamivir) are currently licensed. These drugs are expect...

journal_title：Antimicrobial agents and chemotherapy

authors： Deyde VM,Nguyen T,Bright RA,Balish A,Shu B,Lindstrom S,Klimov AI,Gubareva LV

更新日期：2009-03-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:Treatment options are limited for implant-associated infections (IAI) that are mainly caused by biofilm-forming staphylococci. We report here on the activity of the serrulatane compound 8-hydroxyserrulat-14-en-19-oic acid (EN4), a diterpene isolated from the Australian plant Eremophila neglecta. EN4 elicited antimicro...

journal_title：Antimicrobial agents and chemotherapy

authors： Nowakowska J,Griesser HJ,Textor M,Landmann R,Khanna N

更新日期：2013-01-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:The physiological factors that contribute to Mycobacterium abscessus lung infections remain unclear. We determined whether antibiotic treatment targeting a major cystic fibrosis pathogen (i.e., Pseudomonas aeruginosa) could provide the ideal conditions for the establishment of M. abscessus infection. Our data showed t...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Sevilla G,Crabbé A,García-Coca M,Aguilera-Correa JJ,Esteban J,Pérez-Jorge C

更新日期：2019-10-22 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00

abstract：:A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An exce...

journal_title：Antimicrobial agents and chemotherapy

authors： Lichtenwalner DM,Suh B,Lorber B,Sugar AM

更新日期：1979-08-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta-lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1995-08-01 00:00:00

abstract：:Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical A...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1985-07-01 00:00:00

abstract：:Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ordonez P,Hamasaki T,Isono Y,Sakakibara N,Ikejiri M,Maruyama T,Baba M

更新日期：2012-05-01 00:00:00

abstract：:Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intr...

journal_title：Antimicrobial agents and chemotherapy

authors： Qu S,Dai C,Lang F,Hu L,Tang Q,Wang H,Zhang Y,Hao Z

更新日期：2018-12-21 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

更新日期：2013-11-01 00:00:00