Characterization of high-level quinolone resistance in Campylobacter jejuni.

abstract：:The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Padilla E,Alonso D,Doménech-Sánchez A,Gomez C,Pérez JL,Albertí S,Borrell N

更新日期：2006-06-01 00:00:00

abstract：:Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reactio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamaguchi M,Eda J,Kobayashi F,Mitsuhashi S

更新日期：1973-09-01 00:00:00

abstract：:Atazanavir (Reyataz; ATV) is a well-tolerated protease inhibitor (PI) that is indicated as a once-daily treatment for HIV infections. These features of ATV, combined with its virologic potency, make it particularly desirable for the treatment of HIV-infected pediatric patients. The objective of this study was to use a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong Y,Kowalski KG,Zhang J,Zhu L,Horga M,Bertz R,Pfister M,Roy A

更新日期：2011-12-01 00:00:00

abstract：:Resistance to rifampin in Mycobacterium tuberculosis results from mutations in the gene coding for the beta subunit of RNA polymerase (rpoB). At least 95% of rifampin-resistant isolates have mutations in rpoB, and the mutations are clustered in a small region. About 40 distinct point mutations and in-frame insertions ...

journal_title：Antimicrobial agents and chemotherapy

authors： Morlock GP,Plikaytis BB,Crawford JT

更新日期：2000-12-01 00:00:00

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult t...

journal_title：Antimicrobial agents and chemotherapy

authors： Fürnkranz U,Nagl M,Gottardi W,Köhsler M,Aspöck H,Walochnik J

更新日期：2008-02-01 00:00:00

abstract：:The pace of resistance against antibiotics almost exceeds that of the development of new drugs. As many bacteria have become resistant to conventional antibiotics, new drugs or drug resources are badly needed to combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobi...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Z,Ma Y,Dai C,Zhao R,Li S,Wu Y,Cao Z,Li W

更新日期：2009-08-01 00:00:00

abstract：:Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiskirchen DE,Nordmann P,Crandon JL,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuksa M,Krajden S,Lee A

更新日期：1984-09-01 00:00:00

abstract：:Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Reed MD,Stern RC,O'Brien CA,Crenshaw DA,Blumer JL

更新日期：1987-05-01 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00

abstract：:We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pultz NJ,Stiefel U,Ghannoum M,Helfand MS,Donskey CJ

更新日期：2005-01-01 00:00:00

abstract：:Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally experience rapid reinfection of their new liver graft. Current treatment protocols do not prevent graft reinfection and, in addition, an accelerated disease progression is observed. In the present study, we have evaluated a novel st...

journal_title：Antimicrobial agents and chemotherapy

authors： Meuleman P,Albecka A,Belouzard S,Vercauteren K,Verhoye L,Wychowski C,Leroux-Roels G,Palmer KE,Dubuisson J

更新日期：2011-11-01 00:00:00

abstract：:The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it an attractive target for antiviral therapies. Capsid assembly modulators (CAMs) induce the formation of empty capsid or aberrant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lahlali T,Berke JM,Vergauwen K,Foca A,Vandyck K,Pauwels F,Zoulim F,Durantel D

更新日期：2018-09-24 00:00:00

abstract：:The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cherubin CE,Corrado ML,Sierra MF,Gombert ME,Shulman M

更新日期：1981-10-01 00:00:00

abstract：:Sixteen weeks of treatment with clarithromycin (CLARI) alone displayed significant bactericidal activity against Mycobacterium avium complex infection in beige mice. Only two combined regimens, CLARI combined with an initial 4 or 8 weeks of amikacin (AMIKA), displayed activity greater than that displayed by CLARI alon...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Ji B,Truffot-Pernot C,Grosset J

更新日期：1995-03-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection does not generally cause problems in the immunocompetent adult but can result in severe clinical disease in the fetus, neonate, and immunocompromised host. Ganciclovir (GCV), the agent currently used to treat most HCMV infections, has resulted in much therapeutic success; however...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak RJ,Hartline CB,Qiu YL,Zemlicka J,Harden E,Marshall G,Sommadossi JP,Kern ER

更新日期：2000-06-01 00:00:00

abstract：:Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated a...

journal_title：Antimicrobial agents and chemotherapy

authors： McKessar SJ,Berry AM,Bell JM,Turnidge JD,Paton JC

更新日期：2000-11-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP), are relatively low...

journal_title：Antimicrobial agents and chemotherapy

authors： Font E,Rosario O,Santana J,García H,Sommadossi JP,Rodriguez JF

更新日期：1999-12-01 00:00:00

abstract：:Protoplasts of the temperature-sensitive osmotic-1 mutant of Neurospora crassa grew and divided as cell wall-less cells when incubated under certain conditions at 37 degrees C. Each protoplast regenerated cell wall and formed a mycelium when the temperature was shifted to 22 degrees C. Cell wall regeneration, but not ...

journal_title：Antimicrobial agents and chemotherapy

authors： Selitrennikoff CP

更新日期：1983-05-01 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa, PAe191, was found to be highly resistant to all anti-Pseudomonas beta-lactam antibiotics (except imipenem) and resistant also to aminoglycosides. It produced a beta-lactamase (with an apparent pI of 7.6) which was not inhibited by clavulanic acid. Cloning and characterizat...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugnier P,Casin I,Bouthors AT,Collatz E

更新日期：1998-12-01 00:00:00

abstract：:Staphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hertlein T,Sturm V,Lorenz U,Sumathy K,Jakob P,Ohlsen K

更新日期：2014-01-01 00:00:00

abstract：:Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

journal_title：Antimicrobial agents and chemotherapy

authors： Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

更新日期：2020-04-21 00:00:00

abstract：:Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for...

journal_title：Antimicrobial agents and chemotherapy

authors： Veiga MI,Osório NS,Ferreira PE,Franzén O,Dahlstrom S,Lum JK,Nosten F,Gil JP

更新日期：2014-12-01 00:00:00

abstract：:Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the fre...

journal_title：Antimicrobial agents and chemotherapy

authors： Leib DA,Ruffner KL,Hildebrand C,Schaffer PA,Wright GE,Coen DM

更新日期：1990-06-01 00:00:00

abstract：:The emergence of Neisseria gonorrhoeae isolates displaying resistance to antimicrobial agents is a major public health concern and a serious issue related to the occurrence of further untreatable gonorrhea infections. A retrospective analysis on 1,430 N. gonorrhoeae isolates, collected from 2003 through 2012, for anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Carannante A,Renna G,Dal Conte I,Ghisetti V,Matteelli A,Prignano G,Impara G,Cusini M,D'Antuono A,Vocale C,Antonetti R,Gaino M,Busetti M,Latino MA,Mencacci A,Bonanno C,Cava MC,Giraldi C,Stefanelli P

更新日期：2014-10-01 00:00:00

abstract：:PSE-2, a plasmid-mediated beta-lactamase which was previously considered pseudomonas specific, was observed in clinical isolates of Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, and Enterobacter cloacae. All four isolates transferred PSE-2 production, together with resistance to gentamicin, tobramycin...

journal_title：Antimicrobial agents and chemotherapy

authors： Livermore DM,Maskell JP,Williams JD

更新日期：1984-02-01 00:00:00

abstract：:We have attempted to validate in Aspergillus flavus the main in vitro methodologies that have been used to detect resistance in Aspergillus fumigatus. We developed a murine model with two A. flavus isolates, one that was apparently resistant in vitro to amphotericin B (AFL5) and another that was resistant to itraconaz...

journal_title：Antimicrobial agents and chemotherapy

authors： Mosquera J,Warn PA,Morrissey J,Moore CB,Gil-Lamaignere C,Denning DW

更新日期：2001-05-01 00:00:00

abstract：:We studied the resistance mechanism and antimicrobial effects of β-lactams on imipenem-resistant Pseudomonas aeruginosa isolates that were susceptible to ceftazidime as detected by time-kill curve methods. Among 215 P. aeruginosa isolates from hospitalized patients in eight hospitals in the Republic of Korea, 18 isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Wi YM,Choi JY,Lee JY,Kang CI,Chung DR,Peck KR,Song JH,Ko KS

更新日期：2017-05-24 00:00:00