Susceptibility testing of Aspergillus flavus: inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo.

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus...

journal_title：Antimicrobial agents and chemotherapy

authors： Gebremariam T,Alkhazraji S,Baldin C,Kovanda L,Wiederhold NP,Ibrahim AS

更新日期：2017-04-24 00:00:00

abstract：:An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on the MIC(90) of 0.06 microg/ml for Streptococcus pyogenes reported in the literature) was shown to be achievable in a phase 1 study of 23 children with a once-daily (QD) modified-release, multiparticulate formul...

journal_title：Antimicrobial agents and chemotherapy

authors： Pichichero ME,Casey JR,Block SL,Guttendorf R,Flanner H,Markowitz D,Clausen S

更新日期：2008-07-01 00:00:00

abstract：:The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldberg I,Walker JR,Bloch K

更新日期：1973-05-01 00:00:00

abstract：:SDZ MRL 953, a new synthetic monosaccharidic lipid A, was investigated in vitro and in vivo for immunopharmacological activities. In experimental models of microbial infections, the compound was highly protective when it was administered prophylactically either once or three times to myelosuppressed or immunocompetent...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam C,Schütze E,Hildebrandt J,Aschauer H,Liehl E,Macher I,Stütz P

更新日期：1991-03-01 00:00:00

abstract：:Rationally designed synthetic inhibitors of retroviral proteases inhibit the processing of viral polyproteins in cultures of human immunodeficiency virus type 1 (HIV-1)-infected T lymphocytes and, as a result, inhibit the infectivity of HIV-1 for such cultures. The ability of HIV-1 protease inhibitors to suppress repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Black PL,Downs MB,Lewis MG,Ussery MA,Dreyer GB,Petteway SR Jr,Lambert DM

更新日期：1993-01-01 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00

abstract：:The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against Corynebacterium spp., being more active than 14- and 16-membered macrolides, azithromycin, or clindamyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Martínez L,Pascual A,Suárez AI,Perea EJ

更新日期：1998-12-01 00:00:00

abstract：:Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. A target area under the concentration-time curve from 0 to 24 h (AUC0-24) of 40 to 50 μg · h/ml is recommended. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Q,Leroux S,Shi HY,Xu HY,Kou C,Khan MW,Jacqz-Aigrain E,Zhao W

更新日期：2018-04-26 00:00:00

abstract：:A membrane fraction from Pseudomonas aeruginosa KM 338 was shown to catalyze in vitro peptidoglycan synthesis from uridine 5'-diphosphate-N-acetylmuramyl-l-alanyl-d- glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine and uridine 5'-diphosphate-N-acetylglucosamine. Synthesized peptidoglycan was partially cross-linked by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H,Ichikawa A,Kotani S

更新日期：1974-12-01 00:00:00

abstract：:The intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime were studied in 68 volunteers who received single, oral doses of azithromycin (0.5 g), clarithormycin (0.5 g), ciprofloxacin (0.5 g), or cefuroxime (0.5 g). In subgroups of four subjects each, the subjects underwent bron...

journal_title：Antimicrobial agents and chemotherapy

authors： Conte JE Jr,Golden J,Duncan S,McKenna E,Lin E,Zurlinden E

更新日期：1996-07-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:Despite controversies associated with forms and value of antibiotic therapy for cystic fibrosis patients, antibiotherapy remains a cornerstone in the management of those patients. Locally administered liposome-encapsulated antibiotics may offer advantages over free antibiotics, including sustained concentration of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Beaulac C,Clément-Major S,Hawari J,Lagacé J

更新日期：1996-03-01 00:00:00

abstract：:Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1 integron in both isolates. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez-Martinez JM,Nordmann P,Fortineau N,Poirel L

更新日期：2010-01-01 00:00:00

abstract：:Implicated as a major mechanism of ethambutol (EMB) resistance in clinical studies of Mycobacterium tuberculosis, mutations in codon 306 of the embB gene (embB306) have also been detected in EMB-susceptible clinical isolates. Other studies have found strong associations between embB306 mutations and multidrug resistan...

journal_title：Antimicrobial agents and chemotherapy

authors： Safi H,Sayers B,Hazbón MH,Alland D

更新日期：2008-06-01 00:00:00

abstract：:Lupeol, which shows in vitro inhibitory activity against Plasmodium falciparum 3D7 strain with a 50% inhibitory concentration (IC50) of 27.7 +/- 0.5 microM, was shown to cause a transformation of the human erythrocyte shape toward that of stomatocytes. Good correlation between the IC50 value and the membrane curvature...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziegler HL,Staerk D,Christensen J,Hviid L,Hägerstrand H,Jaroszewski JW

更新日期：2002-05-01 00:00:00

abstract：:A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of human immunodeficiency virus-infected patients at our hospital. The results from four patients who were on long-term (> or = 6 months) combination therapy with zidovudine an...

journal_title：Antimicrobial agents and chemotherapy

authors： Burger DM,Meenhorst PL,Koks CH,Beijnen JH

更新日期：1993-07-01 00:00:00

abstract：:Numerous bacterial pathogens, particularly those that colonize fast-flow areas in the bladder and gastrointestinal tract, require motility to establish infection and spread beyond the initially colonized tissue. Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, e...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen L,White EL,Pathak A,Ayala JC,Wang H,Wu JH,Benitez JA,Silva AJ

更新日期：2011-09-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Binder U,Maurer E,Lackner M,Lass-Flörl C

更新日期：2015-03-01 00:00:00

abstract：:The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found that the loss of the putative calcium-dependent protein-encoding gene algA caus...

journal_title：Antimicrobial agents and chemotherapy

authors： Wei X,Chen P,Gao R,Li Y,Zhang A,Liu F,Lu L

更新日期：2016-12-27 00:00:00

abstract：:Mutations in the rifampin resistance-determining (Rif) regions of the rpoB gene of Staphylococcus aureus mutants obtained during therapy or in vitro were analyzed by gene amplification and sequencing. Each of the resistant clinical isolates, including five nonrelated clones and two strains isolated from the same patie...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry-Damon H,Soussy CJ,Courvalin P

更新日期：1998-10-01 00:00:00

abstract：:We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins LA,Wennersten CB,Ferraro MJ,Moellering RC Jr,Eliopoulos GM

更新日期：1994-01-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwebke JR,Barrientes FJ

更新日期：2006-12-01 00:00:00

abstract：:Pulmonary infiltrates in neutropenic hosts with invasive aspergillosis are due to vascular invasion and hemorrhagic infarction. In order to measure the effect of antifungal compounds on this organism-mediated tissue injury, we monitored the course of pulmonary infiltrates by serial ultrafast computerized tomography (U...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Garrett K,Feurerstein E,Girton M,Allende M,Bacher J,Francesconi A,Schaufele R,Pizzo PA

更新日期：1995-05-01 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:A combination of 3 g of ticarcillin and 200 mg of clavulanic acid was administered intravenously to six healthy male volunteers, after which the concentrations of these agents in serum and blister fluid were measured. The ratio of the two drugs in serum varied from 15:1 (ticarcillin-clavulanic acid) at the time of adm...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett S,Wise R,Weston D,Dent J

更新日期：1983-06-01 00:00:00

abstract：:We analyzed the didanosine (ddI) arm of the randomized, placebo-controlled Jaguar trial in order to define a genotypic score for ddI associated with virologic response. In this arm, 111 patients experiencing virologic failure received ddI in addition to their current combination therapy for 4 weeks. The impact of muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcelin AG,Flandre P,Pavie J,Schmidely N,Wirden M,Lada O,Chiche D,Molina JM,Calvez V,AI454-176 Jaguar Study Team.

更新日期：2005-05-01 00:00:00

abstract：:The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and elect...

journal_title：Antimicrobial agents and chemotherapy

authors： Thorn RM,Robinson GM,Reynolds DM

更新日期：2013-05-01 00:00:00