In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole.

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:Methionine gamma-lyase, the enzyme which catalyzes the single-step conversion of methionine to alpha-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms but has no counterpart in mammals. This study tested the hypothesis that this pathogen-specific enzyme can be exploi...

journal_title：Antimicrobial agents and chemotherapy

authors： Coombs GH,Mottram JC

更新日期：2001-06-01 00:00:00

abstract：:Wastewater is considered a major source of antibiotic-resistant bacteria released into the environment. Here, we characterized carbapenemase-producing Enterobacteriaceae (CPE) in wastewater by whole-genome analysis. Wastewater samples (n = 40) were collected from municipal wastewater treatment plants and hospital wast...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomi R,Matsuda T,Yamamoto M,Chou PH,Tanaka M,Ichiyama S,Yoneda M,Matsumura Y

更新日期：2018-04-26 00:00:00

abstract：:Gentamicin was successfully incorporated into neutral, anionic, and cationic liposomes, and the percentage of gentamicin incorporated was found to be a function of lipid concentration. Gentamicin did not leak out of the liposomes over a 3-week period at 4 degrees C. When liposome-associated gentamicin was administered...

journal_title：Antimicrobial agents and chemotherapy

authors： Morgan JR,Williams KE

更新日期：1980-04-01 00:00:00

abstract：:Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conf...

journal_title：Antimicrobial agents and chemotherapy

authors： Cagliero C,Mouline C,Cloeckaert A,Payot S

更新日期：2006-11-01 00:00:00

abstract：:Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metab...

journal_title：Antimicrobial agents and chemotherapy

authors： Hufford CD,Baker JK,McChesney JD,Clark AM

更新日期：1986-08-01 00:00:00

abstract：:Fragments (414 bp) of the gene-encoding ribosomal protein L16 from Enterococcus faecium and Enterococcus faecalis that were resistant and susceptible to the oligosaccharide antibiotics avilamycin and evernimicin (SCH 27899) were sequenced and compared. The susceptible E. faecalis and E. faecium isolates had sequences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarestrup FM,Jensen LB

更新日期：2000-12-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:Although controversial, it has been suggested that antibiotic treatment of laboratory animals infected with Borrelia burgdorferi often leads to the persistence of residual spirochetes that are claimed to be viable but noncultivable. If viable cells of B. burgdorferi do persist following antibiotic therapy, one possibl...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavia CS,Wormser GP

更新日期：2014-11-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:Enterococci are intrinsically resistant to low levels of aminoglycosides. We previously selected in vitro and in vivo Enterococcus faecalis with intermediate-level resistance to gentamicin that did not abolish synergism with a cell-wall-active agent (E. Aslangul et al., Antimicrob. Agents Chemother. 49:4144-4148, 2005...

journal_title：Antimicrobial agents and chemotherapy

authors： Aslangul E,Massias L,Meulemans A,Chau F,Andremont A,Courvalin P,Fantin B,Ruimy R

更新日期：2006-11-01 00:00:00

abstract：:We describe outcomes of patients with infections with carbapenem-resistant Klebsiella pneumoniae (CRKP) who received ertapenem-containing double-carbapenem therapy (ECDCT). Clinical success was observed in 7/18 (39%) patients overall: bloodstream infections, 3/7 (43%); pneumonia, 1/5 (20%); intraabdominal infections, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cprek JB,Gallagher JC

更新日期：2015-11-09 00:00:00

abstract：:Penicillin-binding protein (PBP) 2 is the major PBP of five that have been identified in susceptible strains of Staphylococcus aureus. Beta-lactam antibiotic binding to PBP 2 is important for the antibacterial effect. Antibiotic binding to PBP 2 in strain 209P was examined with sodium dodecyl sulfate-polyacrylamide ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Miick C

更新日期：1992-03-01 00:00:00

abstract：:The efficacy and safety of oral LY217896 for prevention of experimental influenza A/Kawasaki/86 (H1N1) virus infection were assessed in susceptible males randomly assigned to receive LY217896 (75 mg) or placebo once daily for 7 days beginning 24 h prior to viral challenge. The rates of virus shedding (100% in both gro...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayden FG,Tunkel AR,Treanor JJ,Betts RF,Allerheiligen S,Harris J

更新日期：1994-05-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and bla(CTX-M-2) was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 region...

journal_title：Antimicrobial agents and chemotherapy

authors： Valverde A,Cantón R,Galán JC,Nordmann P,Baquero F,Coque TM

更新日期：2006-02-01 00:00:00

abstract：:Rifabutin pharmacokinetics were studied by the population approach (NONMEM) with 40 human immunodeficiency virus-infected patients receiving rifabutin at different doses for prophylaxis or therapy of mycobacterial infections. A two-compartment open model with first-order absorption was used as the structural pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Papa P,Torre D,Andreoni M,Poggio A,Bassetti M,Marone P

更新日期：1998-08-01 00:00:00

abstract：:MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-f...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ

更新日期：1997-08-01 00:00:00

abstract：:The tight packing of six fatty acids in the lipid A constituent of lipopolysaccharide (LPS) has been proposed to contribute to the unusually low permeability of the outer membrane of gram-negative enteric bacteria to hydrophobic antibiotics. Here it is shown that the Escherichia coli msbB mutant, which elaborates defe...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Nurminen M

更新日期：1999-06-01 00:00:00

abstract：:In 2002, the first two clinical isolates of vancomycin-resistant Staphylococcus aureus (VRSA) containing vanA were recovered in Michigan and Pennsylvania. Tn1546, a mobile genetic element that encodes high-level vancomycin resistance in enterococci, was present in both isolates. With PCR and DNA sequence analysis, we ...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark NC,Weigel LM,Patel JB,Tenover FC

更新日期：2005-01-01 00:00:00

abstract：:We recently reported the chromosomal location of the staphylococcal beta-lactamase gene in four strains of Enterococcus faecalis. Transfer of this gene from strain CH19 to an enterococcal recipient was accompanied by transfer of numerous other antimicrobial resistance determinants in the absence of detectable plasmid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Marshall SH

更新日期：1992-09-01 00:00:00

abstract：:We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

更新日期：2017-04-24 00:00:00

abstract：:3-Decynoyl-N-acetylcystamine is known to inhibit the in vitro growth of Escherichia coli but not of yeasts or mammalian cells. Neither the free acid nor the 2 positional isomer is active (L. R. Kass, J. Biol. Chem. 243:3223-3228, 1968). Other studies have shown that 2-hexadecynoic acid is fungitoxic whereas most of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Konthikamee W,Gilbertson JR,Langkamp H,Gershon H

更新日期：1982-11-01 00:00:00

abstract：:Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. A target area under the concentration-time curve from 0 to 24 h (AUC0-24) of 40 to 50 μg · h/ml is recommended. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Q,Leroux S,Shi HY,Xu HY,Kou C,Khan MW,Jacqz-Aigrain E,Zhao W

更新日期：2018-04-26 00:00:00

abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

更新日期：2013-01-01 00:00:00

abstract：:The Bacteroides fragilis bacteriocin which inhibits ribonucleic acid (RNA) polymerase activity had a narrow activity spectrum in vivo and only inhibited the growth of certain B. fragilis strains. In vitro the bacteriocin was not specific and inhibited RNA polymerases from widely diverse bacterial genera. RNA polymeras...

journal_title：Antimicrobial agents and chemotherapy

authors： Mossie KG,Robb FT,Jones DT,Woods DR

更新日期：1981-10-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was examined by using specific inhibitors. Buthionine sulfoximine (BSO) significantly reversed the resistance to trivalent Sb (Sb(III)) of promastigotes of experimentally derived Sb-resistant lines, suppor...

journal_title：Antimicrobial agents and chemotherapy

authors： Goyeneche-Patino DA,Valderrama L,Walker J,Saravia NG

更新日期：2008-12-01 00:00:00