Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t...

journal_title：Antimicrobial agents and chemotherapy

authors： Baba M,De Clercq E,Iida S,Tanaka H,Nitta I,Ubasawa M,Takashima H,Sekiya K,Umezu K,Nakashima H

更新日期：1990-12-01 00:00:00

abstract：:Treatment of Escherichia coli K-10 with 100 mug of chloramphenicol per ml for periods greater than 30 min leads to progressive lysis and killing of cells. The bactericidal action of the antibiotic is dependent on cell growth and physiology; only rapidly dividing cells are susceptible to killing; resting or slowly grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Guota RS

更新日期：1975-06-01 00:00:00

abstract：:Antibiotic therapy is the most commonly used strategy to control pathogenic infections; however, it has contributed to the generation of antibiotic-resistant bacteria. To circumvent this emerging problem, we are searching for compounds that target bacterial virulence factors rather than their viability. Pseudomonas ae...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamazaki A,Li J,Zeng Q,Khokhani D,Hutchins WC,Yost AC,Biddle E,Toone EJ,Chen X,Yang CH

更新日期：2012-01-01 00:00:00

abstract：:A 7.7-kilobase BamHI fragment was cloned from the transconjugant of a clinical isolate of Escherichia coli containing a 120-kilobase multiresistance IncC plasmid. The recombinant plasmid conferred resistance to kanamycin, gentamicin, tobramycin, sulfamethoxazole, and trimethoprim. This clone was used to generate a ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Groot Obbink DJ,Ritchie LJ,Cameron FH,Mattick JS,Ackerman VP

更新日期：1985-07-01 00:00:00

abstract：:A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jung H,Medina R,Castro N,Corona T,Sotelo J

更新日期：1997-06-01 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:In a randomized, evaluator-blind, multicenter trial, we compared cefepime (2 g three times a day) with imipenem-cilastatin (500 mg four times a day) for the treatment of nosocomial pneumonia in 281 intensive care unit patients from 13 centers in six European countries. Of 209 patients eligible for per-protocol analysi...

journal_title：Antimicrobial agents and chemotherapy

authors： Zanetti G,Bally F,Greub G,Garbino J,Kinge T,Lew D,Romand JA,Bille J,Aymon D,Stratchounski L,Krawczyk L,Rubinstein E,Schaller MD,Chiolero R,Glauser MP,Cometta A,Cefepime Study Group,.

更新日期：2003-11-01 00:00:00

abstract：:Blastocystis is an enteric parasite with extensive global prevalence. Studies have linked infection with this protist with a variety of gastrointestinal disorders, including irritable bowel syndrome. Due to the polymorphic nature of Blastocystis, studies on the parasite could be complicated, as results can be easily m...

journal_title：Antimicrobial agents and chemotherapy

authors： Yason JA,Koh KARP,Tan KSW

更新日期：2018-07-27 00:00:00

abstract：:Susceptibility of pathogenic aerobic bacteria to moxalactam (LY127935) was compared by two methods, diffusion from 30-microgram disks and agar plate dilution. The two methods gave a satisfactory degree of correlation when compared by linear regression, but the slope of the linear regression was significantly steeper f...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ

更新日期：1981-01-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pathway is indispensable for Chlamydia growth. Previously, a high-conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Mojica SA,Salin O,Bastidas RJ,Sunduru N,Hedenström M,Andersson CD,Núñez-Otero C,Engström P,Valdivia RH,Elofsson M,Gylfe Å

更新日期：2017-09-22 00:00:00

abstract：:Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA). To determine whethe...

journal_title：Antimicrobial agents and chemotherapy

authors： Dillon NA,Peterson ND,Rosen BC,Baughn AD

更新日期：2014-12-01 00:00:00

abstract：:Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations among 139 MDR-TB iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao LL,Sun Q,Liu HC,Wu XC,Xiao TY,Zhao XQ,Li GL,Jiang Y,Zeng CY,Wan KL

更新日期：2015-04-01 00:00:00

abstract：:Mercury has a long history as an antimicrobial agent effective against eukaryotic and prokaryotic organisms. Despite its prolonged use, the basis for mercury toxicity in prokaryotes is not well understood. Archaea, like bacteria, are prokaryotes but they use a simplified version of the eukaryotic transcription apparat...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixit V,Bini E,Drozda M,Blum P

更新日期：2004-06-01 00:00:00

abstract：:A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia...

journal_title：Antimicrobial agents and chemotherapy

authors： Rudolf D,Michaylov N,van der Linden M,Hoy L,Klugman KP,Welte T,Pletz MW,CAPNETZ Study Group.

更新日期：2011-10-01 00:00:00

abstract：:Standard antituberculosis (anti-TB) therapy requires the use of multiple drugs for a minimum of 6 months, with variable outcomes that are influenced by a number of microbiological, pathological, and clinical factors. This is despite the availability of antibiotics that have good activity against Mycobacterium tubercul...

journal_title：Antimicrobial agents and chemotherapy

authors： Kjellsson MC,Via LE,Goh A,Weiner D,Low KM,Kern S,Pillai G,Barry CE 3rd,Dartois V

更新日期：2012-01-01 00:00:00

abstract：:Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of penicillin, ampicillin, cefoxitin, and cefuroxime were determined for 103 beta-lactamase-negative Neisseria gonorrhoeae clinical isolates belonging to five different auxotypes. MBC determinations were base on killing 99.9% of th...

journal_title：Antimicrobial agents and chemotherapy

authors： de Repentigny L,Turgeon PL

更新日期：1981-04-01 00:00:00

abstract：:Attenuated activity of echinocandin antifungals at high concentrations, known as the "paradoxical effect," is a well-established phenomenon in Candida albicans and Aspergillus fumigatus. In the yeast C. albicans, upregulation of chitin biosynthesis via the protein kinase C (PKC), high-osmolarity glycerol response (HOG...

journal_title：Antimicrobial agents and chemotherapy

authors： Fortwendel JR,Juvvadi PR,Perfect BZ,Rogg LE,Perfect JR,Steinbach WJ

更新日期：2010-04-01 00:00:00

abstract：:Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Cosgrove S,Harris A,Eliopoulos GM,Carmeli Y

更新日期：2001-09-01 00:00:00

abstract：:The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

更新日期：2011-09-01 00:00:00

abstract：:Many risk factors associated with aminoglycoside nephrotoxicity have been identified in humans and experimental animals. They include an initial high rate of creatinine clearance, high initial peak levels in serum, age, sex, duration of therapy, liver disease, and renal infection. The concomitant administration of ste...

journal_title：Antimicrobial agents and chemotherapy

authors： Beauchamp D,Pettigrew M

更新日期：1988-07-01 00:00:00

abstract：:Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was n...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Stevens DA

更新日期：1991-10-01 00:00:00

abstract：:PD 131628 is a new aminopyrrolidine-substituted fluorocyclopropyl naphthyridine quinolone which possesses high in vitro activity against a wide spectrum of bacterial species. The MICs for greater than or equal to 90% of strains were 0.125 to 0.25 microgram/ml for staphylococci, Streptococcus pyogenes, and S. pneumonia...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MA,Huband MD,Mailloux GB,Yoder SL,Roland GE,Domagala JM,Heifetz CL

更新日期：1991-01-01 00:00:00

abstract：:The effects of acid, oxgall, and H(2)O(2) on susceptibilities to antibiotics and nisin were examined for 13 strains of bifidobacteria. Susceptibilities to ampicillin, cloxacillin, penicillin, vancomycin, kanamycin, neomycin, paramomycin, streptomycin, chloramphenicol, erythromycin, tetracycline, and nisin A were assay...

journal_title：Antimicrobial agents and chemotherapy

authors： Kheadr E,Dabour N,Le Lay C,Lacroix C,Fliss I

更新日期：2007-01-01 00:00:00

abstract：:The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP; dehydropeptidase I)...

journal_title：Antimicrobial agents and chemotherapy

authors： Keynan S,Hooper NM,Felici A,Amicosante G,Turner AJ

更新日期：1995-07-01 00:00:00

abstract：:Although it is generally believed that bactericidal and bacteriostatic drugs should not be combined in vivo, in vitro experiments using the checkerboard dilution technique revealed no antagonism between penicillin/cephalothin and rolitetracycline but rather additive or synergistic activity of either drug combination i...

journal_title：Antimicrobial agents and chemotherapy

authors： Daschner FD

更新日期：1976-11-01 00:00:00

abstract：:Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic, and metabolic prope...

journal_title：Antimicrobial agents and chemotherapy

authors： Lake P,DeLeo J,Cerasoli F,Logdberg L,Weetall M,Handley D

更新日期：2004-08-01 00:00:00

abstract：:The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul M,Durand R,Fessi H,Rivollet D,Houin R,Astier A,Deniau M

更新日期：1997-08-01 00:00:00

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00