Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.

abstract：:Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more s...

journal_title：Antimicrobial agents and chemotherapy

authors： Nett JE,Crawford K,Marchillo K,Andes DR

更新日期：2010-08-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:Faldaprevir is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor with negligible urinary excretion. We assessed the pharmacokinetics and safety of a single oral dose of faldaprevir (480 mg) in 32 HCV-negative subjects with renal impairment or normal renal function. Compared with subjects with normal renal fun...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang F,Moschetti V,Lang B,Halabi A,Petersen-Sylla M,Yong CL,Elgadi M

更新日期：2015-01-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:Two hundred clinical isolates of Haemophilus influenzae were tested for tolerance (MBC/MIC greater than or equal to 32) to ampicillin and cefotaxime by broth dilution tests. Of 200 strains, 9 were tolerant to ampicillin, and 10 were tolerant to cefotaxime. Tolerant organisms were identified in both systemic and nonsys...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Lavoie GY

更新日期：1985-08-01 00:00:00

abstract：:Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Betuela I,Bassat Q,Kiniboro B,Robinson LJ,Rosanas-Urgell A,Stanisic D,Siba PM,Alonso PL,Mueller I

更新日期：2012-04-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00

abstract：:Pseudomonas aeruginosa colonizes the sputum of most adult cystic fibrosis patients, forming difficult-to-eradicate biofilms in which bacteria are protected in their self-produced extracellular polymeric substance (EPS) matrices. EPS provide biofilms with viscoelastic properties, causing time-dependent relaxation after...

journal_title：Antimicrobial agents and chemotherapy

authors： Rozenbaum RT,van der Mei HC,Woudstra W,de Jong ED,Busscher HJ,Sharma PK

更新日期：2019-03-27 00:00:00

abstract：:The in vitro activity of Bay v 3522, a new aminobenzothiazol cephem, was compared with those of other oral beta-lactams. Bay v 3522 displayed high activity against Staphylococcus spp. (MICs for 90% of strains tested [MIC90S], 0.5 micrograms/ml), Streptococcus pneumoniae (MIC90, 0.06 micrograms/ml), and Haemophilus inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Ashby JP,Thornber D

更新日期：1990-05-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime bu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lutsar I,Friedland IR,Jafri HS,Wubbel L,Ng W,Ghaffar F,McCracken GH Jr

更新日期：1999-07-01 00:00:00

abstract：:A new method for the analysis of serum chloramphenicol by reversed-phase, high-performance liquid chromatography (HPLC) is described. The method involves a preliminary extraction of 0.1 ml of serum with ethyl acetate containing an internal standard, chromatography with a reversed-phase C18 microparticulate column with...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Brodsky B,Lau A,Beam TR Jr

更新日期：1978-09-01 00:00:00

abstract：:The activity of DX-619 was evaluated against 376 anaerobic isolates using the reference CLSI agar dilution method. Overall, 90% of the strains were susceptible to DX-619 at < or =1 microg/ml. It was more active than the other four compounds tested except for meropenem, which showed virtually identical overall activity...

journal_title：Antimicrobial agents and chemotherapy

authors： Molitoris D,Väisänen ML,Bolaños M,Finegold SM

更新日期：2006-05-01 00:00:00

abstract：:Stenotrophomonas maltophilia is increasingly being isolated from the respiratory tract of individuals with cystic fibrosis, and, because of its multidrug-resistant nature, the selection of suitable treatment regimens can be problematical. Etest methodology was used to facilitate MIC and antimicrobial combination testi...

journal_title：Antimicrobial agents and chemotherapy

authors： Milne KE,Gould IM

更新日期：2012-08-01 00:00:00

abstract：:Bacterial susceptibility to a new organic acid related to nalidixic acid and oxolinic acid was tested. The in vitro susceptibility pattern of the new compound was found to be very similar to that of nalidixic acid. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gilis PM,Haemers A,Pattyn SR

更新日期：1978-03-01 00:00:00

abstract：:Nephrotoxicity is the main complication of gentamicin (GM) treatment. GM induces renal damage by overproduction of reactive oxygen species and inflammation in proximal tubular cells. Phenolic compounds from ginger, called gingerols, have been demonstrated to have antioxidant and anti-inflammatory effects. We investiga...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues FA,Prata MM,Oliveira IC,Alves NT,Freitas RE,Monteiro HS,Silva JA,Vieira PC,Viana DA,Libório AB,Havt A

更新日期：2014-01-01 00:00:00

abstract：:Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and a disk diffusion method. PCR was used to test drug-resistant genes, and the χ(2) test and definite probability methods were used to test for statistically significant differences among the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yin J,Yu S,Liu X,Li Y,Gao W,Ma X,Yang Y

更新日期：2011-01-01 00:00:00

abstract：:Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

更新日期：1987-09-01 00:00:00

abstract：:Clinical pharmacological studies of ticarcillin (alpha-carboxyl-3-thienylmethyl penicillin, BRL-2288) were conducted in patients with metastatic cancer and leukemia. After administration of 0.5 g intramuscularly, 1 g intramuscularly, and 1 g intravenously, the mean peak concentrations in serum were 18, 35, and 106 mug...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez V,Inagaki J,Bodey GP

更新日期：1973-07-01 00:00:00

abstract：:We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme i...

journal_title：Antimicrobial agents and chemotherapy

authors： Moriyama B,Elinoff J,Danner RL,Gea-Banacloche J,Pennick G,Rinaldi MG,Walsh TJ

更新日期：2009-04-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are converted to DXG by x...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen H,Boudinot FD,Chu CK,Mcclure HM,Schinazi RF

更新日期：1996-10-01 00:00:00

abstract：:Yersinia pestis is the etiologic agent of the plague. Reports of Y. pestis strains that are resistant to each of the currently approved first-line and prophylactic treatments point to the urgent need to develop novel antibiotics with activity against the pathogen. We previously reported that Y. pestis strain KIM6+, un...

journal_title：Antimicrobial agents and chemotherapy

authors： Steed DB,Liu J,Wasbrough E,Miller L,Halasohoris S,Miller J,Somerville B,Hershfield JR,Romesberg FE

更新日期：2015-07-01 00:00:00

abstract：:The pharmacokinetics and metabolism of 3'-azido-3'-deoxythymidine (AZT) were investigated in rhesus monkeys after subcutaneous administration of 33.3 mg of AZT per kg of body weight alone or in the presence of 100 mg of probenecid per kg. In addition to unchanged drug, two catabolites, 5'-O-glucuronide (GAZT) and 3'-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Cretton EM,Schinazi RF,McClure HM,Anderson DC,Sommadossi JP

更新日期：1991-05-01 00:00:00

abstract：:Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

更新日期：1984-09-01 00:00:00

abstract：:In Cambodia, multidrug-resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria, and new therapeutic options are needed. Pyronaridine-artesunate has not previously been evaluated in eastern Cambodia. We conducted a single-arm, open-label, prospective study between July and December 2017 at the...

journal_title：Antimicrobial agents and chemotherapy

authors： Leang R,Mairet-Khedim M,Chea H,Huy R,Khim N,Mey Bouth D,Dorina Bustos M,Ringwald P,Witkowski B

更新日期：2019-02-26 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00