Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.

Abstract:

:Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.

authors

Betuela I,Bassat Q,Kiniboro B,Robinson LJ,Rosanas-Urgell A,Stanisic D,Siba PM,Alonso PL,Mueller I

doi

10.1128/AAC.05566-11

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

2146-9

issue

4

eissn

0066-4804

issn

1098-6596

pii

AAC.05566-11

journal_volume

56

pub_type

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