High-performance liquid chromatographic assay of chloramphenicol in serum.

abstract：:The efficacy of a loading dose of 20 mg of chloroquine per kg of body weight per os given at intervals during the first day was evaluated in 27 patients in Madagascar with Plasmodium falciparum malaria. The conventional regimen of 25 mg/kg over 3 days (schedule 1) was thus compared with a regimen of 30 mg/kg over 2 da...

journal_title：Antimicrobial agents and chemotherapy

authors： Pussard E,Lepers JP,Clavier F,Raharimalala L,Le Bras J,Frisk-Holmberg M,Bergqvist Y,Verdier F

更新日期：1991-03-01 00:00:00

abstract：:Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumig...

journal_title：Antimicrobial agents and chemotherapy

authors： Denning DW,Venkateswarlu K,Oakley KL,Anderson MJ,Manning NJ,Stevens DA,Warnock DW,Kelly SL

更新日期：1997-06-01 00:00:00

abstract：:There has been a marked increase in the resistance of Neisseria gonorrhoeae isolated in Korea to penicillin, ampicillin, and tetracycline. In contrast, there has been no increased resistance to spectinomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson C,Rose DL,Tramont EC

更新日期：1976-04-01 00:00:00

abstract：:beta-L-2',3'-Dideoxy-5-fluorocytidine (beta-L-FddC), a novel cytidine analog with an unnatural beta-L sugar configuration, has been demonstrated by our group and others to exhibit highly selective in vitro activity against human immunodeficiency virus types 1 and 2 and hepatitis B virus. This encouraging in vitro anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Martin LT,Cretton-Scott E,Schinazi RF,Zhou XJ,McClure HM,Mathe C,Gosselin G,Imbach JL,Sommadossi JP

更新日期：1999-04-01 00:00:00

abstract：:Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Khlif M,Bogreau H,Michel-Nguyen A,Ayadi A,Ranque S

更新日期：2010-03-01 00:00:00

abstract：:ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae In this study, we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical is...

journal_title：Antimicrobial agents and chemotherapy

authors： Santos-Lopez A,Bernabe-Balas C,Ares-Arroyo M,Ortega-Huedo R,Hoefer A,San Millan A,Gonzalez-Zorn B

更新日期：2017-01-24 00:00:00

abstract：:The interrelationships between the pharmacokinetics of zidovudine alone and of zidovudine plus clarithromycin were evaluated with 18 volunteers with AIDS who had no infection with Mycobacterium avium complex or clinical evidence of gastroenteritis. Patients received 200 mg of zidovudine orally every 8 h on days 1 to 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Vance E,Watson-Bitar M,Gustavson L,Kazanjian P

更新日期：1995-06-01 00:00:00

abstract：:The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and increased survival of...

journal_title：Antimicrobial agents and chemotherapy

authors： Tong JX,Ang SEL,Tan EHN,Tan KSW

更新日期：2019-03-27 00:00:00

abstract：:We report 2 cases of recurrent Campylobacter coli enteritis caused by macrolide- and fluoroquinolone-resistant strains in 2 patients with hypogammaglobulinemia, successfully treated with a prolonged course of fosfomycin-tromethamine with no side effects. Fosfomycin-tromethamine may be a feasible alternative therapy fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aguilar-Company J,Los-Arcos I,Pigrau C,Rodríguez-Pardo D,Larrosa MN,Rodríguez-Garrido V,Sihuay-Diburga D,Almirante B

更新日期：2016-06-20 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:Use of combinations of antimicrobials that together achieve synergistic activities against targeted microorganisms is one potential strategy for overcoming bacterial resistance. As the incidence of infections caused by multidrug-resistant staphylococci and enterococci increases, the importance of devising additional s...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Cha R,Rybak MJ

更新日期：2002-08-01 00:00:00

abstract：:Cytomegalovirus can cause debilitating and life-threatening disease in newborns infected in utero and immunocompromised individuals, including transplant recipients. RG7667 is a unique combination of two monoclonal antibodies that binds glycoprotein complexes on the surface of cytomegalovirus and inhibits its entry in...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishida JH,Burgess T,Derby MA,Brown PA,Maia M,Deng R,Emu B,Feierbach B,Fouts AE,Liao XC,Tavel JA

更新日期：2015-08-01 00:00:00

abstract：:The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-amin...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Aires-de-Sousa M,Kudyba P,Kieffer N,Nordmann P

更新日期：2018-08-27 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucher LA,Chen YM,Walker JB

更新日期：1989-04-01 00:00:00

abstract：:In this study, two identical copies of a 23S-5S gene cluster, which are separately situated within the Helicobacter pylori UA802 chromosome, were cloned and sequenced. Comparison of the DNA sequence of the H. pylori 23S rRNA gene with known sequences of other bacterial 23S rRNA genes indicated that the H. pylori UA802...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Ge Z,Purych D,Lo T,Hiratsuka K

更新日期：1997-12-01 00:00:00

abstract：:When strains harboring R factor and showing ampicillin (APC) resistance were inoculated on plates containing various concentrations of APC, mutants carrying various levels of APC resistance occurred at high frequencies. Increases in the level of APC resistance were due to a quantitative increase in the formation of pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Odakura Y,Tanaka T,Hashimoto H,Mitsuhashi S

更新日期：1973-03-01 00:00:00

abstract：:Pulmonary infiltrates in neutropenic hosts with invasive aspergillosis are due to vascular invasion and hemorrhagic infarction. In order to measure the effect of antifungal compounds on this organism-mediated tissue injury, we monitored the course of pulmonary infiltrates by serial ultrafast computerized tomography (U...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Garrett K,Feurerstein E,Girton M,Allende M,Bacher J,Francesconi A,Schaufele R,Pizzo PA

更新日期：1995-05-01 00:00:00

abstract：:We evaluated MEDI8852, a human IgG1 monoclonal antibody that binds a highly conserved influenza A hemagglutinin stalk epitope, in outpatients with uncomplicated influenza A infection. A total of 126 subjects aged 18 to 65 years were enrolled during the 2015 to 2016 Northern and 2016 Southern Hemisphere seasons. Subjec...

journal_title：Antimicrobial agents and chemotherapy

authors： Ali SO,Takas T,Nyborg A,Shoemaker K,Kallewaard NL,Chiong R,Dubovsky F,Mallory RM

更新日期：2018-10-24 00:00:00

abstract：:N(2)-(3,4-Dichlorobenzyl)-7-(2-[1-morpholinyl]ethyl)guanine (MorE-DCBG, 362E) is a synthetic purine that selectively inhibits the replication-specific DNA polymerase of Clostridium difficile. MorE-DCBG and its analogs strongly inhibited the growth of a wide variety of C. difficile strains. When administered orally in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dvoskin S,Xu WC,Brown NC,Yanachkov IB,Yanachkova M,Wright GE

更新日期：2012-03-01 00:00:00

abstract：:The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound (MICs, < or = 0.125 microg/ml) against all Pasteurella species, Staphylococcus aureus, and streptococci; anaerobes were sus...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Hunt Gerardo S,Hudspeth M,Merriam CV

更新日期：1997-05-01 00:00:00

abstract：:The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model describing developme...

journal_title：Antimicrobial agents and chemotherapy

authors： Bijleveld YA,de Haan TR,van der Lee JH,Groenendaal F,Dijk PH,van Heijst A,de Jonge RCJ,Dijkman KP,van Straaten HLM,Rijken M,Zonnenberg IA,Cools F,Zecic A,Nuytemans DHGM,van Kaam AH,Mathôt RAA,PharmaCool Study Group.

更新日期：2018-03-27 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

更新日期：1999-09-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:Viridin B, a bacteriocin produced by Streptococcus mitis, copurified with the alpha-hemolysin after ammonium sulfate precipitation and gel filtration on Sephadex G-200. The bacteriocin and hemolysin were separated in some instances by ion-exchange chromatography on diethylaminoethyl-Sephadex A-50, but the two substanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Apelgren LD,Dajani AS

更新日期：1979-03-01 00:00:00

abstract：:The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergis...

journal_title：Antimicrobial agents and chemotherapy

authors： Michel J,Luboshitzky R,Sacks T

更新日期：1973-09-01 00:00:00

abstract：:Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated a...

journal_title：Antimicrobial agents and chemotherapy

authors： McKessar SJ,Berry AM,Bell JM,Turnidge JD,Paton JC

更新日期：2000-11-01 00:00:00

abstract：:Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

更新日期：2006-12-01 00:00:00

abstract：:Two 3-alkyl-substituted 2-hydroxy-1,4-naphthoquinones, NSC 113452 (NSC52) and NSC 113455 (NSC55), were evaluated for activity against Toxoplasma gondii in vitro and in murine models of acute toxoplasmosis. In vitro, both NSC52 and NSC55 significantly inhibited intracellular replication of T. gondii. In vivo, each comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Nasr M,Araujo FG

更新日期：1998-09-01 00:00:00