In vitro antibacterial activities of PD 131628, a new 1,8-naphthyridine anti-infective agent.

abstract：:We previously demonstrated the efficacy of ceftriaxone (CRO), at 50 mg/kg of body weight every 12 h, against a highly penicillin-resistant (MIC, 4 micrograms/ml) Streptococcus pneumoniae strain with low-level resistance to CRO (MIC, 0.5 microgram/ml) in a leukopenic-mouse pneumonia model (P. Moine, E. Vallée, E. Azoul...

journal_title：Antimicrobial agents and chemotherapy

authors： Sauve C,Azoulay-Dupuis E,Moine P,Darras-Joly C,Rieux V,Carbon C,Bédos JP

更新日期：1996-12-01 00:00:00

abstract：:A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. Species identification was confirmed by standard biochemical tests and analysis of 16S ribosomal DNA, gyrA, and gyrB sequences; all of the results were consistent with the S. aureus identification...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenover FC,Weigel LM,Appelbaum PC,McDougal LK,Chaitram J,McAllister S,Clark N,Killgore G,O'Hara CM,Jevitt L,Patel JB,Bozdogan B

更新日期：2004-01-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:The effect of moxalactam and cefuroxime on mitogen-stimulated human peripheral blood mononuclear leukocytes was studied. Mononuclear leukocytes, mitogen, and antibiotic were added to microtiter wells. Cells were cultured for 3 days, pulsed with tritiated thymidine, and then counted. Compared with control cell cultures...

journal_title：Antimicrobial agents and chemotherapy

authors： Manzella JP,Clark JK

更新日期：1983-03-01 00:00:00

abstract：:The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline solution for 1 month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodzic E,Feng S,Holden K,Freet KJ,Barthold SW

更新日期：2008-05-01 00:00:00

abstract：:The in vitro interactions between bismuth subcitrate and a variety of antimicrobial agents against 12 Campylobacter pyloridis (C. pylori) isolates were studied by the agar dilution checkerboard technique. The combination of bismuth subcitrate with the older quinolone, oxolinic acid, produced synergistic activity again...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Caekenberghe DL,Breyssens J

更新日期：1987-09-01 00:00:00

abstract：:Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences o...

journal_title：Antimicrobial agents and chemotherapy

authors： McClure JC,Crothers ML,Schaefer JJ,Stanley PD,Needham GR,Ewing SA,Stich RW

更新日期：2010-12-01 00:00:00

abstract：:Macrolide antibiotics like erythromycin can prevent the formation of the 50S ribosomal subunit in growing bacterial cells, in addition to their inhibitory effect on translation. The significance of this novel finding has been further investigated. The 50% inhibitory doses of erythromycin for the inhibition of translat...

journal_title：Antimicrobial agents and chemotherapy

authors： Champney WS,Burdine R

更新日期：1996-05-01 00:00:00

abstract：:Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult t...

journal_title：Antimicrobial agents and chemotherapy

authors： Fürnkranz U,Nagl M,Gottardi W,Köhsler M,Aspöck H,Walochnik J

更新日期：2008-02-01 00:00:00

abstract：:A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation a...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Mugnaioli C,Luzzaro F,Fiore M,Stefani S,Rossolini GM,Amicosante G

更新日期：2005-04-01 00:00:00

abstract：:Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were investigated for t...

journal_title：Antimicrobial agents and chemotherapy

authors： Auparakkitanon S,Noonpakdee W,Ralph RK,Denny WA,Wilairat P

更新日期：2003-12-01 00:00:00

abstract：:The pharmacokinetics of meropenem and its ring-opened metabolite (ICI 213,689) were investigated with eight young (20- to 34-year-old) and eight elderly (67- to 80-year-old) healthy male volunteers given single 30-min intravenous infusions of 500 mg of meropenem. All subjects had normal age-correlated glomerular funct...

journal_title：Antimicrobial agents and chemotherapy

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1992-07-01 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdon R,Polianski J,Gaudebout C,Marche C,Garry L,Pocidalo JJ

更新日期：1994-07-01 00:00:00

abstract：:Recent Food and Drug Administration (FDA) guidance endorses the use of an early clinical response endpoint as the primary outcome for community-acquired bacterial pneumonia (CABP) trials. While antibiotics will now be approved for CABP, in practice they will primarily be used to treat patients with community-acquired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zasowski E,Butterfield JM,McNutt LA,Cohen J,Cosler L,Pai MP,Gottwald J,Chen WZ,Lodise TP

更新日期：2014-07-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:We determined the pharmacodynamic parameter and the magnitude of that parameter that was predictive of the efficacy of fluconazole in the treatment of disseminated candidiasis. We used a neutropenic murine model of disseminated Candida albicans infection to characterize the time course of activity of fluconazole. Quan...

journal_title：Antimicrobial agents and chemotherapy

authors： Andes D,van Ogtrop M

更新日期：1999-09-01 00:00:00

abstract：:Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

更新日期：2012-06-01 00:00:00

abstract：:The pharmacologic parameters and toxicity of netilmicin (6 mg/kg/day) given once daily (qd) or thrice daily (tid) for the treatment of urinary tract infections were studied in a randomized prospective study of 60 cancer patients. The overall efficacy was 96%. Nephrotoxicity, assessed by the measure of urinary excretio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P,Meunier F,Ibrahim S,Kaufman L,Derde MP,Tulkens PM

更新日期：1991-04-01 00:00:00

abstract：:In Escherichia coli the frequency of spontaneous single-step mutation to high levels of resistance to the newer 4-quinolone agent norfloxacin was confirmed to be over 300-fold lower than that to the older agent nalidixic acid. Serial passage on incremental concentrations of drug was necessary to produce mutants highly...

journal_title：Antimicrobial agents and chemotherapy

authors： Hooper DC,Wolfson JS,Souza KS,Tung C,McHugh GL,Swartz MN

更新日期：1986-04-01 00:00:00

abstract：:Spiramycins are clinically important 16-member macrolide antibiotics produced by Streptomyces ambofaciens. Biosynthetic studies have established that the earliest lactonic intermediate in spiramycin biosynthesis, the macrolactone platenolide I, is synthesized by a type I modular polyketide synthase (PKS). Platenolide ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen HC,Darbon E,Thai R,Pernodet JL,Lautru S

更新日期：2013-08-01 00:00:00

abstract：:Thirteen derivatives of the Streptococcus pneumoniae TIGR4 strain in which putative drug efflux pumps were genetically inactivated were constructed and characterized. The results indicate that two linked genes encoding the ABC-type transporters SP2073 and SP2075 function together to confer intrinsic resistance to a se...

journal_title：Antimicrobial agents and chemotherapy

authors： Robertson GT,Doyle TB,Lynch AS

更新日期：2005-11-01 00:00:00

abstract：:Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Sáez-Llorens X,Macias M,Maiya P,Pineros J,Jafri HS,Chatterjee A,Ruiz G,Raghavan J,Bradshaw SK,Kartsonis NA,Sun P,Strohmaier KM,Fallon M,Bi S,Stone JA,Chow JW

更新日期：2009-03-01 00:00:00

abstract：:The emergence of human immunodeficiency virus type 1 (HIV-1) strains resistant to highly active antiretroviral therapy necessitates continued drug discovery for the treatment of HIV-1 infection. Most current drug discovery strategies focus upon a single aspect of HIV-1 replication. A virus-cell-based assay, which can ...

journal_title：Antimicrobial agents and chemotherapy

authors： Adelson ME,Pacchia AL,Kaul M,Rando RF,Ron Y,Peltz SW,Dougherty JP

更新日期：2003-02-01 00:00:00

abstract：:Invasive and allergic infections by Aspergillus flavus are more common in tropical and subtropical countries. The emergence of voriconazole (VRC) resistance in A. flavus impacts the management of aspergillosis, as azoles are used as the first-line and empirical therapy. We screened 120 molecularly confirmed A. flavus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sharma C,Kumar R,Kumar N,Masih A,Gupta D,Chowdhary A

更新日期：2018-02-23 00:00:00

abstract：:Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

journal_title：Antimicrobial agents and chemotherapy

authors： Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

更新日期：2017-03-24 00:00:00

abstract：:Mycobacterium tuberculosis strains with spontaneous mutations conferring resistance to rifampin (RIF) are exceedingly rare, and fixed drug combinations typically prevent augmentation of resistance to single drugs. Fourteen newly diagnosed tuberculosis patients were treated with RIF alone for 14 days, and bacterial loa...

journal_title：Antimicrobial agents and chemotherapy

authors： Kayigire XA,Friedrich SO,van der Merwe L,Diacon AH

更新日期：2017-03-24 00:00:00

abstract：:Novel penem molecules with heterocycle substitutions at the 6 position via a methylidene linkage were investigated for their activities and efficacy as beta-lactamase inhibitors. The concentrations of these molecules that resulted in 50% inhibition of enzyme activity were 0.4 to 3.1 nM for the TEM-1 enzyme, 7.8 to 72 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Murphy TM,Tardio L,Yang Y,Bradford PA,Venkatesan AM,Abe T,Isoda T,Mihira A,Ushirogochi H,Takasake T,Projan S,O'Connell J,Mansour TS

更新日期：2004-12-01 00:00:00

abstract：:Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellis D,Gosai J,Emrick C,Heintz R,Romans L,Gordon D,Lu SE,Austin F,Smith L

更新日期：2012-02-01 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00