Antimalarial 9-anilinoacridine compounds directed at hematin.

abstract：:To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had f...

journal_title：Antimicrobial agents and chemotherapy

authors： Larder BA,Bloor S,Kemp SD,Hertogs K,Desmet RL,Miller V,Sturmer M,Staszewski S,Ren J,Stammers DK,Stuart DI,Pauwels R

更新日期：1999-08-01 00:00:00

abstract：:Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantim...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Lovelace JK,Waits VB,Hanson WL,Klayman DL

更新日期：1990-05-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:Candida albicans and Staphylococcus aureus form vigorous polymicrobial biofilms in serum, which may serve as the source of coinfection in patients. More importantly, S. aureus is highly resistant to vancomycin during polymicrobial biofilm formation, with no decreases in bacterial viability observed with up to 1,600 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2010-09-01 00:00:00

abstract：:Sixty-three consecutive streptococcal blood isolates from neutropenic patients, represented mainly by viridans group streptococci, were evaluated in vitro for antibiotic susceptibility. Of these isolates, 79.3% were highly susceptible to penicillin (MIC, less than or equal to 0.12 microgram/ml). Overall, imipenem was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venditti M,Baiocchi P,Santini C,Brandimarte C,Serra P,Gentile G,Girmenia C,Martino P

更新日期：1989-04-01 00:00:00

abstract：:Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Trépanier S,Prince A,Huletsky A

更新日期：1997-11-01 00:00:00

abstract：:Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou X,Xiao M,Wang H,Yu SY,Zhang G,Zhao Y,Xu YC

更新日期：2018-05-25 00:00:00

abstract：:In vitro susceptibility testing of 28 strains of Eikenella corrodens by the agar dilution technique showed that all strains were uniformly susceptible to penicillin, ticarcillin, cefoxitin, cefotaxime, N-formimidoyl thienamycin, and moxalactam and resistant to clindamycin and cefadroxil. Cefoperazone, piperacillin, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Gombert ME,Agyare EO

更新日期：1980-11-01 00:00:00

abstract：:Antibiotic treatment of lung infections may lead to the emergence of resistance in the gut flora. Appropriate dosing regimens could mitigate this adverse effect. In gnotobiotic rats harboring intestinal Escherichia coli and Enterococcus faecium populations, a lung infection by Klebsiella pneumoniae was instigated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2010-07-01 00:00:00

abstract：:We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics w...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyamoto Y,Takizawa K,Matsushima A,Asai Y,Nakatsuka S

更新日期：1978-03-01 00:00:00

abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

journal_title：Antimicrobial agents and chemotherapy

authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

更新日期：2010-03-01 00:00:00

abstract：:Strains of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 (DT104) and S. enterica serovar Agona (Agona) have been found to harbor Salmonella genomic island 1 (SGI1), a 43-kb genomic region that contains many of the drug resistance genes. Such strains are resistant to ampicillin (pse-1), chlorampheni...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd D,Cloeckaert A,Chaslus-Dancla E,Mulvey MR

更新日期：2002-06-01 00:00:00

abstract：:The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Binder U,Maurer E,Lackner M,Lass-Flörl C

更新日期：2015-03-01 00:00:00

abstract：:The most appropriate vancomycin dosing strategy in pediatric patients weighing ≥70 kg (weight based versus non-weight based) to achieve an area under the concentration-time curve (AUC) of ≥400 mg·liter/h and a trough concentration of <20 mg/liter is not known. Population pharmacokinetic analysis determined that dosing...

journal_title：Antimicrobial agents and chemotherapy

authors： Moffett BS,Ivaturi V,Morris J,Akcan Arikan A,Dutta A

更新日期：2019-03-27 00:00:00

abstract：:The lipopeptidic antibiotic daptomycin is reported to reduce experimental tobramycin nephrotoxicity (D. Beauchamp, M. Pellerin, P. Gourde, M. Pettigrew and M. G. Bergeron, Antimicrob. Agents Chemother. 34:139-147, 1990; C. A. Wood, H. C. Finkbeiner, S. J. Kohlhepp, P. W. Kohnen, and D. C. Gilbert, Antimicrob. Agents C...

journal_title：Antimicrobial agents and chemotherapy

authors： Couture M,Simard M,Gourde P,Lessard C,Gurnani K,Lin L,Carrier D,Bergeron MG,Beauchamp D

更新日期：1994-04-01 00:00:00

abstract：:The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

journal_title：Antimicrobial agents and chemotherapy

authors： Fick RB Jr,Alexander MR,Prince RA,Kasik JE

更新日期：1987-05-01 00:00:00

abstract：:The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson BC,Métifiot M,Pommier Y,Hughes SH

更新日期：2012-01-01 00:00:00

abstract：:Eravacycline is a fluorocycline antibiotic in phase 3 clinical development for complicated intra-abdominal and urinary tract infections. To support its clinical development, a study was conducted to evaluate the effects of various susceptibility test parameters on the MIC values for aerobic bacteria. The results showe...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Pillar CM,Sahm DF,Sutcliffe JA

更新日期：2015-04-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. All strains producing a probe-type enzyme gave a positive hybridization reaction. C...

journal_title：Antimicrobial agents and chemotherapy

authors： Huovinen S,Huovinén P,Jacoby GA

更新日期：1988-02-01 00:00:00

abstract：:Ten (0.05%) of 18,628 strains of Streptococcus pyogenes isolated from clinical specimens in the 3 years 1968 to 1970 were resistant to lincomycin and erythromycin. All 10 strains were highly resistant to lincomycin, having minimal inhibitory concentration (MIC) values of 200 mug/ml. There were two degrees of resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon JM,Lipinski AE

更新日期：1972-04-01 00:00:00

abstract：:The mechanism of colistin resistance (Col(r)) in Acinetobacter baumannii was studied by selecting in vitro Col(r) derivatives of the multidrug-resistant A. baumannii isolate AB0057 and the drug-susceptible strain ATCC 17978, using escalating concentrations of colistin in liquid culture. DNA sequencing identified mutat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams MD,Nickel GC,Bajaksouzian S,Lavender H,Murthy AR,Jacobs MR,Bonomo RA

更新日期：2009-09-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:Tuberculosis (TB) treatment is long and requires multiple drugs, likely due to various phenotypes of TB bacilli with variable drug susceptibilities. Drugs with broad activity are urgently needed. This study aimed to evaluate delamanid's activity against growing or dormant bacilli in vitro as well as in vivo Cultures o...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen X,Hashizume H,Tomishige T,Nakamura I,Matsuba M,Fujiwara M,Kitamoto R,Hanaki E,Ohba Y,Matsumoto M

更新日期：2017-05-24 00:00:00

abstract：:Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with d...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Shang W,Bush K,Flamm RK

更新日期：2008-04-01 00:00:00

abstract：:The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

更新日期：2014-01-01 00:00:00

abstract：:The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin doses of 0 to 100 mg/kg of body weight and sacrificed 7 days later. The maximal decline in kidney fungal burden was 5.8 l...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T,Drusano GL,Liu W,Kulawy RW,Fregeau C,Hsu V,Louie A

更新日期：2007-03-01 00:00:00