Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity.

abstract：:Antimicrobial cationic peptides are ubiquitous in nature and are thought to be a component of the first line of defense against infectious agents. It is widely believed that the killing mechanism of these peptides on bacteria involves an interaction with the cytoplasmic membrane. Cationic peptides from different struc...

journal_title：Antimicrobial agents and chemotherapy

authors： Friedrich CL,Moyles D,Beveridge TJ,Hancock RE

更新日期：2000-08-01 00:00:00

abstract：:The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readi...

journal_title：Antimicrobial agents and chemotherapy

authors： Raponi G,Keller N,Overbeek BP,Rozenberg-Arska M,van Kessel KP,Verhoef J

更新日期：1990-02-01 00:00:00

abstract：:Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

journal_title：Antimicrobial agents and chemotherapy

authors： Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

更新日期：2018-07-27 00:00:00

abstract：:The spectrum of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase (RT) mutations selected by antiretroviral (ARV) drugs requires ongoing reassessment as ARV treatment patterns evolve and increasing numbers of protease and RT sequences of different viral subtypes are published. Accordingly,...

journal_title：Antimicrobial agents and chemotherapy

authors： Shahriar R,Rhee SY,Liu TF,Fessel WJ,Scarsella A,Towner W,Holmes SP,Zolopa AR,Shafer RW

更新日期：2009-11-01 00:00:00

abstract：:A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral plasma half-life of great...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CM,He Y,Lu L,Lim HB,Tripathi RL,Middleton T,Hernandez LE,Beno DW,Long MA,Kati WM,Bosse TD,Larson DP,Wagner R,Lanford RE,Kohlbrenner WE,Kempf DJ,Pilot-Matias TJ,Molla A

更新日期：2007-12-01 00:00:00

abstract：:This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance in constitutively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Bacciaglia A,Vecchi M,Vitali LA,Varaldo PE,Giovanetti E

更新日期：2007-04-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Candida glabrata, the second most common cause of Candida infections, is associated with high rates of mortality and often exhibits resistance to the azole class of antifungal agents. Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding ...

journal_title：Antimicrobial agents and chemotherapy

authors： Whaley SG,Caudle KE,Vermitsky JP,Chadwick SG,Toner G,Barker KS,Gygax SE,Rogers PD

更新日期：2014-08-01 00:00:00

abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Schwartz JA,Stevens DA

更新日期：2012-08-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:The class 1 integron In28, found in the multidrug resistance transposon Tn1403, was found to be located in the res site of the backbone transposon and is flanked by a 5-bp direct duplication, indicating that it reached this position by transposition. In28 has a backbone structure related to that of In4, but has lost i...

journal_title：Antimicrobial agents and chemotherapy

authors： Partridge SR,Recchia GD,Stokes HW,Hall RM

更新日期：2001-11-01 00:00:00

abstract：:The experimental model of infected fibrin clots in rabbits was used to study the penetration and in vivo activity of cefixime against Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. The respective MICs of cefixime against these strains were 0.25, 2, and 8 micrograms/ml. The clots were infected with...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Turcotte A

更新日期：1986-12-01 00:00:00

abstract：:Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+...

journal_title：Antimicrobial agents and chemotherapy

authors： Bermudez LE,Inderlied CB,Kolonoski P,Chee CB,Aralar P,Petrofsky M,Parman T,Green CE,Lewin AH,Ellis WY,Young LS

更新日期：2012-08-01 00:00:00

abstract：:Prophylactic administration of a nontoxic dose of 9-[[2-benzyloxyl-1-(benzyloxymethyl)ethoxy]methyl]-6-chlo roguanine (BIOLF-70) to mice reduced the number of myocarditic lesions induced by coxsackievirus B3 (CVB3). BIOLF-70 exhibited minimal antiviral activity against CVB3 in HeLa cells and murine neonatal skin fibro...

journal_title：Antimicrobial agents and chemotherapy

authors： Gauntt CJ,Arizpe HM,Kung JT,Ogilvie KK,Cheriyan UO

更新日期：1985-02-01 00:00:00

abstract：:This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

更新日期：2010-09-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:Steady-state concentrations of telavancin, a novel, bactericidal lipoglycopeptide, were determined in the plasma, pulmonary epithelial lining fluid (ELF), and alveolar macrophages (AMs) of 20 healthy subjects. Telavancin at 10 mg of drug/kg of body weight/day was administered as a 1-h intravenous infusion on three suc...

journal_title：Antimicrobial agents and chemotherapy

authors： Gotfried MH,Shaw JP,Benton BM,Krause KM,Goldberg MR,Kitt MM,Barriere SL

更新日期：2008-01-01 00:00:00

abstract：:Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

journal_title：Antimicrobial agents and chemotherapy

authors： Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

更新日期：1985-02-01 00:00:00

abstract：:Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transami...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormack WM,George H,Donner A,Kodgis LF,Alpert S,Lowe EW,Kass EH

更新日期：1977-11-01 00:00:00

abstract：:In vitro selection of mutants with decreased susceptibility to ertapenem was performed using Escherichia coli and Klebsiella pneumoniae clinical strains producing either the bla(CTX-M-2), bla(CTX-M-3), bla(CTX-M-9), or bla(CTX-M-15) gene. Frequencies of mutants with decreased susceptibilities to ertapenem were similar...

journal_title：Antimicrobial agents and chemotherapy

authors： Girlich D,Poirel L,Nordmann P

更新日期：2009-02-01 00:00:00

abstract：:The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Fothergill AW,Arzeni D,Greganti G,Giannini D,Rinaldi MG,Scalise G

更新日期：2005-06-01 00:00:00

abstract：:In patients with polytrauma or major surgery, severe bacterial infections leading to septic shock and multiorgan failure are still a major cause of death. Prevention of septic shock in patients at risk would be an alternative to treatment of patients with overt septic shock. We therefore conducted a trial with the mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Passlick B,Labeta MO,Izbicki JR,Ostertag P,Löffler T,Siebeck M,Pichlmeier U,Schweiberer L,Ziegler-Heitbrock HW

更新日期：1995-11-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were f...

journal_title：Antimicrobial agents and chemotherapy

authors： Girard AE,English AR,Evangelisti DG,Lynch JE,Solomons IA

更新日期：1976-07-01 00:00:00

abstract：:We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. The degree of potentiation as estimated by standard isobolar...

journal_title：Antimicrobial agents and chemotherapy

authors： Winter RW,Cornell KA,Johnson LL,Ignatushchenko M,Hinrichs DJ,Riscoe MK

更新日期：1996-06-01 00:00:00

abstract：:Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD...

journal_title：Antimicrobial agents and chemotherapy

authors： Locher HH,Seiler P,Chen X,Schroeder S,Pfaff P,Enderlin M,Klenk A,Fournier E,Hubschwerlen C,Ritz D,Kelly CP,Keck W

更新日期：2014-01-01 00:00:00

abstract：:Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline and azithromycin, but it is unclear whether their efficacies are equivalent. We conducted a multicenter, open, randomized controlled trial with adult patients presenting with acute fe...

journal_title：Antimicrobial agents and chemotherapy

authors： Phimda K,Hoontrakul S,Suttinont C,Chareonwat S,Losuwanaluk K,Chueasuwanchai S,Chierakul W,Suwancharoen D,Silpasakorn S,Saisongkorh W,Peacock SJ,Day NP,Suputtamongkol Y

更新日期：2007-09-01 00:00:00

abstract：:The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Novotna GB,Kwun MJ,Hong HJ

更新日期：2015-12-28 00:00:00

abstract：:Cefodizime, an iminomethoxy aminothiazolyl cephalosporin similar to moxalactam and ceftazidime, was less active (minimal inhibitory concentration, 1.6 to 12 micrograms) than cefazolin or cefotaxime against Staphylococcus aureus and Staphylococcus epidermidis. It inhibited Haemophilus and Neisseria spp. at less than 0....

journal_title：Antimicrobial agents and chemotherapy

authors： Scully BE,Jules K,Neu HC

更新日期：1983-06-01 00:00:00

abstract：:Cefamandole pharmacokinetics were investigated in 24 adult males with stable renal function and creatinine clearances of 0 to 139 ml/min. After intramuscular injection of 1.0 g of cefamandole, peak plasma concentrations were achieved between 1 and 2 h. Maximum plasma concentration and drug half-life increased as creat...

journal_title：Antimicrobial agents and chemotherapy

authors： Czerwinski AW,Pederson JA

更新日期：1979-02-01 00:00:00