Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli.

abstract：:Posaconazole (POS) is a new antifungal agent for prevention and therapy of mycoses in immunocompromised patients. Variable POS pharmacokinetics after oral dosing may influence efficacy: a trough threshold of 0.5 μg/ml has been recently proposed. Measurement of POS plasma concentrations by complex chromatographic techn...

journal_title：Antimicrobial agents and chemotherapy

authors： Rochat B,Pascual A,Pesse B,Lamoth F,Sanglard D,Decosterd LA,Bille J,Marchetti O

更新日期：2010-12-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:Among hospitalized adults who received vancomycin for their skin and skin structure infection (SSSI), patients who experienced acute kidney injury (AKI) had considerably higher 30-day readmission rates. Nearly half of the observed 30-day readmissions were due to non-SSSI-related reasons, which is consistent with the p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel N,Stornelli N,Sangiovanni RJ,Huang DB,Lodise TP

更新日期：2020-09-21 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously...

journal_title：Antimicrobial agents and chemotherapy

authors： Joseph P,Abdo MR,Boigegrain RA,Montero JL,Winum JY,Köhler S

更新日期：2007-10-01 00:00:00

abstract：:When growing bacteria are exposed to bactericidal concentrations of antibiotics, the sensitivity of the bacteria to the antibiotic commonly decreases with time, and substantial fractions of the bacteria survive. Using Escherichia coli CAB1 and antibiotics of five different classes (ampicillin, ciprofloxacin, rifampin,...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiuff C,Zappala RM,Regoes RR,Garner KN,Baquero F,Levin BR

更新日期：2005-04-01 00:00:00

abstract：:Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to...

journal_title：Antimicrobial agents and chemotherapy

authors： Moyo S,Haldorsen B,Aboud S,Blomberg B,Maselle SY,Sundsfjord A,Langeland N,Samuelsen Ø

更新日期：2015-01-01 00:00:00

abstract：:In addition to cholesterol-lowering capabilities, statins possess anti-inflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized pati...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey AR,Timbrook TT,Noh E,Sakoulas G,Opal SM,Nizet V,LaPlante KL

更新日期：2017-02-23 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00

abstract：:Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC D...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdugo D,Fallows D,Ahuja S,Schluger N,Kreiswirth B,Mathema B

更新日期：2015-10-01 00:00:00

abstract：:Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachmann SP,VandeWalle K,Ramage G,Patterson TF,Wickes BL,Graybill JR,López-Ribot JL

更新日期：2002-11-01 00:00:00

abstract：:We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibac...

journal_title：Antimicrobial agents and chemotherapy

authors： Munoz-Price LS,Reeme AE,Buchan BW,Mettus RT,Mustapha MM,Van Tyne D,Shields RK,Doi Y

更新日期：2019-09-23 00:00:00

abstract：:Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Caughey WS,Priola SA,Kocisko DA,Raymond LD,Ward A,Caughey B

更新日期：2007-11-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoeksema M,Brul S,Ter Kuile BH

更新日期：2018-05-25 00:00:00

abstract：:Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by se...

journal_title：Antimicrobial agents and chemotherapy

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2009-12-01 00:00:00

abstract：:Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Montealegre MC,Roh JH,Rae M,Davlieva MG,Singh KV,Shamoo Y,Murray BE

更新日期：2016-12-27 00:00:00

abstract：:MICs, time-kills, and postantibiotic effects (PAEs) of ABT-773 (a new ketolide) and 10 other agents were determined against 226 pneumococci. Against 78 ermB- and 44 mefE-containing strains, ABT-773 MICs at which 50% of the isolates tested were inhibited (MIC(50)s) and MIC(90)s were 0.016 to 0.03 and 0.125 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Ednie LM,Hoellman DM,Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：2000-07-01 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus, and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of effort, we have...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang FK,Huang SM,Liao CL,Lee AR,Lien SP,Chiu YL,Chang TH,Tsai PL,Lin RJ,Shih CC,Tsai YJ,Lin GJ,Yen LC

更新日期：2019-12-20 00:00:00

abstract：:Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline and azithromycin, but it is unclear whether their efficacies are equivalent. We conducted a multicenter, open, randomized controlled trial with adult patients presenting with acute fe...

journal_title：Antimicrobial agents and chemotherapy

authors： Phimda K,Hoontrakul S,Suttinont C,Chareonwat S,Losuwanaluk K,Chueasuwanchai S,Chierakul W,Suwancharoen D,Silpasakorn S,Saisongkorh W,Peacock SJ,Day NP,Suputtamongkol Y

更新日期：2007-09-01 00:00:00

abstract：:Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Zebedee SL,Koduri RK,Mukherjee J,Mukherjee S,Lee S,Sauer DF,Scharff MD,Casadevall A

更新日期：1994-07-01 00:00:00

abstract：:Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide. This microbe's propensity to form biofilms allows it to persist and to survive on clinical abiotic surfaces for long periods. In fact, A. baumannii biofilm formation and its multidrug-resistant nature severely compromise ...

journal_title：Antimicrobial agents and chemotherapy

authors： Krishnamoorthy S,Shah BP,Lee HH,Martinez LR

更新日期：2015-10-12 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:Iron-sulfur flavoproteins (Isf) are flavin mononucleotide (FMN)- and FeS cluster-containing proteins commonly encountered in anaerobic prokaryotes. However, with the exception of Isf from Methanosarcina thermophila, which participates in oxidative stress management by removing oxygen and hydrogen peroxide, none of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Smutná T,Pilarová K,Tarábek J,Tachezy J,Hrdý I

更新日期：2014-06-01 00:00:00

abstract：:We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Asperg...

journal_title：Antimicrobial agents and chemotherapy

authors： Arikan S,Lozano-Chiu M,Paetznick V,Rex JH

更新日期：2001-01-01 00:00:00

abstract：:Because of the rising incidence of failures in the treatment of oropharyngeal candidosis in the case of severely immunosuppressed patients (mostly human immunodeficiency virus [HIV]-infected patients), there is need for the development of new, more effective agents and/or compounds that support the activity of the com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuipers ME,de Vries HG,Eikelboom MC,Meijer DK,Swart PJ

更新日期：1999-11-01 00:00:00

abstract：:Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of conditions applying to in...

journal_title：Antimicrobial agents and chemotherapy

authors： Parapini S,Olliaro P,Navaratnam V,Taramelli D,Basilico N

更新日期：2015-07-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00