Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei.

abstract：:A new reverse transcriptase (RT) inhibitor was extracted and purified from the red alga Schizymenia pacifica. The chromatographic behavior and chemical properties of this sea algal extract (SAE) suggest that it is a sulfated polysaccharide having a molecular weight of approximately 2,000,000. SAE is composed of galact...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakashima H,Kido Y,Kobayashi N,Motoki Y,Neushul M,Yamamoto N

更新日期：1987-10-01 00:00:00

abstract：:There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim H,Kim ES,Lee SC,Yang E,Kim HS,Sung H,Kim MN,Jung J,Kim MJ,Kim SH,Lee SO,Choi SH,Woo JH,Kim YS,Chong YP

更新日期：2020-09-21 00:00:00

abstract：:The gene ere(A) of the plasmid pIP1100 is larger than originally reported and is organized as an integron gene cassette. The ere(A) gene cassette carries its own promoter and is propagated by a class 2 integron with an insertion sequence element, IS1, inserted upstream of the intI2 gene. The mobility of the ere(A) cas...

journal_title：Antimicrobial agents and chemotherapy

authors： Biskri L,Mazel D

更新日期：2003-10-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:The "HACEK" organisms are a group of fastidious Gram-negative bacteria that cause a variety of infections, including infective endocarditis. Antimicrobial susceptibility testing is not universally available, and therapy for these infections is often empirical. We report the antimicrobial susceptibilities of 70 clinica...

journal_title：Antimicrobial agents and chemotherapy

authors： Coburn B,Toye B,Rawte P,Jamieson FB,Farrell DJ,Patel SN

更新日期：2013-04-01 00:00:00

abstract：:Hand-foot-and-mouth disease (HFMD), caused by enterovirus, is a threat to public health worldwide. To date, enterovirus 71 (EV71) has been one of the major causative agents of HFMD in the Pacific-Asia region, and outbreaks with EV71 cause millions of infections. However, no drug is currently available for clinical the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang Y,Cao L,Zhai Y,Yin Z,Sun Y,Shang L

更新日期：2017-06-27 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are resistant to most antibiotics, making CRE infections extremely difficult to treat with available agents. Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) are predominant carbapenemases in CRE in the United States. Nacubactam is a bridged diazabicyclooctane (DBO) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes MD,Taracila MA,Good CE,Bajaksouzian S,Rojas LJ,van Duin D,Kreiswirth BN,Jacobs MR,Haldimann A,Papp-Wallace KM,Bonomo RA

更新日期：2019-07-25 00:00:00

abstract：:The molecular mechanisms of resistance to fluoroquinolones, tetracyclines, an aminocyclitol, macrolides, a lincosamide, a phenicol, and pleuromutilins were investigated in Mycoplasma bovis For the identification of mutations responsible for the high MICs of certain antibiotics, whole-genome sequencing of 35 M. bovis f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sulyok KM,Kreizinger Z,Wehmann E,Lysnyansky I,Bányai K,Marton S,Jerzsele Á,Rónai Z,Turcsányi I,Makrai L,Jánosi S,Nagy SÁ,Gyuranecz M

更新日期：2017-01-24 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00

abstract：:The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul M,Durand R,Fessi H,Rivollet D,Houin R,Astier A,Deniau M

更新日期：1997-08-01 00:00:00

abstract：:Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD...

journal_title：Antimicrobial agents and chemotherapy

authors： Locher HH,Seiler P,Chen X,Schroeder S,Pfaff P,Enderlin M,Klenk A,Fournier E,Hubschwerlen C,Ritz D,Kelly CP,Keck W

更新日期：2014-01-01 00:00:00

abstract：:The in vitro activities of HMR 3647 (telithromycin) and HMR 3004, two novel semisynthetic ketolides, were investigated and compared with that of the reference macrolide drug, clarithromycin, against 34 strains of slowly growing mycobacteria at pHs 6.8 and 7.4, as determined radiometrically. The MICs at pH 7.4 were abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Berchel M,Bryskier A

更新日期：2000-10-01 00:00:00

abstract：:Since human cytomegalovirus (HCMV) does not infect or replicate in nonhuman cells and tissues, there are few animal models currently available for evaluation of antiviral therapies for these infections. In the present studies, we utilized two different models in which severe combined immunodeficient (SCID) mice were i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline CB,Rybak RJ,Drach JC,Townsend LB,Biron KK,Bidanset DJ

更新日期：2004-05-01 00:00:00

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with r...

journal_title：Antimicrobial agents and chemotherapy

authors： Furi L,Ciusa ML,Knight D,Di Lorenzo V,Tocci N,Cirasola D,Aragones L,Coelho JR,Freitas AT,Marchi E,Moce L,Visa P,Northwood JB,Viti C,Borghi E,Orefici G,BIOHYPO Consortium.,Morrissey I,Oggioni MR

更新日期：2013-08-01 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:(1,3)Beta-D-glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-beta-D-glucan 3-beta-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-beta-linkages) to form the major carbohydrate component of the fungal cell wall. We have optimized in vitro assay conditions for (1,3)bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Maligie MA,Selitrennikoff CP

更新日期：2005-07-01 00:00:00

abstract：:Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

更新日期：1999-07-01 00:00:00

abstract：:High-level resistance to quinolones has previously been shown to occur in Campylobacter spp. both in vitro and in patients treated with quinolones. We have selected isolates that are resistant to quinolones by plating cells from a susceptible C. jejuni strain, UA535, on medium containing nalidixic acid at 32 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Martin BA

更新日期：1991-05-01 00:00:00

abstract：:Moxifloxacin (MXF) is a fluoroquinolone antibiotic that is effective against respiratory infections. However, the mechanisms of MXF lung diffusion are unknown. Active transport in other tissues has been suggested for several members of the fluoroquinolone family. In this study, transport of MXF was systematically inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Brillault J,De Castro WV,Harnois T,Kitzis A,Olivier JC,Couet W

更新日期：2009-04-01 00:00:00

abstract：:WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The M...

journal_title：Antimicrobial agents and chemotherapy

authors： Shah LM,DeStefano MS,Cynamon MH

更新日期：1996-11-01 00:00:00

abstract：:Adenosine monophosphate pretreatment of mice with latent herpes simplex virus type 1 infections significantly reduced the rate of reactivation of latent virus. Adenosine monophosphate pretreatment did not, however, eradicate latent virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blue WT,Winland RD,Stobbs DG,Kirksey DF,Savage RE

更新日期：1981-10-01 00:00:00

abstract：:Cell-free amino acid incorporation using ribosomes from strains of either Clostridium perfringens or Bacteroides fragilis was shown to be susceptible to inhibition by streptomycin and gentamicin. Ribosomes bound dihydrostreptomycin as effectively as ribosomes from Escherichia coli. No inactivation of streptomycin or g...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan LE,Kowand SK,Van Den Elzen HM

更新日期：1979-01-01 00:00:00

abstract：:Carbapenemases are among the newest resistance mechanisms to emerge in some gram-negative bacteria. We describe bacteremia in a critically ill liver transplant recipient infected with KPC-2-producing Enterobacter cloacae and Pseudomonas putida. Although this enzyme has been previously described in Enterobacter spp., t...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett JW,Herrera ML,Lewis JS 2nd,Wickes BW,Jorgensen JH

更新日期：2009-01-01 00:00:00

abstract：:The Capnocytophaga sputigena isolate NOR, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. In a cloning experiment, a new gene, bla(CSP-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (ESBL) that shares only 52% and 49% identities with the CME-...

journal_title：Antimicrobial agents and chemotherapy

authors： Guillon H,Eb F,Mammeri H

更新日期：2010-05-01 00:00:00

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DB,Ott JL

更新日期：1986-05-01 00:00:00

abstract：:In order to establish a screening system for xenosiderophores which can be utilized by mycobacteria, we generated a set of mutants of Mycobacterium smegmatis that are blocked in different steps of the well-known iron acquisition system. One mutant with a block in mycobactin biosynthesis was generated from strain mc(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Schumann G,Möllmann U

更新日期：2001-05-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00